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11.发明授权Apparatus and method for controllably affecting the temperature of FAIMS components 有权可控制地影响FAIMS部件温度的装置和方法公开(公告)号：US07112788B2
公开(公告)日：2006-09-26
申请号：US11038166
申请日：2005-01-21
IPC分类号： H01J49/28
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes providing a FAIMS analyzer region defined by a space between a first electrode surface and a second electrode surface and extending between an ion inlet end and an ion outlet end. An asymmetric waveform is applied to the first electrode surface and a compensation voltage difference is applied between the first and second electrode surfaces. An output signal is provided from a temperature sensor, the output signal relating to a temperature within the FAIMS analyzer region. In dependence upon the output signal, the temperature within the FAIMS analyzer region is controllably affected. The apparatus supports operation of FAIMS at temperatures different from the temperature of other components in a tandem multi-stage system, and supports the stable operation of FAIMS at different temperatures which increases the separation capability of FAIMS.
摘要翻译： 用于分离离子的装置包括提供由第一电极表面和第二电极表面之间的空间限定的FAIMS分析器区域，并且在离子入口端和离子出口端之间延伸。 对第一电极表面施加非对称波形，并且在第一和第二电极表面之间施加补偿电压差。 从温度传感器提供输出信号，该输出信号与FAIMS分析仪区域内的温度有关。 根据输出信号，FAIMS分析仪区域内的温度受到可控制的影响。 该装置支持在串联多级系统中与其他部件温度不同的FAIMS操作，支持FAIMS在不同温度下的稳定运行，增加了FAIMS的分离能力。
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12.发明申请Apparatus and method for controllably affecting the temperature of FAIMS components 有权可控制地影响FAIMS部件温度的装置和方法公开(公告)号：US20050167587A1
公开(公告)日：2005-08-04
申请号：US11038166
申请日：2005-01-21
CPC分类号： G01N27/624
摘要： An apparatus for separating ions includes providing a FAIMS analyzer region defined by a space between a first electrode surface and a second electrode surface and extending between an ion inlet end and an ion outlet end. An asymmetric waveform is applied to the first electrode surface and a compensation voltage difference is applied between the first and second electrode surfaces. An output signal is provided from a temperature sensor, the output signal relating to a temperature within the FAIMS analyzer region. In dependence upon the output signal, the temperature within the FAIMS analyzer region is controllably affected. The apparatus supports operation of FAIMS at temperatures different from the temperature of other components in a tandem multi-stage system, and supports the stable operation of FAIMS at different temperatures which increases the separation capability of FAIMS.
摘要翻译： 用于分离离子的装置包括提供由第一电极表面和第二电极表面之间的空间限定的FAIMS分析器区域，并且在离子入口端和离子出口端之间延伸。 对第一电极表面施加非对称波形，并且在第一和第二电极表面之间施加补偿电压差。 从温度传感器提供输出信号，该输出信号与FAIMS分析仪区域内的温度有关。 根据输出信号，FAIMS分析仪区域内的温度受到可控制的影响。 该装置支持在串联多级系统中与其他部件温度不同的FAIMS操作，支持FAIMS在不同温度下的稳定运行，增加了FAIMS的分离能力。
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公开(公告)号：US20050258359A1
公开(公告)日：2005-11-24
申请号：US11130124
申请日：2005-05-17
CPC分类号： H01J49/0018 , G01N27/624 , H01J49/167
摘要： An apparatus for multiple nano-spray delivery of a sample to FAIMS analyzer includes a micro-machined ionization source having a plurality of discrete nozzles. At least some of the discrete nozzles of the plurality are aligned one each with an ion inlet of a plurality of discrete ion inlets of the FAIMS, so that ions produced at different discrete nozzles are introduced into different portions of the FAIMS analyzer region. The ions that are introduced via each ion inlet are at least partly separated prior to adding/mixing with the ions introduced via other ion inlets. This reduces the problems of ion-ion electric repulsions that occur when ion density is high.
摘要翻译： 将样品多次纳米喷射输送到FAIMS分析仪的装置包括具有多个分立喷嘴的微加工电离源。 多个离散喷嘴中的至少一些分立喷嘴与FAIMS的多个离散入口的离子入口对齐，使得在不同离散喷嘴处产生的离子被引入FAIMS分析器区域的不同部分。 在通过其他离子入口引入的离子添加/混合之前，经由每个离子入口引入的离子至少部分地分离。 这减少了当离子密度高时发生的离子离子电排斥的问题。
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公开(公告)号：US20090127457A1
公开(公告)日：2009-05-21
申请号：US11815761
申请日：2006-02-09
IPC分类号： H01J49/34
CPC分类号： G01N27/624
摘要： A method of transmitting ions along an analyzer region between closely spaced electrodes is disclosed. The method includes providing an analyzer region for transmitting ions, the analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a pressure within at least one portion of the analyzer region, to differ from the pressure within another part of the analyzer region, and providing an electric field that is synchronized with the pressure differences to focus the ions.
