Compositions and methods for inhibiting viral replication
    11.
    发明授权
    Compositions and methods for inhibiting viral replication 有权
    用于抑制病毒复制的组合物和方法

    公开(公告)号:US07348314B2

    公开(公告)日:2008-03-25

    申请号:US10384512

    申请日:2003-03-07

    IPC分类号: A61K31/70 C07H21/04 C07H21/00

    摘要: The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.

    摘要翻译: 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸(dsRNA),并且其基本上与3'非翻译区(3'-UTR)的至少一部分相同 (+)链RNA病毒,例如HCV,以及包含dsRNA的药物组合物,以及药学上可接受的载体。 药物组合物可用于治疗由(+)链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。

    Compositions and methods for inhibiting expression of a mutant gene
    15.
    发明授权
    Compositions and methods for inhibiting expression of a mutant gene 有权
    用于抑制突变基因表达的组合物和方法

    公开(公告)号:US07994309B2

    公开(公告)日:2011-08-09

    申请号:US12817009

    申请日:2010-06-16

    IPC分类号: C07H21/04

    摘要: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a complementary RNA strand having a complementary region that is substantially complementary to a portion of the mutant gene, and which is partially complementary to the corresponding wild-type gene. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.

    摘要翻译: 本发明涉及用于抑制突变基因表达的双链核糖核酸(dsRNA),其包含互补RNA链,其具有与突变基因的一部分基本上互补的互补区,并且其部分互补于 相应的野生型基因。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达,以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法,以及用于治疗由靶基因表达引起的疾病的方法。

    Compositions and methods for inhibiting expression of a mutant gene
    17.
    发明授权
    Compositions and methods for inhibiting expression of a mutant gene 有权
    用于抑制突变基因表达的组合物和方法

    公开(公告)号:US07763590B2

    公开(公告)日:2010-07-27

    申请号:US10384463

    申请日:2003-03-07

    IPC分类号: A61K48/00

    摘要: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a mutant gene, comprising a complementary RNA strand having a complementary region that is substantially complementary to a portion of the mutant gene, and which is partially complementary to the corresponding wild-type gene. The invention further relates to a pharmaceutical composition comprising the dsRNA and a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for inhibiting the expression of a target mutant gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target mutant gene, as well as methods for treating diseases caused by the expression of the target gene.

    摘要翻译: 本发明涉及用于抑制突变基因表达的双链核糖核酸(dsRNA),其包含互补RNA链,其具有与突变基因的一部分基本上互补的互补区,并且其部分互补于 相应的野生型基因。 本发明还涉及包含dsRNA和药学上可接受的载体的药物组合物。 药物组合物可用于抑制靶突变基因的表达,以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶突变基因表达的方法,以及用于治疗由靶基因表达引起的疾病的方法。