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公开(公告)号：US20100261760A1
公开(公告)日：2010-10-14
申请号：US12820752
申请日：2010-06-22
申请人： Alexander William Oxford , Richard John Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd , Shirley Ann Brunton
发明人： Alexander William Oxford , Richard John Davis , Robert Alexander Coleman , Kenneth Lyle Clark , David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Mark Richard Ashton , Edward Andrew Boyd , Shirley Ann Brunton
IPC分类号： A61K31/4439 , A61K31/4418 , A61K31/381 , A61K31/36 , A61K31/341 , C07D401/12 , C07D213/81 , C07D333/38 , C07D407/10 , C07D307/54 , A61P13/12 , A61P15/00 , A61P27/06 , A61P19/10 , A61P11/06 , A61P37/00
CPC分类号： C07D213/81 , C07C233/75 , C07C233/81 , C07C235/84 , C07D233/90 , C07D257/04 , C07D277/24 , C07D277/26 , C07D277/56 , C07D307/46 , C07D307/68 , C07D307/91 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要： The disclosure provides EP2 receptor agonist compounds and methods for using the compounds for treating conditions which can be alleviated by agonism of an EP2 receptor.
摘要翻译： 本公开提供EP2受体激动剂化合物和使用该化合物治疗可通过EP2受体激动作用缓解的病症的方法。
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公开(公告)号：US07569602B2
公开(公告)日：2009-08-04
申请号：US10576095
申请日：2004-10-15
申请人： David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
发明人： David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
IPC分类号： A61K31/341 , C07D307/34
CPC分类号： C07D307/68
摘要： A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译： 式（I）化合物或其盐，溶剂合物和化学保护形式，其中R 2和R 5之一为：（ⅰ）H或任选取代的C 1-4烷基; 或（ii）任选取代的C 5-7芳基; R2和R5中的另一个为另一组; m和n可以是0或1，并且m + n = 1或2个RN是H或任选取代的C 1-4烷基R 3是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20芳基或NRN 3 R N 4，其中RN 3和RN 4独立地选自任选取代的 C 1-4烷基; 或（iv）四唑-5-基。
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公开(公告)号：US20080306117A1
公开(公告)日：2008-12-11
申请号：US12186308
申请日：2008-08-05
申请人： David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
发明人： David Edward Clark , Neil Victor Harris , Garry Fenton , George Hynd , Keith Alfred James Stuttle , Jonathan Mark Sutton , Alexander William Oxford , Richard Jon Davis , Robert Alexander Coleman , Kenneth Lyle Clark
IPC分类号： A61K31/443 , C07D307/34 , A61K31/341 , C07D261/06 , A61P29/00 , A61K31/422 , C07D405/02
CPC分类号： C07D307/68
摘要： A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein one of R2 and R5 is: (i) H or an optionally substituted C1-4 alkyl group; or (ii) an optionally substituted C5-7 aryl; and the other of R2 and R5 is the other group; m and n can be 0 or 1, and m+n=1 or 2 RN is H or optionally substituted C1-4 alkyl R3 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl, or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; or (iv) tetrazol-5-yl.
摘要翻译： 式（I）化合物或其盐，溶剂合物和化学保护形式，其中R 2和R 5之一为：（ⅰ）H或任选取代的C 1-4烷基; 或（ii）任选取代的C 5-7芳基; R2和R5中的另一个为另一组; m和n可以是0或1，并且m + n = 1或2个RN是H或任选取代的C 1-4烷基R 3是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20芳基或NRN 3 R N 4，其中RN 3和RN 4独立地选自任选取代的 C 1-4烷基; 或（iv）四唑-5-基。
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公开(公告)号：US20080045596A1
公开(公告)日：2008-02-21
申请号：US10583896
申请日：2004-12-22
申请人： Richard Anthony Borman , Robert Alexander Coleman , Kenneth Lyle Clark , Keith Mills , Alexander William Oxford , Jian Zhang , Peter Thomas Duff
发明人： Richard Anthony Borman , Robert Alexander Coleman , Kenneth Lyle Clark , Keith Mills , Alexander William Oxford , Jian Zhang , Peter Thomas Duff
IPC分类号： C07C59/48 , A61K31/192 , A61P11/00 , A61P17/06 , A61P37/00
CPC分类号： C07C59/90 , C07C405/0025
摘要： A compound selected from one of the following: or a salt, solvate, chemically protected form or prodrug thereof, and its use in treating conditions alleviated by agonism of an EP2 receptor.