摘要翻译： 公开了沿着紧密间隔的电极之间的分析器区域传输离子的方法。 该方法包括提供用于传输离子的分析器区域，与电离源流体连通的分析器区域和离子检测装置。 该方法还包括影响分析器区域的至少一部分内的压力，以与分析器区域的另一部分内的压力不同，并且提供与压力差同步的电场以聚焦离子。
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15.发明申请APPARATUS AND METHOD FOR FORMING A GAS COMPOSITION GRADIENT BETWEEN FAIMS ELECTRODES 有权用于形成FAIMS电极之间的气体组成梯度的装置和方法公开(公告)号：US20090108195A1
公开(公告)日：2009-04-30
申请号：US11816380
申请日：2006-02-17
CPC分类号： H01J49/42
摘要： A method of separating ions includes providing a FAIMS analyzer region for separating ions, the FAIMS analyzer region in fluid communication with an ionization source and with an ion detecting device. The method further includes affecting a gas composition within a first portion of the FAIMS analyzer region to be different from a gas composition within a second portion of the FAIMS analyzer region. The establishment of a gas composition gradient within the FAIMS analyzer region enhances ion focusing and ion transport efficiency.
摘要翻译： 分离离子的方法包括提供用于分离离子的FAIMS分析器区域，与电离源流体连通的FAIMS分析器区域和离子检测装置。 该方法还包括影响FAIMS分析仪区域的第一部分内的气体组成与FAIMS分析仪区域的第二部分内的气体组成不同。 在FAIMS分析仪区域内建立气体组分梯度增强了离子聚焦和离子传输效率。
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公开(公告)号：US07057166B2
公开(公告)日：2006-06-06
申请号：US10875291
申请日：2004-06-25
CPC分类号： H01J49/0031
摘要： A method of separating ions, including a first species of ion and a second species of ion that are transmitted through an analyzer region under substantially identical electrical field conditions, is provided. The method includes separating ions within an analyzer region according to the FAIMS principle, such that the first species of ion and the second species of ion are selectively transmitted along a time-averaged first direction through a portion of the analyzer region between the ion origin end and the ion detection end. Subsequently, the first species of ion and the second species of ion within the analyzer region are separated according to a difference in low field ion mobility values, such that relatively more of one of the first species of ion and the second species of ion is transmitted to an ion detection end than is transmitted absent separating the first species of ion and the second species of ion within the analyzer region according to a difference in their low field ion mobility values. The ions are transmitted through the remainder of the analyzer region under normal FAIMS operating conditions.
摘要翻译： 提供了一种分离离子的方法，包括在基本上相同的电场条件下透射通过分析器区域的第一离子类型和第二离子种类。 该方法包括根据FAIMS原理分离分析器区域内的离子，使得第一离子类型和第二离子种类沿时间平均的第一方向选择性地通过离子源端之间的分析器区域的一部分 和离子检测端。 随后，根据低场离子迁移率值的差异分离分析器区域内的第一离子种类和第二离子种类，使得离子和第二离子种类中的一种离子相对更多地被传输 相对于离子检测端而言，不是根据其低场离子迁移率值的差异而将分离器区域内的第一种离子和第二离子种分离而不发生。 在正常的FAIMS操作条件下，离子通过分析仪区域的其余部分传输。
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公开(公告)号：US07378651B2
公开(公告)日：2008-05-27
申请号：US10529307
申请日：2003-09-05
申请人： Roger Guevremont
发明人： Roger Guevremont
CPC分类号： G01N27/624
摘要： Disclosed is an apparatus for separating ions including a plurality of first electrode portions, each first electrode portion of the plurality of first electrode portions having a first length and an outer surface that is at least partially curved in a direction transverse to the first length. The apparatus also includes a plurality of second electrode portions arranged in an alternating sequence with the plurality of first electrode portions, each second electrode portion of the plurality of second electrode portions having a second length and an outer surface that is curved in a direction transverse to the second length, a space between the outer surface of a first electrode portion and the outer surface of an adjacent second electrode portion defining a portion of an analytical gap for separating ions. At least an electrical controller is provided for electrically coupling to at least one of the plurality of first electrode portions and the plurality of second electrode portions, for applying an asymmetric waveform voltage between the at least one of the plurality of first electrode portions and the plurality of second electrode portions and for applying a direct current voltage between the at least one of the plurality of first electrode portions and the plurality of second electrode portions so as to establish an electric field within the portion of the analytical gap. During use, ions propagating along a direction that is transverse to both the first length and the second length are separated in the portion of the analytical gap between the outer surface of the first electrode portion and the outer surface of the adjacent second electrode portion.
