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11.发明申请TROPONIN AND BNP BASED DIAGNOSIS OF RISK PATIENTS AND CAUSE OF STROKE 审中-公开TROPONIN和BNP基于风险的患者和STROKE的原因的诊断公开(公告)号：US20170023588A1
公开(公告)日：2017-01-26
申请号：US15285798
申请日：2016-10-05
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Hess , Andrea Horsch , Dietmar Zdunek
IPC: G01N33/68
CPC classification number: G01N33/6887 , G01N33/54306 , G01N33/6893 , G01N2333/47 , G01N2333/4712 , G01N2800/326
Abstract: Method for determination of whether a subject suffers from intermittent atrial fibrillation based on the determination of the amount of a Troponin T in a sample in a patient suffering from atrial fibrillation using a binding assay. Kits and devices adapted to carry out the methods are also provided.
Abstract translation: 基于使用结合测定确定患有心房颤动的患者的样品中的肌钙蛋白T的量的确定，确定受试者是否患有间歇性心房颤动的方法。 还提供了适用于执行方法的套件和设备。
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12.发明申请GDF-15 BASED MEANS AND METHODS FOR SURVIVAL AND RECOVERY PREDICTION IN ACUTE INFLAMMATION 审中-公开基于GDF-15的手段和方法，用于急性发作中的生存和恢复预测公开(公告)号：US20130071953A1
公开(公告)日：2013-03-21
申请号：US13677615
申请日：2012-11-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Hess , Andrea Horsch , Dietmar Zdunek
IPC: G01N33/68
CPC classification number: G01N33/6863 , G01N33/6893 , G01N2333/495 , G06F15/00
Abstract: A method for diagnosing whether a subject suffering from an acute inflammation and in some cases systemic inflammatory response syndrome (SIRS) is at increased risk for mortality. The method comprises determining the amount of the biomarker GDF-15 in a sample of said subject and comparing said amount to a reference. The method also relates to monitoring the development of acute inflammation in a subject by determining the amount of the biomarker GDF-15 in a first and a second sample of said subject wherein said first sample has been obtained prior to said second sample and comparing the amount of GDF-15 in said first and said second sample. Further encompassed are diagnostic devices and kits for carrying out the aforementioned methods.
Abstract translation: 用于诊断患有急性炎症的患者和在一些情况下全身性炎症反应综合征（SIRS））的死亡风险增加的方法。 该方法包括确定所述受试者的样品中生物标志物GDF-15的量并将所述量与参考值进行比较。 该方法还涉及通过确定所述受试者的第一和第二样品中的生物标志物GDF-15的量来监测受试者的急性炎症的发展，其中在所述第二样品之前已经获得所述第一样品并比较所述量 在所述第一和第二样品中的GDF-15。 进一步包括用于执行上述方法的诊断装置和试剂盒。
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13.发明申请公开(公告)号：US20210164969A1
公开(公告)日：2021-06-03
申请号：US17162140
申请日：2021-01-29
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Ursula-Henrike Wienhues-Thelen , Dirk Block , Hendrik Heudig , Sabine Vogel-Ziebolz , Christine Boehm , Georg Hess , Andrea Horsch , Dietmar Zdunek
IPC: G01N33/543 , G01N33/68
Abstract: Methods and systems for diagnosing functional and/or structural abnormalities of the heart preceding heart failure, and for predicting the risk of developing heart failure, in a subject comprising measuring a cardiac troponin in a sample and comparing the measurement to a reference value. Other markers, including GDF15 and IGFBP7 are also measured in some embodiments.
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14.发明申请TROPONIN AND BNP BASED DIAGNOSIS OF RISK PATIENTS AND CAUSE OF STROKE 审中-公开TROPONIN和BNP基于风险的患者和STROKE的原因的诊断公开(公告)号：US20160011210A1
公开(公告)日：2016-01-14
申请号：US14859616
申请日：2015-09-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Hess , Andrea Horsch , Dietmar Zdunek
IPC: G01N33/68
CPC classification number: G01N33/6887 , G01N33/54306 , G01N33/6893 , G01N2333/47 , G01N2333/4712 , G01N2800/326
Abstract: Method for determination of whether a subject suffers from intermittent atrial fibrillation based on the determination of the amount of a Troponin T in a sample in a patient suffering from atrial fibrillation using a binding assay. Kits and devices adapted to carry out the methods are also provided.
Abstract translation: 基于使用结合测定确定患有心房颤动的患者的样品中的肌钙蛋白T的量的确定，确定受试者是否患有间歇性心房颤动的方法。 还提供了适用于执行方法的套件和设备。
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Patent Agency Ranking
15.发明申请TROPONIN AND BNP BASED DIAGNOSIS OF RISK PATIENTS AND CAUSE OF STROKE 审中-公开TROPONIN和BNP基于风险的患者和STROKE的原因的诊断公开(公告)号：US20140220604A1
公开(公告)日：2014-08-07
申请号：US14251803
申请日：2014-04-14
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Hess , Andrea Horsch , Dietmar Zdunek
IPC: G01N33/543
CPC classification number: G01N33/6887 , G01N33/54306 , G01N33/6893 , G01N2333/47 , G01N2333/4712 , G01N2800/326
Abstract: Method for early differentiation of whether a subject suffers from cardioembolic stroke or from non-cardioembolic ischemic stroke based on the determination of the amount of a cardiac Troponin in a sample from a subject who is suffering from ischemic stroke, the sample obtained not more than 24 hours after the onset of symptoms of ischemic stroke. Kits and devices adapted to carry out the methods are also provided.
