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    DOUBLE-STRANDED RNA (dsRNA) AND METHOD OF USE FOR INHIBITING EXPRESSION OF A FUSION GENE
    4.
    发明申请
    DOUBLE-STRANDED RNA (dsRNA) AND METHOD OF USE FOR INHIBITING EXPRESSION OF A FUSION GENE 审中-公开
    双链RNA（dsRNA）和用于抑制融合基因表达的方法

    公开(公告)号：US20110065777A1

    公开(公告)日：2011-03-17

    申请号：US12912616

    申请日：2010-10-26

    申请人： Olaf Heidenreich ,  Hans-Peter Vornlocher ,  Roland Kreutzer ,  Stefan Limmer

    发明人： Olaf Heidenreich ,  Hans-Peter Vornlocher ,  Roland Kreutzer ,  Stefan Limmer

    IPC分类号： A61K31/713 ,  C07H21/02 ,  A61P35/00 ,  C12N5/071 ,  C12N5/078

    CPC分类号： C12N15/1135 ,  A61K38/00 ,  C12N2310/14 ,  C12N2310/3183 ,  C12N2310/53

    摘要： Specific inhibition of expression of a fusion gene in mammals occurs using a short, double-stranded ribonucleic acid molecule (dsRNA). The dsRNA comprises two separate non-linked RNA strands, an 51 strand and a complementary strand. The strands are 20 to 23 nucleotides in length, and the 51 strand is complementary to the fusion junction of the AML-1/MTG-8 fusion gene. The dsRNA also comprises at least 3 nucleotides on each side of the fusion junction. The dsRNA can be introduced into and maintained in a mammalian cell under conditions and for a time sufficient to obtain degradation of mRNA of the fusion gene to inhibit expression of the fusion gene. The dsRNAs and methods described are useful for treating diseases caused by chromosomal aberrations, particularly malignant diseases such as lymphoma and leukemia.

    摘要翻译： 使用短的双链核糖核酸分子（dsRNA）发生融合基因在哺乳动物中的表达的特异性抑制。 dsRNA包含两个单独的非连接的RNA链，51链和互补链。 链长为20至23个核苷酸，51链与AML-1 / MTG-8融合基因的融合连接互补。 dsRNA还在融合连接的每一侧上包含至少3个核苷酸。 可以在足以获得融合基因mRNA降解以抑制融合基因表达的条件下和时间内将dsRNA引入哺乳动物细胞并保持在哺乳动物细胞中。 描述的dsRNA和方法可用于治疗由染色体畸变引起的疾病，特别是恶性疾病如淋巴瘤和白血病。

    COMPOSITIONS AND METHODS FOR INHIBITING VIRAL REPLICATION
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR INHIBITING VIRAL REPLICATION 有权
    用于抑制病毒复制的组合物和方法

    公开(公告)号：US20080194512A1

    公开(公告)日：2008-08-14

    申请号：US11959936

    申请日：2007-12-19

    申请人： Matthias John ,  Stefan Limmer ,  Hans-Peter Vornlocher ,  Roland Kreutzer

    发明人： Matthias John ,  Stefan Limmer ,  Hans-Peter Vornlocher ,  Roland Kreutzer

    IPC分类号： A61K31/70 ,  C07H21/04

    CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.

    摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。

    Compositions and methods for inhibiting viral replication
    7.
    发明授权
    Compositions and methods for inhibiting viral replication 有权
    用于抑制病毒复制的组合物和方法

    公开(公告)号：US07348314B2

    公开(公告)日：2008-03-25

    申请号：US10384512

    申请日：2003-03-07

    申请人： Matthias John ,  Stefan Limmer ,  Hans-Peter Vornlocher ,  Roland Kreutzer

    发明人： Matthias John ,  Stefan Limmer ,  Hans-Peter Vornlocher ,  Roland Kreutzer

    IPC分类号： A61K31/70 ,  C07H21/04 ,  C07H21/00

    CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.

    摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。

    Compositions and methods for inhibiting viral replication
    10.
    发明授权
    Compositions and methods for inhibiting viral replication 有权
    用于抑制病毒复制的组合物和方法

    公开(公告)号：US08273868B2

    公开(公告)日：2012-09-25

    申请号：US12631689

    申请日：2009-12-04

    申请人： Matthias John ,  Stefan Limmer ,  Hans-Peter Vornlocher ,  Roland Kreutzer

    发明人： Matthias John ,  Stefan Limmer ,  Hans-Peter Vornlocher ,  Roland Kreutzer

    IPC分类号： C07H21/04 ,  A61K31/70

    CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.

    摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。