公开(公告)号：US20080098795A1

公开(公告)日：2008-05-01

申请号：US11924701

申请日：2007-10-26

申请人： Joseph Orr

发明人： Joseph Orr

IPC分类号： G01N7/00 ,  G01N33/497

CPC分类号： G01N33/0006 ,  A61M16/024 ,  A61M16/12 ,  A61M2016/0027 ,  A61M2016/1025 ,  A61M2016/1035 ,  A61M2205/50 ,  A61M2205/70 ,  A61M2205/702

摘要： One aspect of the invention relates to a system adapted to calibrate a determination of information related to one or more gaseous analytes in a body of gas being delivered to an objective by a gas source. In one embodiment the system comprises a partial pressure sensor, a total pressure monitor, a partial pressure module, and a calibration module. The partial pressure sensor generates an output signal related to the partial pressure of the one or more gaseous analytes in the body of gas. The total pressure monitor determines the total pressure of the body of gas. The partial pressure module determines the partial pressure of the one or more gaseous analytes in the body of gas according to a partial pressure function, wherein the partial pressure function describes the partial pressure of the one or more gaseous analytes in the body of gas as a function of the output signal generated by the partial pressure sensor. The calibration module that calibrates the partial pressure module by determining the partial pressure function.

摘要翻译： 本发明的一个方面涉及一种系统，其适于校准与通过气体源传送到物镜的气体中的一种或多种气态分析物相关的信息的确定。 在一个实施例中，系统包括分压传感器，总压力监测器，分压模块和校准模块。 分压传感器产生与气体中的一种或多种气态分析物的分压有关的输出信号。 总压力监测器确定气体的总压力。 分压模块根据分压函数确定气体体内的一种或多种气体分析物的分压，其中分压功能描述气体中一种或多种气态分析物的分压作为 由分压传感器产生的输出信号的功能。 校准模块，通过确定分压功能校准分压模块。

公开(公告)号：US20050177055A1

公开(公告)日：2005-08-11

申请号：US11102072

申请日：2005-04-08

申请人： Kai Kuck ,  Joseph Orr ,  Lara Brewer

发明人： Kai Kuck ,  Joseph Orr ,  Lara Brewer

IPC分类号： A61B5/026 ,  A61B5/08 ,  A61B5/083 ,  A61B5/087 ,  G01N1/22 ,  A61M15/00 ,  A61M16/10

CPC分类号： A61B5/0836 ,  A61B5/029 ,  G01N33/497 ,  G01N2001/2244

摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

摘要翻译： 用于估计个体呼吸道二氧化碳储存体积的方法包括确定二氧化碳储存容积，其中二氧化碳消除的相应信号与个体血液中二氧化碳含量的指标被优化之间的相关性。 包括个人呼吸道或肺的模型的二氧化碳储存量的估算可以用作改善二氧化碳消除和二氧化碳含量信号中的一种或两种的准确性的转化 。 还公开了转换或滤波算法，以及可以使用方法和算法的系统。 方法，算法和系统可用于精确地和非侵入性地确定个体的肺毛细血管血流量和心输出量中的一个或两个。

公开(公告)号：US20070225612A1

公开(公告)日：2007-09-27

申请号：US11701187

申请日：2007-02-01

申请人： Leslie Mace ,  Joseph Orr ,  David Rich ,  Michael Jaffe ,  Jason Alderete

发明人： Leslie Mace ,  Joseph Orr ,  David Rich ,  Michael Jaffe ,  Jason Alderete

IPC分类号： A61B5/083

CPC分类号： A61B5/083 ,  A61B5/087 ,  A61B5/097

摘要： A system for measuring a metabolic parameter. The system includes an integrated airway adapter capable of monitoring any combination of respiratory flow, O2 concentration, and concentrations of one or more of CO2, N2O, and an anesthetic agent in real time, breath by breath. Respiratory flow may be monitored with differential pressure flow meters under diverse inlet conditions through improved sensor configurations which minimize phase lag and dead space within the airway. Molecular oxygen concentration may be monitored by way of luminescence quenching techniques. Infrared absorption techniques may be used to monitor one or more of CO2, N2O, and anesthetic agents.

