-
1.发明申请Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20090258854A1
公开(公告)日：2009-10-15
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/437 , C07D513/04 , A61K31/506 , A61K31/5377 , A61K31/4985 , A61P29/00 , C12N9/50 , C07D453/02
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
-
2.发明申请Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20110159563A1
公开(公告)日：2011-06-30
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： C12N9/99 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
-
公开(公告)号：US07939527B2
公开(公告)日：2011-05-10
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/516 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
-
4.发明授权Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US08357684B2
公开(公告)日：2013-01-22
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Eugene Y. Cheung , Christa C. Chrovian , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener
发明人： Genesis M. Bacani , Eugene Y. Cheung , Christa C. Chrovian , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/506 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
-
5.发明申请COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 有权具有两个双熔体双组分杂化物的化合物作为LEUKOTRIENE A4水解产物的调节剂公开(公告)号：US20100292208A1
公开(公告)日：2010-11-18
申请号：US12778646
申请日：2010-05-12
申请人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, JR. , Virginia M. Tanis , John J. M. Wiener
发明人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, JR. , Virginia M. Tanis , John J. M. Wiener
IPC分类号： A61K31/397 , C07D417/14 , A61K31/428 , A61K31/454 , A61K31/5377 , A61K31/537 , A61K31/551 , A61P11/06 , A61P17/06 , A61P17/02 , A61P17/00 , A61P3/10 , A61P19/02 , A61P35/00 , A61P1/00 , A61P9/00
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.
摘要翻译： 具有两个稠合双环杂芳基部分的化合物及其药物组合物，以及将其用作白三烯A4水解酶（LTA4H）调节剂并用于治疗由LTA4H介导的疾病，病症和状况的方法。
-
6.发明授权Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase 有权具有两个稠合双环杂芳基部分的化合物作为白三烯A4水解酶的调节剂公开(公告)号：US08399465B2
公开(公告)日：2013-03-19
申请号：US12778646
申请日：2010-05-12
申请人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Virginia M. Tanis , John J. M. Wiener
发明人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Virginia M. Tanis , John J. M. Wiener
IPC分类号： A61K31/535 , A61K31/47 , A61K31/445 , A61K31/425 , C07D417/14 , C07D417/12
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.
摘要翻译： 具有两个稠合双环杂芳基部分的化合物及其药物组合物，以及将其用作白三烯A4水解酶（LTA4H）调节剂并用于治疗由LTA4H介导的疾病，病症和状况的方法。
-
公开(公告)号：US20160039790A1
公开(公告)日：2016-02-11
申请号：US14777492
申请日：2014-03-13
申请人： Wenying CHAI , Curt A. DVORAK , Wendy ECCLES , James P. EDWARDS , Steven D. GOLDBERG , Paul J. KRAWCZUK , Alec D. LEBSACK , Jing LIU , Daniel J. PIPPEL , Zachary S. SALES , Virginia M. TANIS , Mark S. TICHENOR , John J.M. WIENER , JANSSEN PHARMACEUTICA NV
发明人： Wenying Chai , Curt A. Dvorak , Wendy Eccles , James P. Edwards , Steven D. Goldberg , Paul J. Krawczuk , Alec D. Lebsack , Jing Liu , Daniel J. Pippel , Zachary S. Sales , Virginia M. Tanis , Mark S. Tichenor , John J. M. Wiener
IPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D403/12
CPC分类号： C07D401/12 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X1, X1′, X1″, R1, R2 and R3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
-
公开(公告)号：US20160046600A1
公开(公告)日：2016-02-18
申请号：US14777481
申请日：2014-03-13
申请人： Wenying CHAI , Charlotte DECKHUT , Curt A. DVORAK , Wendy ECCLES , James P. EDWARDS , Steven D. GOLDBERG , Paul J. KRAWCZUK , Alec D. LEBSACK , Jing LIU , Virginia M. TANIS , Kyle T. TARANTINO , JANSSEN PHARMACEUTICA NV
发明人： Wenying Chai , Charlotte Deckhut , Curt A. Dvorak , Wendy Eccles , James P. Edwards , Steven D. Goldberg , Paul J. Krawczuk , Alec D. Lebsack , Jing Liu , Virginia M. Tanis , Kyle T. Tarantino
IPC分类号： C07D401/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D413/14 , C07D401/14
CPC分类号： C07D417/14 , A61K31/428 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein ring A, R1, R5 and R6 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.089 秒)
