公开(公告)号：US20100063079A1

公开(公告)日：2010-03-11

申请号：US12508934

申请日：2009-07-24

Applicant: MARK EBDEN ,  PREMJI MEGHANI ,  COLIN BENNION ,  ANTHONY RONALD COOK ,  ROGER VICTOR BONNERT

Inventor： MARK EBDEN ,  PREMJI MEGHANI ,  COLIN BENNION ,  ANTHONY RONALD COOK ,  ROGER VICTOR BONNERT

IPC: A61K31/505 ,  C07D239/02

CPC classification number: C07D239/48 ,  C07D239/69 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid arthritis, psoriasis or cancer.

Abstract translation: 用于治疗哮喘，过敏性鼻炎，COPD，炎症性肠病，肠易激综合征，骨关节炎，骨质疏松症，类风湿性关节炎，牛皮癣或癌症的式（I）化合物，其药学上可接受的盐，溶剂合物或体内可水解的酯。

公开(公告)号：US07482355B2

公开(公告)日：2009-01-27

申请号：US10525495

申请日：2003-08-20

Applicant: Mark Richard Ebden ,  Premji Meghani ,  Anthony Ronald Cook ,  John Steele ,  Lal Lashkar Singh Cheema

Inventor： Mark Richard Ebden ,  Premji Meghani ,  Anthony Ronald Cook ,  John Steele ,  Lal Lashkar Singh Cheema

IPC: C07D239/56 ,  A61K31/513

CPC classification number: C07D239/56 ,  C07D239/60 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Compounds of formula (1), pharmaceutically acceptable salts, solvates and in vivo hydrolysable esters thereof, have activity as pharmaceuticals, in particular as modulators of chemokine receptor (especially CXCR2) activity, and may be in the treatment (therapeutic or prophylactic) of conditions/diseases in human and non-human animals which are exacerbated or caused by excessive or unregulated production of chemokines.

Abstract translation: 式（1）的化合物，其药学上可接受的盐，溶剂化物和体内可水解的酯具有作为药物的活性，特别是作为趋化因子受体（特别是CXCR2）活性的调节剂，并且可以处于（治疗或预防）条件 /人类和非人类动物中的疾病，其由于趋化因子的过量或不受调节的产生而加剧或引起。

公开(公告)号：US20060035262A1

公开(公告)日：2006-02-16

申请号：US11226852

申请日：2005-09-13

Applicant: Ronald Cook ,  Matt Lyttle ,  Daren Dick

Inventor： Ronald Cook ,  Matt Lyttle ,  Daren Dick

IPC: C12Q1/68 ,  C07H21/04

CPC classification number: C07H21/00 ,  C07B2200/11 ,  C07C245/08 ,  C07D241/46 ,  C07F9/091 ,  C07F9/2408 ,  C09B31/043 ,  C09B56/00 ,  C09B56/12 ,  C12Q1/6818 ,  C40B40/00 ,  G01N33/542 ,  G01N33/582

Abstract: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

公开(公告)号：US06741134B2

公开(公告)日：2004-05-25

申请号：US10151433

申请日：2002-05-21

Applicant: Clifford Neil Didcock ,  Charles Ronald Cook ,  Michael Geoffrey Andrew Wilson ,  Charles Graeme Ritchie

Inventor： Clifford Neil Didcock ,  Charles Ronald Cook ,  Michael Geoffrey Andrew Wilson ,  Charles Graeme Ritchie

IPC: H03F130

CPC classification number: H03F3/3432 ,  G05F3/265 ,  H03F1/302

Abstract: A DC feedback control circuit for compensating for a DC voltage level shift in a transimpedance amplifier circuit having a transistor as a high speed switching device. The DC feedback control circuit includes a filter for determining a DC voltage level at an output of the amplifier circuit and a differential pair of transistors for comparing the DC voltage level with a reference voltage. A pair of current mirrors mirror a current dependent on the comparison of the DC voltage level with the reference voltage and apply the mirrored current to an emitter of the transistor so as to maintain a substantially constant bias current through the switching transistor.

Abstract translation: 一种DC反馈控制电路，用于补偿具有作为高速开关器件的晶体管的跨阻放大器电路中的直流电压电平移位。 DC反馈控制电路包括用于确定放大器电路的输出处的DC电压电平的滤波器和用于将DC电压电平与参考电压进行比较的差分对晶体管。 一对电流镜根据直流电压电平与参考电压的比较来反射电流，并将镜像电流施加到晶体管的发射极，以保持通过开关晶体管的基本恒定的偏置电流。

公开(公告)号：US4587925A

公开(公告)日：1986-05-13

申请号：US664251

申请日：1984-10-24

Applicant: Ronald Cook

Inventor： Ronald Cook

IPC: B05C1/02

CPC classification number: B05C1/027 ,  B05C1/022

Abstract: A continuous adhesive applicator for applying adhesive, sealant, or the like to cans as they travel along an automated processing line. The apparatus moves the cans through the station area while holding the cans in a selected orientation, rotates the cans as they move through the station, and applies adhesive or the like to a selected portion of each can as it moves through the station. Restraining means, which are cycled for repetitive movement through the station along the path of travel of the line of cans, capture the cans and move them through the station while holding them in the selected orientation.