摘要翻译： 用于测量代谢参数的系统。 该系统包括能够监测呼吸流量O 2浓度的任何组合以及CO 2 2 N 2 N 2的一种或多种的浓度的集成气道适配器， / SUB> O，麻醉剂实时呼吸。 可以通过改进的传感器配置在不同入口条件下通过差压流量计监测呼吸流量，从而最小化气道内的相位滞后和死区。 可以通过发光淬灭技术监测分子氧浓度。 红外吸收技术可用于监测一种或多种CO 2，N 2 O和麻醉剂。

公开(公告)号：US20060253038A1

公开(公告)日：2006-11-09

申请号：US11483460

申请日：2006-07-10

申请人： Kai Kuck ,  Joseph Orr ,  Lara Brewer

发明人： Kai Kuck ,  Joseph Orr ,  Lara Brewer

IPC分类号： A61B5/02 ,  G01N33/497 ,  A61B5/08

CPC分类号： A61B5/0836 ,  A61B5/029 ,  G01N33/497 ,  G01N2001/2244

摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

公开(公告)号：US20060129055A1

公开(公告)日：2006-06-15

申请号：US11347611

申请日：2006-02-03

申请人： Joseph Orr ,  Kai Kuck

发明人： Joseph Orr ,  Kai Kuck

IPC分类号： A61B5/08 ,  G01N33/497 ,  G01N1/22

CPC分类号： A61B5/0836 ,  A61B5/029 ,  G01N33/497 ,  G01N2001/2244

摘要： Methods for noninvasively determining a pulmonary capillary blood flow or a cardiac output of a subject include determining data of the amount of gas exchanged between blood and gas in lungs of the subject, as well as data of an indicator of the content of the gas in blood of the subject. Such a determination may be made during two or more different states of ventilation. A geometric relationship is identified between data points, with any data points outlying the geometric relationship being disregarded. The remaining data points may be used to estimate or calculate a measure of pulmonary capillary blood flow or cardiac output. Systems that include elements that are configured to effect such methods are also disclosed.

摘要翻译： 用于非侵入性地确定受试者的肺毛细血管血流量或心输出量的方法包括确定受试者肺中血液和气体之间交换的气体量的数据，以及血液中气体含量指标的数据 的主题。 这种确定可以在两个或更多个不同的通气状态下进行。 在数据点之间识别出几何关系，并且忽略几何关系的任何数据点。 剩余的数据点可用于估计或计算肺毛细血管血流量或心输出量的量度。 还公开了包括被配置为实现这些方法的元素的系统。

公开(公告)号：US20050124907A1

公开(公告)日：2005-06-09

申请号：US10973815

申请日：2004-10-25

申请人： Kai Kuck ,  Joseph Orr ,  Lara Brewer

发明人： Kai Kuck ,  Joseph Orr ,  Lara Brewer

IPC分类号： A61B5/083 ,  A61B5/091 ,  G01N1/22 ,  A61B5/08 ,  B32B5/02 ,  G01N31/00 ,  G01N33/497

CPC分类号： A61B5/0836 ,  A61B5/091

摘要： Methods for noninvasively measuring, or estimating, functional residual capacity or effective lung volume include obtaining carbon dioxide and flow measurements at or near the mouth of a subject. Such measurements are obtained during baseline breathing and during and shortly after inducement of a change in the subject's effective ventilation. The obtained measurements are evaluated to determine the amount of time required for exhaled carbon dioxide levels to return to normal—effectively an evaluation of carbon dioxide “washout” from the subject's lungs. Conversely, carbon dioxide and flow measurements may be evaluated to determine the amount of time it takes carbon dioxide to “wash in,” or reach peak levels within, the lungs of the subject following the change in the subject's effective ventilation. Apparatus for effective such methods are also disclosed.

摘要翻译： 用于非侵入性测量或估计功能残余容量或有效肺体积的方法包括在受试者的嘴部或附近获得二氧化碳和流量测量。 在基线呼吸期间和受试者的有效通气改变之后及之后不久，获得这些测量。 评估所获得的测量值，以确定呼出二氧化碳水平回复正常有效地评估受试者肺部二氧化碳“冲洗”所需的时间。 相反，可以评估二氧化碳和流量测量，以确定在受试者有效通气改变之后二氧化碳“洗涤”所需的时间，或达到受试者肺部内的峰值水平。 还公开了用于有效的这种方法的装置。

公开(公告)号：US5579778A

公开(公告)日：1996-12-03

申请号：US294938

申请日：1994-08-23

申请人： Phillip D. Baker ,  Joseph Orr ,  Dwayne R. Westenskow ,  Royce W. Johnson

发明人： Phillip D. Baker ,  Joseph Orr ,  Dwayne R. Westenskow ,  Royce W. Johnson

IPC分类号： A61B5/028 ,  G06F17/00 ,  A61B5/00

CPC分类号： A61B5/028 ,  A61B5/7267 ,  Y10S128/925

摘要： A method and device for indirect, quantitative estimation of cardiac output utilizing invasive, indirect techniques. The method of practice includes (i) generating a sequence of signals which are quantitatively dependent upon cardiac output, (ii) transmitting and processing the signals within a computer system and associated neural network capable of generating a single output signal for the combined input signals, (iii) directly determining an actual value for the parameter concurrent with the invasive generation of signals of the previous steps, (iv) applying weighting factors within the neural network at interconnecting nodes to force the output signal of the neural network to match the known value of the parameter as determined invasively, (v) recording the input signals, weighting factors and known value as training data within memory of the computer, and (vi) repeating the previous steps to develop sufficient training data to enable the neural network to accurately estimate parameter value upon future receipt of on-line input signals. Procedures are also described for preclassification of signals and artifact rejection. Following training of the neural network, further direct measurement is unnecessary and the system is ready for diagnostic application and invasive estimation of parameter values.

