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公开(公告)号：US5827817A
公开(公告)日：1998-10-27
申请号：US477254
申请日：1995-06-07
申请人： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw , Ray Camphausen
发明人： Glenn R. Larsen , Dianne S. Sako , Xiao-Jia Chang , Geertruida M. Veldman , Dale Cumming , Ravindra Kumar , Gray Shaw , Ray Camphausen
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K19/00 , C12N9/10 , C12N9/64 , C12N15/12 , A61K38/17 , C07K7/08 , C07K14/435
CPC分类号： C12N9/6454 , C07K14/4703 , C07K14/705 , C07K16/2851 , C07K16/2854 , C07K19/00 , C12N9/10 , C12N9/1051 , A61K38/00 , A61K39/00 , C07K2317/34 , C07K2319/00 , C07K2319/24 , Y10S514/844 , Y10S514/937 , Y10S514/944
摘要： A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
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公开(公告)号：US09469676B2
公开(公告)日：2016-10-18
申请号：US14111327
申请日：2012-04-13
CPC分类号： C07K14/78 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/244 , C07K16/2863 , C07K16/40 , C07K16/46 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , G01N33/573 , G01N2333/948
摘要： The application provides Fc fusion proteins having novel arrangements. In one embodiment, the application provides Fc fusion proteins comprising a 10Fn3 domain. In another embodiment, the application provides Fc fusion proteins comprising linkers derived from the naturally occurring C-terminal tail regions of membrane bound or secretory immunoglobulins.
摘要翻译： 该应用提供具有新颖设计的Fc融合蛋白。 在一个实施方案中，本申请提供包含10Fn3结构域的Fc融合蛋白。 在另一个实施方案中，本申请提供Fc融合蛋白，其包含衍生自膜结合或分泌免疫球蛋白的天然存在的C末端尾区的接头。
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13.发明授权Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including IGF-IR 有权基于用于酪氨酸激酶受体的工程化蛋白质的靶向治疗剂，包括IGF-1R公开(公告)号：US08470332B2
公开(公告)日：2013-06-25
申请号：US12312725
申请日：2007-11-21
IPC分类号： A61K38/17 , A61K38/39 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/18 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , C07K2319/74 , C12N15/1062 , C40B30/04 , C40B40/08 , C40B40/10
摘要： The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明提供了与胰岛素样生长因子-I受体（IGF-1R）以及其它重要蛋白质结合的创新蛋白质。 本发明还提供药物制剂中的创新蛋白质和这种蛋白质的衍生物及其在诊断，研究和治疗应用中的用途。 本发明还提供包含这些蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US08524244B2
公开(公告)日：2013-09-03
申请号：US12867406
申请日：2009-02-10
申请人： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
发明人： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
IPC分类号： A61K38/17 , A61K38/39 , A61K47/48 , C07K14/71 , C07K14/435
CPC分类号： C07K14/78 , A61K38/00 , C07K14/765 , C07K14/79 , C07K16/2863 , C07K19/00 , C07K2317/31 , C07K2318/20 , C07K2319/30
摘要： The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明涉及结合表皮生长因子受体（EGFR）的单结构域蛋白。 本发明还涉及用于诊断，研究和治疗应用的单结构域蛋白。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US20110053842A1
公开(公告)日：2011-03-03
申请号：US12867406
申请日：2009-02-10
申请人： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
发明人： Ray Camphausen , Brent Morse , Stuart Emanuel , David Fabrizio
CPC分类号： C07K14/78 , A61K38/00 , C07K14/765 , C07K14/79 , C07K16/2863 , C07K19/00 , C07K2317/31 , C07K2318/20 , C07K2319/30
摘要： The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明涉及结合表皮生长因子受体（EGFR）的单结构域蛋白。 本发明还涉及用于诊断，研究和治疗应用的单结构域蛋白。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US20140113370A1
公开(公告)日：2014-04-24
申请号：US14111327
申请日：2012-04-13
CPC分类号： C07K14/78 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/244 , C07K16/2863 , C07K16/40 , C07K16/46 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , G01N33/573 , G01N2333/948
摘要： The application provides Fc fusion proteins having novel arrangements. In one embodiment, the application provides Fc fusion proteins comprising a 10Fn3 domain. In another embodiment, the application provides Fc fusion proteins comprising linkers derived from the naturally occurring C-terminal tail regions of membrane bound or secretory immunoglobulins.
摘要翻译： 该应用提供具有新颖设计的Fc融合蛋白。 在一个实施方案中，本申请提供包含10Fn3结构域的Fc融合蛋白。 在另一个实施方案中，本申请提供Fc融合蛋白，其包含衍生自膜结合或分泌免疫球蛋白的天然存在的C末端尾区的接头。
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17.发明申请公开(公告)号：US20130184212A1
公开(公告)日：2013-07-18
申请号：US13699458
申请日：2011-05-26
申请人： Ray Camphausen , John O'Loughlin , Bernice Yeung , Yihong Zhang
发明人： Ray Camphausen , John O'Loughlin , Bernice Yeung , Yihong Zhang
IPC分类号： C07K14/78
CPC分类号： C07K14/78 , A61K38/00 , C07K14/71 , C07K14/7155 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/94 , C07K2318/20 , C07K2319/00 , C07K2319/30
摘要： The present application provides fibronectin based scaffold proteins associated with improved stability. The application also relates to stable formulations of fibronectin based scaffold proteins and the use thereof in diagnostic, research and therapeutic applications. The application further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising such polynucleotides.
摘要翻译： 本申请提供与改善的稳定性相关的基于纤连蛋白的支架蛋白。 该应用还涉及基于纤维连接蛋白的支架蛋白的稳定制剂及其在诊断，研究和治疗应用中的用途。 本申请还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含这种多核苷酸的载体。
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18.发明申请公开(公告)号：US20120094909A1
公开(公告)日：2012-04-19
申请号：US13085864
申请日：2011-04-13
申请人： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
发明人： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC分类号： C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
摘要： The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
摘要翻译： 本发明涉及结合PCSK9的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新的蛋白质在治疗应用中用于治疗动脉粥样硬化，高胆固醇血症和其它胆固醇相关疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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19.发明申请TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS FOR TYROSINE KINASES RECEPTORS, INCLUDING IGF-IR 有权基于酪氨酸激酶受体的工程化蛋白质的针对性治疗剂，包括IGF-IR公开(公告)号：US20100121033A1
公开(公告)日：2010-05-13
申请号：US12312725
申请日：2007-11-21
IPC分类号： C07K14/765 , C07K14/00 , C07K16/00 , C07K14/79
CPC分类号： C07K14/78 , A61K38/18 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , C07K2319/74 , C12N15/1062 , C40B30/04 , C40B40/08 , C40B40/10
摘要： The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
摘要翻译： 本发明提供了与胰岛素样生长因子-I受体（IGF-1R）以及其它重要蛋白质结合的创新蛋白质。 本发明还提供药物制剂中的创新蛋白质和这种蛋白质的衍生物及其在诊断，研究和治疗应用中的用途。 本发明还提供包含这些蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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