摘要翻译： 选自以下之一的化合物或其盐，溶剂合物，化学保护形式或前药，以及其用于治疗由受体受体拮抗剂缓解的病症的用途。
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公开(公告)号：US08377248B2
公开(公告)日：2013-02-19
申请号：US12816568
申请日：2010-06-16
CPC分类号： B29C33/448 , B29C33/3842 , B29C70/443 , B29C70/446 , B29L2031/737
摘要： A system and method for forming a hollow, complex, monolithic composite part. Composite material may be placed around the mandrel, then an internal impermeable membrane may be placed into and/or through tunnels formed in the mandrel. Next, an external impermeable membrane may be placed around the composite material and sealed against itself and the internal impermeable membrane such that the mandrel and the composite material are both contained in an airtight manner between the internal and external impermeable membranes. Air may then be removed from within the sealed impermeable membranes, compressing the impermeable membranes against the mandrel and/or the composite material. The consolidated composite material may be hardened to form the composite part. Finally, the impermeable membrane may be removed from around the hollow composite part and from within the mandrel, followed by removal of the mandrel from within the composite part by breaking it up into smaller pieces.
摘要翻译： 一种用于形成中空复合整体复合材料部件的系统和方法。 可以将复合材料放置在心轴周围，然后将内部不可渗透的膜放置在形成在心轴中的通道中和/或穿过该通孔中。 接下来，外部不可渗透的膜可以放置在复合材料周围并且被密封抵抗其自身和内部不可渗透的膜，使得心轴和复合材料都以内部和外部不可渗透膜之间的气密方式包含。 然后可以从密封的不可渗透膜中除去空气，将不透水膜压靠在心轴和/或复合材料上。 固结的复合材料可以被硬化以形成复合部件。 最后，不可渗透的膜可以从中空复合材料部件周围和芯棒内部移除，然后通过将其分解成较小的部件从复合材料部件中除去心轴。
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公开(公告)号：US20110308711A1
公开(公告)日：2011-12-22
申请号：US12816568
申请日：2010-06-16
IPC分类号： B29C53/50
CPC分类号： B29C33/448 , B29C33/3842 , B29C70/443 , B29C70/446 , B29L2031/737
摘要： A system and method for forming a hollow, complex, monolithic composite part. Composite material may be placed around the mandrel, then an internal impermeable membrane may be placed into and/or through tunnels formed in the mandrel. Next, an external impermeable membrane may be placed around the composite material and sealed against itself and the internal impermeable membrane such that the mandrel and the composite material are both contained in an airtight manner between the internal and external impermeable membranes. Air may then be removed from within the sealed impermeable membranes, compressing the impermeable membranes against the mandrel and/or the composite material. The consolidated composite material may be hardened to form the composite part. Finally, the impermeable membrane may be removed from around the hollow composite part and from within the mandrel, followed by removal of the mandrel from within the composite part by breaking it up into smaller pieces.
摘要翻译： 一种用于形成中空复合整体复合材料部件的系统和方法。 可以将复合材料放置在心轴周围，然后将内部不可渗透的膜放置在形成在心轴中的通道中和/或穿过该通孔中。 接下来，外部不可渗透的膜可以放置在复合材料周围并且被密封抵抗其自身和内部不可渗透的膜，使得心轴和复合材料都以内部和外部不可渗透膜之间的气密方式包含。 然后可以从密封的不可渗透膜中除去空气，将不透水膜压靠在心轴和/或复合材料上。 固结的复合材料可以被硬化以形成复合部件。 最后，不可渗透的膜可以从中空复合材料部件周围和芯棒内部移除，然后通过将其分解成较小的部件从复合材料部件中除去心轴。
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