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11.发明授权Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles 有权包含电荷稳定的含氧纳米气泡的离子水溶液公开(公告)号：US09511333B2
公开(公告)日：2016-12-06
申请号：US13851888
申请日：2013-03-27
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized with molecular oxygen.
摘要翻译： 提供了电动改变的流体（例如，富含气体（例如富氧）电动流体），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以在与电池接触时提供调制 细胞膜电位和细胞膜电导率中的至少一种。 进一步提供制备电动改性的离子水性液体组合物的方法。 特定方面提供调节或调节与细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G蛋白偶联受体（GPCR））和细胞间结合（例如，细胞间接合）中的至少一种调节相关的细胞内信号转导。 ，紧密连接处，间隙连接处，扎胶粘合剂和粘胶）。 其它实施方案包括产生电动改变的流体的特定方法。 电动改变的流体组合物和制备流体的方法包括任选地以分子氧稳定的溶剂化电子的形式的电动改变的离子水性流体。
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12.发明申请COMPOSITIONS AND METHODS FOR TREATING INSULIN RESISTANCE AND DIABETES MELLITUS 有权用于治疗胰岛素抵抗和糖尿病的组合物和方法公开(公告)号：US20150050346A1
公开(公告)日：2015-02-19
申请号：US14467821
申请日：2014-08-25
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/08 , A61K9/14 , A61K31/138 , A61K31/45 , A61K31/58 , A61K41/00 , A61K41/0004 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating diabetes and diabetes-associated conditions or disorders (e.g., insulin resistance), or symptoms thereof. Provided are electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译： 提供了电动改变的流体（富含气体的电动液），其包含足以提供细胞膜电位和细胞膜电导率中的至少一种的调节的电荷稳定的含氧纳米结构的离子水溶液，以及治疗组合物和 用于治疗糖尿病和糖尿病相关病症或障碍（例如，胰岛素抵抗）的方法或其症状。 提供任选与其它治疗剂组合的电动学改变的碘含量水性流体。 特定方面通过调节细胞膜，膜电位，膜蛋白例如膜受体（包括但不限于G-蛋白偶联受体（GPCR））和细胞间质细胞间的至少一种来调节或调节与所述应答相关的细胞内信号转导 交界处（例如，紧密连接处，间隙连接处，粘合层和脱水垫）。 其他实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。
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公开(公告)号：US20140086963A1
公开(公告)日：2014-03-27
申请号：US14091192
申请日：2013-11-26
IPC分类号： A61K33/00
CPC分类号： A61K9/0014 , A61K9/0048 , A61K33/00 , A61K33/14 , A61K45/06 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29D11/00038 , B29D11/00096 , A61K2300/00
摘要： Particular embodiments disclosed herein relate to gas-enriched fluids, methods of making the same, systems for making the same and/or methods of treatment utilizing the gas-enriched fluids for wound care related conditions and/or diseases. In certain embodiments, the gas-enriched fluid is oxygen-enriched water. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids in order to treat a cosmetic and/or therapeutic symptom of wound care and/or increase proper wound healing.
摘要翻译： 本文公开的具体实施方案涉及富含气体的流体，其制备方法，制备方法，和/或利用富含气体的流体处理伤口护理相关病症和/或疾病的治疗方法。 在某些实施方案中，富含气体的流体是富氧水。 某些实施方案涉及使用流体的化妆品和/或治疗性流体和/或治疗方法，以便治疗伤口护理的化妆品和/或治疗症状和/或增加适当的伤口愈合。
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14.发明申请COMPOSITIONS AND METHODS FOR ENHANCING PHYSIOLOGICAL PERFORMANCE AND RECOVERY TIME 审中-公开用于增强生理性能和恢复时间的组合物和方法公开(公告)号：US20160271166A1
公开(公告)日：2016-09-22
申请号：US14948191
申请日：2015-11-20
CPC分类号： A61K33/00 , A23L2/54 , A23L33/10 , A23V2002/00 , A61K9/0053 , A61K9/08 , A61K33/14 , A61K41/0004 , A23V2200/25 , A23V2200/33 , A23V2250/126
摘要： Provided are methods for enhancing exercise (e.g., intense, eccentric, elevated temperature, repetitive, aerobic, and high altitude) performance, comprising administering electrokinetically-altered aqueous fluids comprising an ionic aqueous solution of stably configured charge-stabilized oxygen-containing nanostructures predominantly having an average diameter of less than 100 nanometers. In certain aspects, enhancing exercise performance comprises at least one of: reducing plasma inflammatory cytokines (e.g., IFN-alpha, ENA-78 and BDNF); ameliorating muscle/tendon damage or enhancing muscle/tendon recovery; reducing biomarkers of exercise-induced muscle injury (e.g., CK, plasma myoglobin); ameliorating exercise induced tendinosis, tendonitis, tenosynovitis, avulsion, and tendon strain associated with chronic repetitive movement or enhancing recovering therefrom; increasing VO2 max; decreasing RPE; reducing blood lactate; preserving muscle contractile function (e.g., maximal force, joint ROM); reducing muscle soreness; ameliorating onset of fatigue in an exercising subject. Improved methods for producing electrokinetically altered aqueous fluids (including sports beverages) are also provided.
