公开(公告)号：US20170165375A1

公开(公告)日：2017-06-15

申请号：US14781817

申请日：2014-04-02

Applicant: STC. UNM ,  SANDIA CORPORATION

Inventor： Carlee Erin Ashley ,  Eric C. Carnes ,  Terry Wu ,  Linda A. Felton ,  Darryl Y. Sasaki

IPC: A61K9/51 ,  A61K9/50 ,  A61K31/5383 ,  A61K31/65 ,  A61K31/546 ,  A61K31/635 ,  A61K31/505 ,  A61K9/00 ,  A61K9/127 ,  A61K31/7036

CPC classification number: A61K31/7036 ,  A61K9/0053 ,  A61K9/1271 ,  A61K9/1274 ,  A61K9/5021 ,  A61K9/5123 ,  A61K31/505 ,  A61K31/5383 ,  A61K31/546 ,  A61K31/635 ,  A61K31/65 ,  A61K47/52 ,  A61K47/60 ,  A61K47/62 ,  A61K47/68 ,  A61K47/6913 ,  A61K47/6917 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00 ,  Y02A50/404 ,  Y02A50/406 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

Abstract: The invention provides novel antibiotic protocells comprising mesoporous nanoparticles encapsulated within a lipid bi- or multilayer. The nanoparticles have pore sizes and surface chemistries that enable facile adsorption and intracellular presentation of antibiotics which are effective in the treatment of a wide variety of bacterial infections, including F. tularensis, B. pseudomallei and P. aeruginosa-related infections. Related pharmaceutical compositions and methods of treatment are also provided.

公开(公告)号：US20160090603A1

公开(公告)日：2016-03-31

申请号：US14871748

申请日：2015-09-30

Applicant: Sandia Corporation

Inventor： Eric Christopher Carnes ,  Anne Ruffing ,  Carlee Erin Ashley

IPC: C12N15/82

CPC classification number: A61K9/1274 ,  A61K9/501 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088 ,  A61K45/06 ,  A61K48/005 ,  A61K49/005 ,  C12N9/22 ,  C12N15/8206 ,  C12N2310/11 ,  C12N2310/20

Abstract: The present invention relates to a delivery platform that can be used to genetically modify a target in a plant or an alga. In one instance, polypeptides and/or polynucleotides can be delivered using silica delivery platforms, e.g., silica carriers or protocells. Such platforms can be employed to control gene activation and repression in the plant or alga.

Abstract translation: 本发明涉及可用于在植物或藻类中遗传修饰靶标的递送平台。 在一个实例中，多肽和/或多核苷酸可以使用二氧化硅递送平台例如二氧化硅载体或原细胞递送。 这样的平台可用于控制植物或藻类中的基因激活和抑制。

公开(公告)号：US20180110831A1

公开(公告)日：2018-04-26

申请号：US15557000

申请日：2016-03-09

Applicant: STC.UNM

Inventor： C. Jeffrey Brinker ,  Eric C. Carnes ,  Carlee Erin Ashley ,  Jacob Ongundi Agola ,  Kimberly Butler ,  Christophe Theron

IPC: A61K38/17 ,  A61K47/64 ,  A61K47/69 ,  A61K9/51 ,  C07K14/705

CPC classification number: A61K38/1774 ,  A61K9/127 ,  A61K9/5115 ,  A61K9/5123 ,  A61K47/6425 ,  A61K47/6911 ,  B82Y5/00 ,  C07K14/70546

Abstract: The present invention is directed to protocells, which have a core and a lipid bilayer surrounding the core, with at least one CD47 molecule or an active fragment thereof in or conjugated to the lipid bilayer. The CD47 present on the lipid bilayer allows the protocell to evade phagocytosis by macrophages, and can be conjugated to the lipid bilayer via a crosslinker. The protocell can be loaded with a diagnostic or therapeutic cargo, such as a polypeptide, a nucleic acid, or a drug. The protocell can also include a targeting species for targeted delivery of the cargo to a cell. The protocell can also include an endosomolytic peptide, which promotes endosomal escape after uptake by the targeted cell. The protocells with CD47 on the lipid bilayer provide better circulation after in vivo administration compared to protocells without CD47, and are therefore particularly useful as a cargo delivery vehicle.