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公开(公告)号：US20110092679A1
公开(公告)日：2011-04-21
申请号：US12765844
申请日：2010-04-22
Applicant: Ronald M. Cook , Matt Lyttle , Daren Dick
Inventor： Ronald M. Cook , Matt Lyttle , Daren Dick
IPC: C07C245/08 , C07K17/02
CPC classification number: C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
Abstract translation: 本发明提供了一种称为黑洞猝灭剂（“BHQ”）的暗猝灭剂，它们是激发态能的有效猝灭剂，但它们本身基本上是非荧光的。 还提供了使用BHQ，并入BHQ的探针和使用探针的方法的方法。
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公开(公告)号：US20100021922A1
公开(公告)日：2010-01-28
申请号：US12546927
申请日：2009-08-25
Applicant: Ronald M. Cook , Matt Lyttle , Daren Dick
Inventor： Ronald M. Cook , Matt Lyttle , Daren Dick
IPC: C12Q1/68
CPC classification number: C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
Abstract translation: 本发明提供了一种称为黑洞猝灭剂（“BHQ”）的暗猝灭剂，它们是激发态能的有效猝灭剂，但它们本身基本上是非荧光的。 还提供了使用BHQ，并入BHQ的探针和使用探针的方法的方法。
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公开(公告)号：US07635762B2
公开(公告)日：2009-12-22
申请号：US10690806
申请日：2003-10-21
Applicant: Ronald M. Cook , Matt Lyttle , Mary Katherine Johansson
Inventor： Ronald M. Cook , Matt Lyttle , Mary Katherine Johansson
CPC classification number: C07F15/0053 , C07B2200/11 , C09B56/00 , C09B57/10 , Y10T436/143333
Abstract: The present invention provides luminescent metal ion complexes for use in a wide range of biological and chemical studies. The luminescent metal ion complexes of the invention comprise a metal ion chelating component covalently bound to a carrier molecule. Also provided are methods of making and using the luminescent metal ion complexes.
Abstract translation: 本发明提供用于广泛的生物和化学研究的发光金属离子络合物。 本发明的发光金属离子络合物包含与载体分子共价结合的金属离子螯合组分。 还提供了制造和使用发光金属离子络合物的方法。
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公开(公告)号：US07109312B2
公开(公告)日：2006-09-19
申请号：US11192705
申请日：2005-07-29
Applicant: Ronald M. Cook , Matt Lyttle , Daren Dick
Inventor： Ronald M. Cook , Matt Lyttle , Daren Dick
IPC: C07C245/00 , C07H21/04 , C07H19/04
CPC classification number: C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
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公开(公告)号：US07019129B1
公开(公告)日：2006-03-28
申请号：US09567863
申请日：2000-05-09
Applicant: Ronald M. Cook , Matt Lyttle , Daren Dick
Inventor： Ronald M. Cook , Matt Lyttle , Daren Dick
CPC classification number: C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
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Patent Agency Ranking
公开(公告)号：US20060035262A1
公开(公告)日：2006-02-16
申请号：US11226852
申请日：2005-09-13
Applicant: Ronald Cook , Matt Lyttle , Daren Dick
Inventor： Ronald Cook , Matt Lyttle , Daren Dick
CPC classification number: C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
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公开(公告)号：US09228225B2
公开(公告)日：2016-01-05
申请号：US12941931
申请日：2010-11-08
Applicant: Mark Reddington , Matt Lyttle
Inventor： Mark Reddington , Matt Lyttle
IPC: A61B10/00 , A61B8/00 , A61B5/00 , C12Q1/37 , C07D311/90 , C07D405/14 , C07F9/655 , C07F9/6558 , G01N33/58
CPC classification number: C12Q1/37 , C07D311/90 , C07D405/14 , C07F9/65522 , C07F9/65586 , C09B11/24 , G01N33/582
Abstract: The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and using the dyes and their conjugates and kits including the dyes and their conjugates.
Abstract translation: 本发明提供了一类新的呫吨染料，其中一些被官能化以允许它们与感兴趣的缀合配偶体偶联，例如。 生物分子，药物，毒素等。 还提供了染料的缀合物，制备和使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。
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公开(公告)号：US20070154898A1
公开(公告)日：2007-07-05
申请号：US11437991
申请日：2006-05-19
Applicant: Ronald Cook , Matt Lyttle , Daren Dick
Inventor： Ronald Cook , Matt Lyttle , Daren Dick
CPC classification number: C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
Abstract translation: 本发明提供了一种称为黑洞猝灭剂（“BHQ”）的暗猝灭剂，它们是激发态能的有效猝灭剂，但它们本身基本上是非荧光的。 还提供了使用BHQ，并入BHQ的探针和使用探针的方法的方法。
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公开(公告)号：US20050170363A1
公开(公告)日：2005-08-04
申请号：US10824175
申请日：2004-04-13
Applicant: Mark Reddington , Matt Lyttle
Inventor： Mark Reddington , Matt Lyttle
IPC: C07D311/90 , C07D405/14 , C07D491/14 , C07D491/22 , C07F9/655 , C07F9/6558 , C07K14/47 , C12Q1/37 , C12Q1/68 , G01N33/53 , G01N33/58
CPC classification number: C12Q1/37 , C07D311/90 , C07D405/14 , C07F9/65522 , C07F9/65586 , C09B11/24 , G01N33/582
Abstract: The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and using the dyes and their conjugates and kits including the dyes and their conjugates.
Abstract translation: 本发明提供了一类新的呫吨染料，其中一些被官能化以允许它们与感兴趣的缀合配偶体偶联，例如。 生物分子，药物，毒素等。 还提供了染料的缀合物，制备和使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。
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公开(公告)号：US20080214811A1
公开(公告)日：2008-09-04
申请号：US12036926
申请日：2008-02-25
Applicant: Mark Reddington , Matt Lyttle
Inventor： Mark Reddington , Matt Lyttle
IPC: C07D311/82 , C07D311/88 , C07D405/02 , C07D405/10 , C07D405/14 , C07F9/06
CPC classification number: C12Q1/37 , C07D311/90 , C07D405/14 , C07F9/65522 , C07F9/65586 , C09B11/24 , G01N33/582
Abstract: The invention provides a novel class of xanthene dyes, some of which are functionalized to allow their coupling to conjugation partners of interest, e.g. biomolecules, drugs, toxins and the like. Also provided are conjugates of the dyes, methods of preparing and using the dyes and their conjugates and kits including the dyes and their conjugates.
Abstract translation: 本发明提供了一类新的呫吨染料，其中一些被官能化以允许它们与感兴趣的缀合配偶体偶联，例如。 生物分子，药物，毒素等。 还提供了染料的缀合物，制备和使用染料及其缀合物的方法和试剂盒，包括染料及其缀合物。
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