摘要翻译： 公开了一种用于分离包括多个第一电极部分的离子的装置，多个第一电极部分中的每个第一电极部分具有第一长度，并且外表面在横向于第一长度的方向上至少部分地弯曲。 该装置还包括与多个第一电极部分交替地排列的多个第二电极部分，多个第二电极部分的每个第二电极部分具有第二长度，并且外表面在横向于 第二长度，第一电极部分的外表面与限定用于分离离子的分析间隙的一部分的相邻的第二电极部分的外表面之间的空间。 至少提供电控制器以电耦合到多个第一电极部分和多个第二电极部分中的至少一个，用于在多个第一电极部分和多个第一电极部分中的至少一个之间施加非对称波形电压 并且用于在所述多个第一电极部分中的所述至少一个与所述多个第二电极部分之间施加直流电压，以便在所述分析间隙的所述部分内建立电场。 在使用过程中，沿着横向于第一长度和第二长度的方向传播的离子在第一电极部分的外表面和相邻的第二电极部分的外表面之间的分析间隙的部分中分离。
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公开(公告)号：US07225096B2
公开(公告)日：2007-05-29
申请号：US10529305
申请日：2003-09-05
申请人： Roger Guevremont , Lucien Potvin
发明人： Roger Guevremont , Lucien Potvin
IPC分类号： G01R35/00
CPC分类号： G01R19/2506
摘要： Disclosed is a method of controlling an asymmetric waveform generated as a combination of two sinusoidal waves having a frequency that differs by a factor of two. A method according to the instant invention includes a step of sampling a generated asymmetric waveform to obtain a set of data points, the set of data points being indicative of the generated asymmetric waveform. The sampled data points are arranged in an order according to magnitude, and then compared to template data relating to a desired asymmetric waveform. In dependence upon the comparison, a correction to the generated asymmetric waveform is determined.
摘要翻译： 公开了一种控制作为两个正弦波的组合产生的非对称波形的方法，该两个正弦波具有两倍的频率。 根据本发明的方法包括对生成的非对称波形进行采样以获得一组数据点的步骤，所述数据点集合指示所生成的不对称波形。 采样的数据点按照大小按顺序排列，然后与与期望的非对称波形有关的模板数据进行比较。 根据比较，确定对所生成的非对称波形的校正。
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公开(公告)号：US07084394B2
公开(公告)日：2006-08-01
申请号：US10529308
申请日：2003-08-28
申请人： Roger Guevremont , Lucien Potvin
发明人： Roger Guevremont , Lucien Potvin
IPC分类号： H01J49/00
CPC分类号： H01J49/42
摘要： A method of controlling an asymmetric waveform that is generated as a combination of a plurality of sinusoidal waves, including two sinusoidal waves having a frequency that differs by a factor of two. The method includes the steps of sampling the generated asymmetric waveform to obtain a set of data points that is indicative of the generated asymmetric waveform. Each data point of the set of data points normalized. The method further includes the steps of determining at least a value relating to the normalized data points of comparing the determined at least a value to template data relating to an ideal asymmetric waveform, and of effecting a change to the generated asymmetric waveform in dependence upon the comparison.
摘要翻译： 一种控制作为多个正弦波的组合产生的非对称波形的方法，包括具有两倍的频率的两个正弦波。 该方法包括以下步骤：对生成的非对称波形进行采样以获得指示所生成的不对称波形的一组数据点。 数据点集合中的每个数据点被归一化。 该方法还包括以下步骤：至少确定与归一化数据点有关的值，以将所确定的至少一个值与与理想非对称波形相关的模板数据进行比较，以及根据所生成的非对称波形对所生成的非对称波形进行改变 比较。
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公开(公告)号：US20060097156A1
公开(公告)日：2006-05-11
申请号：US10529306
申请日：2003-07-10
申请人： Roger Guevremont
发明人： Roger Guevremont
IPC分类号： B01D59/44
CPC分类号： G01N27/624
摘要： A high field asymmetric waveform ion mobility spectrometer (FAIMS) for separating ions, and a method therefore. The FAIMS includes an electrode stack (24) having a length and comprising a plurality of electrodes (26, 28). Each electrode of the electrode stack is spaced apart from an adjacent electrode in a direction along the length of the electrode stack, and each electrode of the electrode stack has an edge that defines a portion of an edge of the electrode stack. At least an electrode (22) is spaced apart from the edge of the electrode stack in a direction approximately transverse to the length of the electrode stack, the space between the at least an electrode and the edge of the electrode stack defines an analytical gap (20) for allowing ions to propagate therebetween. Ions are separated as they move through an electric field within the analytical gap resulting from the application of an asymmetric waveform voltage to alternate electrodes of the electrode stack and application of a direct current voltage to at least some of the electrodes of the electrode stack and to the at least an electrode.
摘要翻译： 用于分离离子的高场非对称波形离子迁移谱仪（FAIMS）及其方法。 FAIMS包括具有长度并包括多个电极（26,28）的电极堆叠（24）。 电极堆叠的每个电极在沿着电极堆叠的长度的方向上与相邻电极间隔开，并且电极堆叠的每个电极具有限定电极堆叠的边缘的一部分的边缘。 至少电极（22）在大致横向于电极堆叠长度的方向上与电极堆叠的边缘间隔开，至少电极和电极堆叠边缘之间的空间限定分析间隙（ 20），用于允许离子在其间传播。 当分离间隙中的电场移动时，由于将非对称波形电压施加到电极堆叠的交替电极并且将直流电压施加到电极堆叠的至少一些电极并且向 所述至少一个电极。
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