摘要翻译： 一种利用侵入性间接技术间接，定量估计心输出量的方法和装置。 实践方法包括（i）产生定量依赖于心输出量的信号序列，（ii）在计算机系统内发送和处理能够为组合的输入信号产生单个输出信号的相关神经网络的信号， （iii）直接确定与先前步骤的信号的入侵生成同时参数的实际值，（iv）在互连节点处在神经网络内应用加权因子以迫使神经网络的输出信号与已知值相匹配 （v）将输入信号，加权因子和已知值记录在计算机的存储器内的训练数据，以及（vi）重复先前的步骤以开发足够的训练数据，以使得神经网络能够准确估计 在将来接收在线输入信号时的参数值。 还描述了信号的预分类和伪像抑制的程序。 在神经网络训练之后，进一步的直接测量是不必要的，系统已准备好进行诊断应用和参数值的侵入性估计。

公开(公告)号：USD691717S1

公开(公告)日：2013-10-15

申请号：US29401540

申请日：2011-09-12

申请人： Bruce S. McLean ,  Joseph Orr ,  Mark Muszynski

设计人： Bruce S. McLean ,  Joseph Orr ,  Mark Muszynski

公开(公告)号：US20080041385A1

公开(公告)日：2008-02-21

申请号：US11843994

申请日：2007-08-23

申请人： Joseph Orr ,  Derek Sakata ,  Dwayne Westenskow

发明人： Joseph Orr ,  Derek Sakata ,  Dwayne Westenskow

IPC分类号： A61M16/01

CPC分类号： A61M16/009 ,  A61M16/0045 ,  A61M16/0093 ,  A61M16/0833 ,  A61M16/085 ,  A61M16/0891 ,  A61M16/105 ,  A61M16/1055 ,  A61M16/106 ,  A61M16/22

摘要： An apparatus for reversing inhaled anesthesia, which is configured to be positioned along a breathing circuit or anesthesia delivery circuit, includes a filter for removing one or more anesthetic agents from gases passing therethrough, as well as a component for elevating CO2 levels in gases that are to be inhaled by an individual. The apparatus is configured to be positioned between a Y-connector of the breathing circuit and the portion of the breathing circuit that interfaces with the individual. The CO2 level-elevating component facilitates an increase in the ventilation of the individual without resulting in a significant decrease in the individual's PaCO2 level and, thus, a decrease in the rate at which blood flows through the individual's brain. A method of reversing the effects of inhaled anesthesia includes increasing the rate of ventilation of an anesthetized individual while causing the individual to inhale gases with elevated amounts of CO2 and while filtering anesthetic agents from such gases.

摘要翻译： 用于反转吸入麻醉的装置，其被配置为沿着呼吸回路或麻醉输送回路定位，包括用于从通过其中的气体中去除一种或多种麻醉剂的过滤器，以及用于将CO 2升高的部件， / SUB>被个人吸入的气体中的水平。 该装置构造成位于呼吸回路的Y形连接器和与个体接触的部分呼吸回路之间。 CO 2升级组件有助于个体的通气量的增加，而不会导致个体的P <！ - SIPO

公开(公告)号：US20070261498A1

公开(公告)日：2007-11-15

申请号：US11705561

申请日：2007-02-12

申请人： Joseph Orr ,  Scott Kofoed ,  Kevin Durst

发明人： Joseph Orr ,  Scott Kofoed ,  Kevin Durst

IPC分类号： G01L7/00

CPC分类号： G01L13/00 ,  A61B5/087

摘要： A system for sensing respiratory pressure includes a portable pressure transducer configured to be carried by or proximate to a respiratory conduit, such as a breathing circuit or a nasal canula. The portable pressure transducer may removably couple with a pneumotach, in the form of an airway adapter, disposed along the respiratory conduit. The pneumotach may include two pressure ports positioned at opposite sides of an obstruction, which partially blocks flow through a primary conduit of the pneumotach. Corresponding sample conduits of the portable pressure transducer removably couple with the pressure ports. The pressure ports may have sealing elements which are configured to seal against piercing members of the sample conduits upon introduction of the piercing members therethrough. Upon removal of the piercing members, the sealing elements substantially reseal. Methods for using the system are also disclosed.