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    GDF-15 BASED MEANS AND METHODS FOR SURVIVAL AND RECOVERY PREDICTION IN ACUTE INFLAMMATION
    15.
    发明申请
    GDF-15 BASED MEANS AND METHODS FOR SURVIVAL AND RECOVERY PREDICTION IN ACUTE INFLAMMATION 审中-公开
    基于GDF-15的手段和方法，用于急性发作中的生存和恢复预测

    公开(公告)号：US20130071953A1

    公开(公告)日：2013-03-21

    申请号：US13677615

    申请日：2012-11-15

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Georg Hess ,  Andrea Horsch ,  Dietmar Zdunek

    IPC: G01N33/68

    CPC classification number: G01N33/6863 ,  G01N33/6893 ,  G01N2333/495 ,  G06F15/00

    Abstract: A method for diagnosing whether a subject suffering from an acute inflammation and in some cases systemic inflammatory response syndrome (SIRS) is at increased risk for mortality. The method comprises determining the amount of the biomarker GDF-15 in a sample of said subject and comparing said amount to a reference. The method also relates to monitoring the development of acute inflammation in a subject by determining the amount of the biomarker GDF-15 in a first and a second sample of said subject wherein said first sample has been obtained prior to said second sample and comparing the amount of GDF-15 in said first and said second sample. Further encompassed are diagnostic devices and kits for carrying out the aforementioned methods.

    Abstract translation: 用于诊断患有急性炎症的患者和在一些情况下全身性炎症反应综合征（SIRS））的死亡风险增加的方法。 该方法包括确定所述受试者的样品中生物标志物GDF-15的量并将所述量与参考值进行比较。 该方法还涉及通过确定所述受试者的第一和第二样品中的生物标志物GDF-15的量来监测受试者的急性炎症的发展，其中在所述第二样品之前已经获得所述第一样品并比较所述量 在所述第一和第二样品中的GDF-15。 进一步包括用于执行上述方法的诊断装置和试剂盒。

    PREDICTION AND RECOGNITION OF ACUTE KIDNEY INJURY AFTER SURGERY
    18.
    发明申请
    PREDICTION AND RECOGNITION OF ACUTE KIDNEY INJURY AFTER SURGERY 有权
    手术后急性KIDNEY损伤的预测和识别

    公开(公告)号：US20130122530A1

    公开(公告)日：2013-05-16

    申请号：US13713719

    申请日：2012-12-13

    Applicant: Roche Diagnostics Operations, Inc.

    Inventor： Georg Hess ,  Andrea Horsch ,  Dietmar Zdunek

    IPC: G01N33/68 ,  G01N33/74

    CPC classification number: G01N33/6893 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/47 ,  G01N2333/475 ,  G01N2800/347 ,  G01N2800/56

    Abstract: Systems, kits, and methods for predicting the risk of an adverse event related to acute kidney injury AKI as a consequence of a surgical intervention in a subject. Embodiments of the system and methods include means and steps for determining an amount of liver-type fatty acid binding protein (L-FABP) in a sample, such as a urine-sample of a subject; comparing the amounts of the L-FABP with a reference amount, and predicting the risk of an adverse event related to acute kidney injury as a consequence of surgical intervention in the subject.

    Abstract translation: 用于预测与受试者的外科手术相关的急性肾损伤AKI有关的不良事件风险的系统，试剂盒和方法。 该系统和方法的实施方案包括用于测定样品（例如受试者的尿液样品）中肝型脂肪酸结合蛋白（L-FABP）的量的方法和步骤; 将L-FABP的量与参考量进行比较，并且预测与受试者的外科手术相关的与急性肾损伤有关的不良事件的风险。

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