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11.发明申请Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20090258854A1
公开(公告)日：2009-10-15
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/437 , C07D513/04 , A61K31/506 , A61K31/5377 , A61K31/4985 , A61P29/00 , C12N9/50 , C07D453/02
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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12.发明申请Synthesis of 1,3,4-Trisubstituted and 1,3,4,5-Tetrasubstituted Pyrazoles 有权1,3,4-三取代和1,3,4,5-四取代的吡唑的合成公开(公告)号：US20090093637A1
公开(公告)日：2009-04-09
申请号：US12244184
申请日：2008-10-02
申请人： Xiaohu Deng , Neelakandha S. Mani
发明人： Xiaohu Deng , Neelakandha S. Mani
IPC分类号： C07D401/02 , C07D231/10 , C07D231/54
CPC分类号： C07D213/77 , C07D231/12 , C07D231/38 , C07D231/56 , C07D401/04 , C07D405/04 , C07D409/04
摘要： This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.
摘要翻译： 本发明涉及通过腙与硝基烯烃的反应来合成高度取代的吡唑，它是药物化合物的结构组分。
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13.发明申请Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20110159563A1
公开(公告)日：2011-06-30
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： C12N9/99 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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公开(公告)号：US07939527B2
公开(公告)日：2011-05-10
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/516 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
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公开(公告)号：US07402680B2
公开(公告)日：2008-07-22
申请号：US10941664
申请日：2004-09-15
申请人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号： C07D471/02
CPC分类号： C07D487/04
摘要： Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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公开(公告)号：US20080103300A1
公开(公告)日：2008-05-01
申请号：US11928268
申请日：2007-10-30
申请人： Xiaohu Deng , Jimmy Liang , Neelakandha Mani , Chennagiri Pandit
发明人： Xiaohu Deng , Jimmy Liang , Neelakandha Mani , Chennagiri Pandit
IPC分类号： C07D413/10 , C07D241/38 , C07D403/10
CPC分类号： C07D241/42 , C07D401/12 , C07D403/12 , C07D413/12
摘要： Certain methods that are useful in the preparation of amidophenyl-sulfonylamino-quinoxaline compounds CCK2 modulators are disclosed.
摘要翻译： 公开了可用于制备酰氨基 - 磺酰基氨基 - 喹喔啉化合物CCK2调节剂的某些方法。
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17.发明授权Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine 有权通过2,4-二氯嘧啶的顺序官能化合成4 / 5-嘧啶基咪唑公开(公告)号：US08242273B2
公开(公告)日：2012-08-14
申请号：US12831037
申请日：2010-07-06
申请人： Xiaohu Deng , Neelakandha Mani
发明人： Xiaohu Deng , Neelakandha Mani
IPC分类号： C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D239/42 , C07D403/04 , C07D403/14
摘要： This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.
摘要翻译： 本发明涉及通过4-二氯嘧啶的4-和2-氯基取代嘧啶基取代的咪唑化合物的方法，亲核取代形成嘧啶基炔衍生物，氧化成相应的1,2-二酮和环缩合 反应。
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公开(公告)号：US07915404B2
公开(公告)日：2011-03-29
申请号：US11744340
申请日：2007-05-04
申请人： Xiaohu Deng , Jimmy T. Liang , Neelakandha Mani
发明人： Xiaohu Deng , Jimmy T. Liang , Neelakandha Mani
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D317/16 , C07D405/06
摘要： The present invention is directed to novel processes for the preparation of fused pyrazole compounds, useful for the treatment of disorders and conditions mediated by serotonin receptor activity.
摘要翻译： 本发明涉及制备用于治疗由5-羟色胺受体活性介导的病症和病症的稠合吡唑化合物的新方法。
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公开(公告)号：US20090270370A1
公开(公告)日：2009-10-29
申请号：US12496866
申请日：2009-07-02
申请人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
发明人： Nicholas I. Carruthers , Wenying Chai , Xiaohu Deng , Curt A. Dvorak , Annette K. Kwok , Jimmy T. Liang , Neelakandha Mani , Dale A. Rudolph , Victoria D. Wong
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , A61K31/55 , A61K31/4162
CPC分类号： C07D487/04
摘要： Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
摘要翻译： 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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20.发明申请Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine 有权通过2,4-二氯嘧啶的顺序官能化合成4 / 5-嘧啶基咪唑公开(公告)号：US20070027319A1
公开(公告)日：2007-02-01
申请号：US11494060
申请日：2006-07-27
申请人： Xiaohu Deng , Neelakandha Mani
发明人： Xiaohu Deng , Neelakandha Mani
IPC分类号： C07D239/32
CPC分类号： C07D239/42 , C07D403/04 , C07D403/14
摘要： This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.
摘要翻译： 本发明涉及通过4-二氯嘧啶的4-和2-氯基取代嘧啶基取代的咪唑化合物的方法，亲核取代形成嘧啶基炔衍生物，氧化成相应的1,2-二酮和环缩合 反应。
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