摘要翻译： 提供了用于增强运动（例如，强烈，偏心，升高的温度，重复，有氧和高海拔）性能的方法，包括施用电动改变的含水流体，其包含稳定配置的电荷稳定的含氧纳米结构的离子水溶液，其主要具有 平均直径小于100纳米。 在某些方面，增强运动性能包括降低血浆炎性细胞因子（例如IFN-α，ENA-78和BDNF）中的至少一种; 改善肌肉/肌腱损伤或增强肌肉/肌腱恢复; 减少运动性肌肉损伤的生物标志物（例如，CK，血浆肌红蛋白）; 改善运动诱导的腱鞘炎，腱炎，腱鞘炎，撕脱和与慢性重复运动相关的肌腱菌株或增强其从其中的恢复; 增加VO2 max; 减少RPE; 减少血液乳酸盐 保持肌肉收缩功能（例如，最大力，关节ROM）; 减轻肌肉酸痛; 改善运动受试者的疲劳发作。 还提供了用于生产电动改变的含水流体（包括运动饮料）的改进的方法。
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公开(公告)号：US09402803B2
公开(公告)日：2016-08-02
申请号：US14144227
申请日：2013-12-30
IPC分类号： A61K33/40 , A61K9/00 , A61K33/00 , A61K33/14 , A61K45/06 , B01F3/04 , B01F3/08 , B01F7/00 , B29D11/00
CPC分类号： A61K9/0014 , A61K9/0048 , A61K33/00 , A61K33/14 , A61K45/06 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29D11/00038 , B29D11/00096 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating a wound to a surface tissue or a symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译： 提供了电动改变的流体（例如，富含气体的电动液），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以提供细胞膜电位和细胞膜电导率中的至少一种的调节，以及治疗 用于治疗伤口至表面组织或其症状的组合物和方法。 电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的碘代水性流体。 特定方面提供调节或调节与所述炎症反应相关的细胞内信号转导，通过调节细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G-蛋白偶联受体（GPCR））和 细胞间连接（例如，紧密连接，间隙连接，zona adherins和desmasomes）。 其他实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。
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16.发明授权Compositions and methods for treating insulin resistance and diabetes mellitus 有权治疗胰岛素抵抗和糖尿病的组合物和方法公开(公告)号：US09272000B2
公开(公告)日：2016-03-01
申请号：US14692676
申请日：2015-04-21
CPC分类号： A61K33/14 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/08 , A61K9/14 , A61K31/138 , A61K31/45 , A61K31/58 , A61K41/00 , A61K41/0004 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating diabetes and diabetes-associated conditions or disorders (e.g., insulin resistance), or symptoms thereof. Provided are electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译： 提供了电动改变的流体（富含气体的电动液体），其包含足以提供细胞膜电位和细胞膜电导率中的至少一种的调节的电荷稳定的含氧纳米结构的离子水溶液，以及治疗组合物和 用于治疗糖尿病和糖尿病相关病症或障碍（例如，胰岛素抵抗）的方法或其症状。 提供任选与其它治疗剂组合的电动学改变的碘含量水性流体。 特定方面提供调节或调节与所述炎症反应相关的细胞内信号转导，通过调节细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G-蛋白偶联受体（GPCR））和 细胞间连接（例如，紧密连接，间隙连接，zona adherins和desmasomes）。 其他实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。
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17.发明申请COMPOSITIONS AND METHODS FOR ENHANCING NEURONAL PHOSPHORYLATION HOMEOSTASIS, AND MODULATING DYSFUNCTIONAL EXOCYTOSIS AND NEUROTRANSMITTER RELEASE 审中-公开用于增强神经磷酸化的组合物和方法，以及调节功能性外分泌和神经递质释放公开(公告)号：US20150202157A1
公开(公告)日：2015-07-23
申请号：US14603305
申请日：2015-01-22
CPC分类号： A61K33/00
摘要： Provided are methods for treating pre-neuronal loss abnormalities in synaptic function, comprising administrating to a subject having neurons, an ionic aqueous solution comprising charge-stabilized oxygen-containing nanostructures having an average diameter of less than 100 nm in an amount and for a time period sufficient for preventing or reducing abnormalities in synaptic function that precede neuronal loss and/or NFTs formation in taupathies. Also provided are methods for treating pre-neuronal loss abnormalities in synaptic function, comprising contacting neurons in vitro or ex vivo with an ionic aqueous solution comprising charge-stabilized oxygen-containing nanostructures having an average diameter of less than 100 nm in an amount and for a time period sufficient for preventing or reducing abnormalities in synaptic function that precede neuronal loss and/or NFTs formation.