Abstract translation: 一种连续的粘合剂涂布器，用于当它们沿着自动化处理线行进时，将粘合剂，密封剂等用于罐头。 该装置将罐移动通过车站区域，同时将罐头保持在选定的方向，当罐子移动通过车站时旋转罐，并且当罐子移动通过车站时，将胶粘剂等施加到每个罐的选定部分。 沿着罐头行进路线重复移动通过车站的限制装置捕获罐并将它们移动通过车站，同时将它们保持在所选择的方向。

公开(公告)号：US08524715B2

公开(公告)日：2013-09-03

申请号：US11719832

申请日：2005-11-22

Applicant: Roger Victor Bonnert ,  Lilian Alcaraz ,  Rukhsana Tasneem Mohammed ,  Anthony Ronald Cook ,  Stephen Thom ,  Timothy Jon Luker

Inventor： Roger Victor Bonnert ,  Lilian Alcaraz ,  Rukhsana Tasneem Mohammed ,  Anthony Ronald Cook ,  Stephen Thom ,  Timothy Jon Luker

IPC: A61K31/497 ,  C07D295/00

CPC classification number: C07D333/24 ,  C07D207/48 ,  C07D213/34 ,  C07D213/56 ,  C07D241/08

Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

Abstract translation: 本发明涉及取代的苯氧基乙酸作为治疗呼吸系统疾病的有用的药物化合物，含有它们的药物组合物及其制备方法。

公开(公告)号：US20100056508A1

公开(公告)日：2010-03-04

申请号：US12519591

申请日：2007-12-19

Applicant: Lilian Alcaraz ,  Roger Victor Bonnert ,  Stephen Connolly ,  Anthony Ronald Cook ,  Adrian Fisher ,  Alexander Humphries ,  Piotr Raubo

Inventor： Lilian Alcaraz ,  Roger Victor Bonnert ,  Stephen Connolly ,  Anthony Ronald Cook ,  Adrian Fisher ,  Alexander Humphries ,  Piotr Raubo

IPC: A61K31/536 ,  C07D265/36 ,  A61K31/16 ,  C07C237/00

CPC classification number: C07D265/36 ,  C07C233/43 ,  C07C2601/14 ,  C07D209/34 ,  C07D215/26 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention provides compounds of formula (I), wherein k, Ar, R2, R3, R4, R5, R4′, R5′, R6, R7, A, D, m and E are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract translation: 本发明提供式（I）化合物，其中k，Ar，R2，R3，R4，R5，R4'，R5'，R6，R7，A，D，m和E如说明书中所定义， 其制剂，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：US07582644B2

公开(公告)日：2009-09-01

申请号：US10522871

申请日：2003-07-23

Applicant: Mark Ebden ,  Premji Meghani ,  Colin Bennion ,  Anthony Ronald Cook ,  Roger Victor Bonnert

Inventor： Mark Ebden ,  Premji Meghani ,  Colin Bennion ,  Anthony Ronald Cook ,  Roger Victor Bonnert

IPC: C07D239/46 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D405/12 ,  C07D405/14 ,  A61K31/505 ,  A61K31/506 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P35/00

CPC classification number: C07D239/48 ,  C07D239/69 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: A compound of formula (I), pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof for the treatment of asthma, allergic rhinitis, COPD, inflammatory bowel disease, irritable bowel syndrome, osteoarthritis, osteoporosis, rheumatoid arthritis, psoriasis or cancer.

Abstract translation: 用于治疗哮喘，过敏性鼻炎，COPD，炎症性肠病，肠易激综合征，骨关节炎，骨质疏松症，类风湿性关节炎，牛皮癣或癌症的式（I）化合物，其药学上可接受的盐，溶剂合物或体内可水解的酯。

公开(公告)号：US20070059752A1

公开(公告)日：2007-03-15

申请号：US11520152

申请日：2006-09-13

Applicant: Ronald Cook

Inventor： Ronald Cook

IPC: C12Q1/68 ,  C07J17/00 ,  C07H21/04 ,  C12P19/34

CPC classification number: C07H21/04 ,  C07H21/00 ,  C07H21/02 ,  C07J51/00 ,  C12Q1/6816 ,  C12Q1/6818 ,  C12Q2525/125 ,  C12Q2525/191 ,  C12Q2565/1015

Abstract: The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties.

公开(公告)号：US20050176851A1

公开(公告)日：2005-08-11

申请号：US10412737

申请日：2003-04-11

Applicant: Ronald Cook

Inventor： Ronald Cook

IPC: B32B5/16 ,  B32B15/04 ,  C08K9/10 ,  C09K3/00

CPC classification number: C08K9/04 ,  B01J2/30 ,  B82Y30/00 ,  C01P2004/64 ,  C08K3/22 ,  C08K3/346 ,  C09C1/24 ,  C09C1/407 ,  C09D5/082 ,  C09D163/00 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2998 ,  Y10T428/31678 ,  C08L2666/54

Abstract: A new class of releasable corrosion inhibiting materials for protective coatings, methods of making the same, methods of using the same, and coatings containing the same are provided. The materials comprise one or more corrosion inhibitors that are chemically anchored to the surface of a particle having an aluminum oxyhydroxide surface through a carboxylate bond. The carboxylate/aluminum-oxyhydroxide-surface bond breaks under corrosion-causing conditions (for example the presence of high levels of hydroxide ions generated by the cathodic oxygen reduction reaction on metals such as iron and aluminum) thereby allowing the corrosion inhibitors to detach from the particle surface when corrosion is present.

Abstract translation: 提供了一类用于保护涂层的可释放的防腐蚀材料，其制备方法，使用方法和含有它们的涂层。 这些材料包括一种或多种腐蚀抑制剂，其通过羧酸盐键化学锚定到具有羟基氧化铝表面的颗粒的表面。 羧酸盐/羟基氧化铝 - 表面键在腐蚀条件下（例如，通过阴极氧还原反应产生的高水平氢氧根离子存在于金属和铝等金属上），从而使腐蚀抑制剂从 存在腐蚀时的颗粒表面。