公开(公告)号：US20190263781A1

公开(公告)日：2019-08-29

申请号：US16333849

申请日：2017-09-15

Applicant: Research Triangle Institute

Inventor： Frank Ivy Carroll ,  Chad M. Kormos ,  Pauline W. Ondachi ,  Scott P. Runyon ,  Hernan A. Navarro ,  James B. Thomas ,  S. Wayne Mascarella

IPC: C07D401/12 ,  C07D413/12 ,  A61P25/18 ,  A61P25/24 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  C07D217/26 ,  C07D211/18

Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.

公开(公告)号：US09512105B2

公开(公告)日：2016-12-06

申请号：US14364003

申请日：2012-12-10

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Frank I. Carroll ,  James B. Thomas ,  Hernan A. Navarro ,  S. Wayne Mascarella ,  Scott P. Runyon ,  Chunyang Jin ,  Chad M. Kormos

IPC: C07D241/04 ,  C07D401/12 ,  C07D295/13

CPC classification number: C07D401/12 ,  C07D241/04 ,  C07D295/13

Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.

公开(公告)号：US11292783B2

公开(公告)日：2022-04-05

申请号：US16333849

申请日：2017-09-15

Applicant: Research Triangle Institute

Inventor： Frank Ivy Carroll ,  Chad M. Kormos ,  Pauline W. Ondachi ,  Scott P. Runyon ,  Hernan A. Navarro ,  James B. Thomas ,  S. Wayne Mascarella

IPC: A61K31/472 ,  C07D217/26 ,  C07D401/12 ,  A61P25/34 ,  A61P25/36 ,  A61P25/32 ,  A61P25/18 ,  A61P25/24 ,  C07D211/18 ,  C07D413/12 ,  C07D487/08 ,  A61P25/00

Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.

公开(公告)号：US10377718B2

公开(公告)日：2019-08-13

申请号：US15023510

申请日：2015-06-05

Applicant: Research Triangle Institute ,  Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas

IPC: C07D231/14 ,  A61K45/06 ,  A61K31/415 ,  C07D405/12 ,  A61K31/422 ,  A61K31/454 ,  A61K31/4155 ,  A61K31/496 ,  C07D413/12 ,  C07D403/12 ,  C07D403/06 ,  C07D407/12

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20170166577A1

公开(公告)日：2017-06-15

申请号：US15374386

申请日：2016-12-09

Applicant: Research Triangle Institute

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas ,  Kenneth S. Rehder ,  Srinivas Olepu

IPC: C07D491/107 ,  A61K31/454 ,  C07D231/14 ,  A61K31/415 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/4439 ,  C07D401/12 ,  C07D401/14 ,  A61K31/55 ,  C07D487/08 ,  C07D405/12 ,  A61K31/427 ,  C07D417/12 ,  A61K31/422 ,  C07D413/12 ,  C07D409/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  A61K31/4196 ,  A61K31/4245 ,  C07D403/14 ,  C07D403/12 ,  A61K31/439 ,  C07D471/08 ,  A61K45/06

CPC classification number: C07D491/107 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.