摘要翻译： 提供了用于治疗突触功能中的神经元前损失异常的方法，包括向具有神经元的受试者施用包含平均直径小于100nm的电荷稳定的含氧纳米结构的离子水溶液，其量和一段时间 足以预防或减少先天性神经元损失和/或NFTs形成的突触功能的异常。 还提供了用于治疗突触功能中的神经元前损失异常的方法，其包括将体外或离体的神经元与包含平均直径小于100nm的电荷稳定的含氧纳米结构的离子水溶液接触，所述电荷稳定的含氧纳米结构的量为 足以预防或减少在神经元损失和/或NFT形成之前的突触功能异常的时间段。
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18.发明授权Mixing device for creating an output mixture by mixing a first material and a second material 有权混合装置，用于通过混合第一材料和第二材料来产生输出混合物公开(公告)号：US09004743B2
公开(公告)日：2015-04-14
申请号：US13902663
申请日：2013-05-24
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： A mixing device for mixing a first and second material together to create an output mixture. The device includes a first chamber containing the first material coupled to a mixing chamber defined between a rotor and a stator. The rotor is disposed inside the stator and rotates therein about an axis of rotation. The first chamber houses an internal pump configured to pump the first material from the first chamber into the mixing chamber. The pump may be configured to impart a circumferential velocity into the first material before it enters the mixing chamber. At least one of the rotor and stator have a plurality of through-holes through which the second material is provided to the mixing chamber. Optionally, a second chamber is coupled to the mixing chamber. The second chamber may house an internal pump configured to pump the output material from the mixing chamber into the second chamber.
摘要翻译： 一种用于将第一和第二材料混合在一起以产生输出混合物的混合装置。 该装置包括第一室，该第一室包含耦合到限定在转子和定子之间的混合室的第一材料。 转子设置在定子内部并绕其旋转轴线旋转。 第一室容纳内部泵，其构造成将第一材料从第一室泵送到混合室中。 泵可以构造成在其进入混合室之前将圆周速度赋予第一材料。 转子和定子中的至少一个具有多个通孔，第二材料通过该通孔提供给混合室。 可选地，第二室耦合到混合室。 第二室可以容纳内部泵，其构造成将输出材料从混合室泵入第二室。
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19.发明授权Electrokinetically-altered fluids comprising charge-stabilized gas-containing nanostructures 有权包含电荷稳定的含气体纳米结构的电动改性流体公开(公告)号：US08962700B2
公开(公告)日：2015-02-24
申请号：US13924295
申请日：2013-06-21
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0.5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0.01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0.1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid.
摘要翻译： 具体方面提供了包含电动改变的含氧水溶液的组合物，其中流体中的氧以至少25ppm的量存在。 在某些方面，电动改变的含氧水性流体包含以至少0.5ppm的量存在的电动改性或带电的氧物质。 在某些方面，电动改变的含氧水性流体包含由分子氧稳定的溶剂化电子，并且其中溶剂化电子以至少0.01ppm的量存在。 在某些方面，流体有助于在辣根过氧化物酶（HRP）存在下将连苯三酚氧化成紫罗卜糖苷，其量高于由产生的对照压力罐或具有等效溶解氧水平的微小气泡产生的水性流体所提供的量，并且其中 在电动性富氧水溶液中不存在过氧化氢或少于0.1ppm的过氧化氢。
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公开(公告)号：US20150024010A1
公开(公告)日：2015-01-22
申请号：US14336307
申请日：2014-07-21
CPC分类号： A61K33/40 , A01N1/0226 , A61K9/0048 , A61K9/10 , A61K9/5115 , A61K31/573 , A61K33/00 , A61K45/06 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , A61K2300/00
摘要： Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating an irritation, infection or inflammatory eye condition, comprising administering to, by contacting the eye of a subject in need thereof a therapeutically effective amount of an electrokinetically-altered aqueous fluid. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids) and therapeutic compositions for use in treating eye conditions. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.
摘要翻译： 提供了电动改变的含水流体（例如，富含气体的电动液），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以提供细胞膜电位和细胞膜电导率中的至少一种的调节，以及 治疗组合物和用于治疗刺激性，感染性或炎症性眼病症的方法，包括通过使需要的受试者的眼睛接触治疗有效量的电动改变的水性液体来施用。 电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的碘代水性流体。 其它实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体）的特定施用途径或制剂以及用于治疗眼睛状况的治疗组合物。 某些实施方案涉及使用流体处理与眼睛条件和/或疾病相关的化妆品和/或治疗症状的化妆品和/或治疗流体和/或治疗方法。
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