公开(公告)号：US20110256115A1

公开(公告)日：2011-10-20

申请号：US13140181

申请日：2009-12-22

申请人： Daniel Auriol ,  Aurélien Ginolhac ,  Fabrice Lefevre ,  Renaud Nalin

发明人： Daniel Auriol ,  Aurélien Ginolhac ,  Fabrice Lefevre ,  Renaud Nalin

IPC分类号： A61K35/74 ,  A61K31/704 ,  A61K38/47 ,  A61P17/00 ,  A61P9/00 ,  A61P31/04 ,  A61P37/08 ,  A61P29/00 ,  C07H15/24 ,  A61P35/00

CPC分类号： C07H15/203 ,  A61K8/602 ,  A61K2800/522 ,  A61Q19/00 ,  C07H15/26

摘要： The invention relates to [6)O-α-D-Glcp-(1→]n-6-O-β-D-Glcp-(1→-phenolic derivatives. These [6)O-α-D-Glcp-(1→]n-6-O-β-D-Glcp-(1→-phenolic derivatives of selected phenolics are new, have a solubility in water higher than that of their parent O-β-D-Glcp-(1→-phenolic derivatives and have useful applications in cosmetic, nutrition and pharmaceutical compositions, such as treating or preventing oxidative stress, a cancer, a cardiovascular disease, a bacterial infection, a viral infection, a fungal infection, a UV-induced erythema, an allergy, a metabolism disorder, diabetes, an obesity, a hormonal disorder, a bone disease, a pain, a brain disease, a mouth or teeth disease, an inflammatory or immune disorder.

摘要翻译： 本发明涉及[6] O-α-D-Glcp-（1→] n-6-O-和bgr-D-Glcp-（1→ - 酚衍生物），这些[6] O-α-D-Glcp - （1→] n-6-O-＆bgr; -D-Glcp-（1→所选酚类的酚衍生物是新的，在水中的溶解度高于其亲本O-＆bgr; -D-Glcp- （1→酚衍生物，并且在化妆品，营养和药物组合物中有用，例如治疗或预防氧化应激，癌症，心血管疾病，细菌感染，病毒感染，真菌感染，紫外线诱发的红斑 ，过敏，代谢障碍，糖尿病，肥胖，激素失调，骨病，疼痛，脑疾病，口腔或牙齿疾病，炎症或免疫疾病。

公开(公告)号：US20090233876A1

公开(公告)日：2009-09-17

申请号：US12304212

申请日：2007-06-13

申请人： Daniel Auriol ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

发明人： Daniel Auriol ,  Renaud Nalin ,  Patrick Robe ,  Fabrice Lefevre

IPC分类号： A61K31/7048 ,  C12P19/60 ,  C07H17/06 ,  A61P35/00

CPC分类号： C07H17/075 ,  C07H15/203 ,  C07H15/24 ,  C07H15/26 ,  C12P17/02 ,  C12P19/02 ,  C12P19/44 ,  C12P19/60

摘要： The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application.

摘要翻译： 本发明涉及通过将选自邻苯二酚或其衍生物的酚类与蔗糖的葡萄糖部分的酶缩合制备酚衍生物。 所述酚衍生物的生产通过葡糖基转移酶（EC 2.4.1.5）来实现。 所选择的酚类的这些O-α-葡萄糖苷是新的，在水中的溶解度高于其亲本多酚的溶解度，并且在化妆品和药物组合物中有用，例如抗氧化，抗病毒，抗菌，免疫刺激，抗过敏，抗高血压， 抗缺血性，抗心律不齐，抗血栓形成，低胆固醇血症，抗脂质过氧化物，肝保护，抗炎，抗致癌性抗诱发剂，抗肿瘤剂，抗血栓形成和血管扩张制剂，或在任何其他应用领域。

公开(公告)号：US06989249B2

公开(公告)日：2006-01-24

申请号：US10282190

申请日：2002-10-28

申请人： Renaud Nalin ,  Patrick Robe ,  Van Tran Van

发明人： Renaud Nalin ,  Patrick Robe ,  Van Tran Van

IPC分类号： C12P19/34 ,  C12N1/08 ,  C07H21/00 ,  C07H1/08

CPC分类号： G01N27/44773 ,  C12N15/1003

摘要： A method for the indirect extraction of DNA greater than 300 kb in size from non-cultivatable organisms contained in an environmental sample is disclosed. The method comprises isolating the organisms from the sample and embedding the isolated organisms in a block of agarose where the organisms are subsequently lysed and the DNA subjected to a first alternating field electrophoresis to extract DNA fragments which are large in size and separate them from the cell debris. The first electrophoretic migration is followed by an enzymatic restriction step and additional electrophoretic migrations. The invention also encompasses DNA obtained by the method.