摘要:
The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g., autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
摘要:
The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g., autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.
摘要:
The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods herein are further provided.
摘要:
The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods herein are further provided.
摘要:
Systems and methods are provided for dispensing compositions comprising sols, sol-forming compounds, or highly viscous compositions into porous substrates. In some embodiments, the porous substrates are elements of transdermal delivery devices. In some embodiments, the highly viscous compositions comprise alkylcellulose ethers, or derivatives thereof, in particular, hydroxypropyl cellulose. Such may be useful in continuous web-based manufacturing processes.
摘要:
Systems, devices, and methods for transdermal delivery of one or more therapeutic active agents to a biological interface. An iontophoretic drug delivery system is provided for transdermal delivery of one or more therapeutic active agents to a biological interface of a subject. The iontophoretic drug delivery system includes at least one active agent reservoir. The one or more active agent reservoirs are loadable with a vehicle for transporting, delivering, encapsulating, and/or carrying the one or more active agents
摘要:
A method and apparatus for separating target particles from a mixture of target and non-target particles. The apparatus includes a vessel having an inlet through which the mixture may be introduced and an outlet through which the fluid may exit, at least a portion of which is pliable; a bed of binding material disposed within the vessel, the binding material attracting the target particles such that the target particles may become bound thereto and being porous enough to allow the non-target particles to pass therethrough; and a screen disposed below the binding material for retaining the binding material in place. The pliable portion of the vessel permits the user to separate the target particles from the binding material by merely squeezing the pliable portion in such a manner as to cause relative movement in the binding material, thereby creating the necessary degree of agitation to cause the target particles to become dislodged from the binding material. The deformation of the pliable vessel can be accomplished by either the user physically squeezing the vessel with his/her hand or using an external apparatus that applies the necessary force to the vessel.