Abstract translation: 基于确定来自患有缺血性卒中的受试者的样品中心肌肌钙蛋白的量的确定，是否受试者患有心源性中风或非心脏缺血性中风的早期分化方法，所得样本不超过24 缺血性卒中症状发作后几小时。 还提供了适用于执行方法的套件和设备。
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公开(公告)号：US20200333360A1
公开(公告)日：2020-10-22
申请号：US16916809
申请日：2020-06-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Hess , Andrea Horsch , Dietmar Zdunek
Abstract: The present invention relates to a method for diagnosing a transitory ischemic attack (TIA) in a subject who is suspected to have exhibited a transitory ischemic attack, but who did not exhibit a stroke. The method is based on the determination of the amount of NT-proANP in a sample from said subject. Moreover, the present invention is directed to a method for diagnosing an acute cerebral ischemic event in a subject based on the determination of the amounts of NT-proBNP and NT-proANP in a sample from a subject. The method further comprises the step of calculating a ratio of the amounts of NT-proBNP and NT-proANP. Further envisaged by the present invention are kits and devices adapted to carry out the method of the present invention.
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公开(公告)号：US10732188B2
公开(公告)日：2020-08-04
申请号：US14291676
申请日：2014-05-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Hess , Andrea Horsch , Dietmar Zdunek
IPC: A61K38/00 , C12Q1/68 , G01N33/567 , G01N33/74 , G01N33/68
Abstract: The present invention relates to a method for diagnosing a transitory ischemic attack (TIA) in a subject who is suspected to have exhibited a transitory ischemic attack, but who did not exhibit a stroke. The method is based on the determination of the amount of NT-proANP in a sample from said subject. Moreover, the present invention is directed to a method for diagnosing an acute cerebral ischemic event in a subject based on the determination of the amounts of NT-proBNP and NT-proANP in a sample from a subject. The method further comprises the step of calculating a ratio of the amounts of NT-proBNP and NT-proANP. Further envisaged by the present invention are kits and devices adapted to carry out the method of the present invention.
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18.发明申请GDF-15 and/or Troponin T for Predicting Kidney Failure in Heart Surgery Patients 审中-公开GDF-15和/或肌钙蛋白T预测心脏手术患者的肾衰竭公开(公告)号：US20160109464A1
公开(公告)日：2016-04-21
申请号：US14856543
申请日：2015-09-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Andrea Horsch , Dietmar Zdunek , George Hess
CPC classification number: G01N33/74 , C07K14/4716 , G01N33/6863 , G01N33/6893 , G01N2333/4712 , G01N2333/495 , G01N2333/52 , G01N2800/347 , G01N2800/50 , G01N2800/52
Abstract: The present disclosure relates to the field of laboratory diagnostics. Specifically, means and methods are disclosed for determining a patient's risk of suffering from acute kidney injury after a surgical procedure based on the detection of GDF-15, troponin T and/or a natriuretic peptide.
Abstract translation: 本公开涉及实验室诊断领域。 具体地，公开了用于基于检测GDF-15，肌钙蛋白T和/或利尿钠肽来确定在外科手术后患有急性肾损伤的患者的风险的手段和方法。
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公开(公告)号：US20140274793A1
公开(公告)日：2014-09-18
申请号：US14291676
申请日：2014-05-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Hess , Andrea Horsch , Dietmar Zdunek
CPC classification number: G01N33/74 , G01N33/6893 , G01N33/6896 , G01N2333/58 , G01N2800/2871 , G01N2800/50
Abstract: The present invention relates to a method for diagnosing a transitory ischemic attack (TIA) in a subject who is suspected to have exhibited a transitory ischemic attack, but who did not exhibit a stroke. The method is based on the determination of the amount of NT-proANP in a sample from said subject. Moreover, the present invention is directed to a method for diagnosing an acute cerebral ischemic event in a subject based on the determination of the amounts of NT-proBNP and NT-proANP in a sample from a subject. The method further comprises the step of calculating a ratio of the amounts of NT-proBNP and NT-proANP. Further envisaged by the present invention are kits and devices adapted to carry out the method of the present invention.
Abstract translation: 本发明涉及一种用于诊断怀疑显示出暂时缺血发作，但没有发生中风的受试者的暂时缺血发作（TIA）的方法。 该方法基于来自所述受试者的样品中NT-proANP的量的确定。 此外，本发明涉及基于来自受试者的样品中NT-proBNP和NT-proANP的量的确定来诊断受试者的急性脑缺血事件的方法。 该方法还包括计算NT-proBNP和NT-proANP的量的比例的步骤。 本发明进一步设想的是适用于实施本发明方法的试剂盒和装置。
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