公开(公告)号：US09862937B2

公开(公告)日：2018-01-09

申请号：US15515303

申请日：2015-10-07

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Denis Gribkov

IPC: C07C45/63 ,  C07C45/46 ,  C07C201/12 ,  C12N9/10 ,  C12P19/44

CPC classification number: C12N9/1085 ,  C07C45/63 ,  C07C201/08 ,  C12P19/44 ,  C07C205/45 ,  C07C49/80

Abstract: The invention relates to a process for the preparation of a compound of formula I (I), wherein R1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III), wherein R1 is hydrogen, fluoro or chloro; and b) reacting the compound of formula III with chlorine gas at temperature from 180° C. to 250° C. to the compound of formula I.

公开(公告)号：US09796646B2

公开(公告)日：2017-10-24

申请号：US14603857

申请日：2015-01-23

Applicant: Syngenta Participations AG

Inventor： Denis Gribkov ,  Bjorn Antelmann ,  Fanny Giordano ,  Harald Walter ,  Alain De Mesmaeker

IPC: C07C23/08 ,  C07C17/32 ,  C07C17/23 ,  C07C17/26 ,  C07C17/266 ,  C07C22/02 ,  C07C201/12 ,  C07C205/11 ,  C07C209/36 ,  C07C205/12

CPC classification number: C07C17/32 ,  C07C17/23 ,  C07C17/26 ,  C07C17/266 ,  C07C22/02 ,  C07C22/04 ,  C07C201/12 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C209/365 ,  C07C2601/10 ,  C07C2603/66 ,  C07C211/61

Abstract: The present invention relates to a novel process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCl3, wherein X is chloro or bromo, to a compound of formula II aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula II wherein X is chloro, b) reacting the compound of formula II with a base in the presence of an appropriate solvent to the compound of formula III c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.

公开(公告)号：US20150141712A1

公开(公告)日：2015-05-21

申请号：US14603857

申请日：2015-01-23

Applicant: Syngenta Participations AG ,  Syngenta Crop Protection LLC

Inventor： Denis Gribkov ,  Bjorn Antelmann ,  Fanny Giordano ,  Harald Walter ,  Alain De Mesmaeker

IPC: C07C17/32 ,  C07C205/12

CPC classification number: C07C17/32 ,  C07C17/23 ,  C07C17/26 ,  C07C17/266 ,  C07C22/02 ,  C07C22/04 ,  C07C201/12 ,  C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C209/365 ,  C07C2601/10 ,  C07C2603/66 ,  C07C211/61

Abstract: The present invention relates to a novel a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine which process comprises a) reacting cyclopentadiene in the presence of a radical initiator and CXCl3, wherein X is chloro or bromo, to a compound of formula I1, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula I1, wherein X is chloro, b) reacting the compound of formula I1 with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV, and d) hydrogenating the compound of formula IV in the presence of a metal catalyst.

Abstract translation: 本发明涉及一种制备9-二氯亚甲基-1,2,3,4-四氢-1,4-亚甲基 - 萘-5-基胺的新方法，该方法包括：a）使环戊二烯在 自由基引发剂和其中X是氯或溴的CXCl 3，或aa）在金属催化剂存在下将环戊二烯与CXCl 3（其中X是氯）与式II化合物反应，其中X是氯 b）使式I1化合物与碱在适当的溶剂存在下反应，得到式III化合物，c）并在1,2-脱氢-6-硝基苯存在下将式III化合物转化为 式Ⅳ化合物，和d）在金属催化剂存在下氢化式Ⅳ化合物。

公开(公告)号：US11365187B2

公开(公告)日：2022-06-21

申请号：US16638450

申请日：2018-08-09

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Denis Gribkov ,  Myriem El Qacemi ,  André Stoller ,  André Jeanguenat ,  Aurelien Bigot

IPC: C07D403/04 ,  A01N43/56 ,  C07D401/14

Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, molluse and nematode pests.

公开(公告)号：US11254643B2

公开(公告)日：2022-02-22

申请号：US16757303

申请日：2018-10-16

Applicant: Syngenta Participations AG

Inventor： Helmars Smits ,  Denis Gribkov ,  Edouard Godineau ,  Christopher Charles Scarborough ,  Alan James Robinson ,  Michael Christian Dieckmann

IPC: C07D403/12 ,  C07D237/14

Abstract: The present invention provides, inter alia, a process for producing a compound of Formula (I): wherein A1, R1, R2, R3, R4, R5 and R6 are as defined herein. The present invention further provides intermediate compounds utilised in said process, and methods for producing said intermediate compounds.

公开(公告)号：US10961248B2

公开(公告)日：2021-03-30

申请号：US16465014

申请日：2017-11-24

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Andrew Edmunds ,  Michel Muehlebach ,  Pierre Joseph Marcel Jung ,  Sebastian Rendler ,  Vikas Sikervar ,  Girish Rawal ,  Indira Sen ,  Régis Jean Georges Mondiere ,  Tomas Smejkal ,  Myriem El Qacemi ,  Denis Gribkov

IPC: C07D487/04 ,  C07D471/04 ,  A01N43/90 ,  C07D487/02 ,  C07D471/02 ,  C07C211/21 ,  C07C211/25 ,  C07C211/40 ,  C07C225/14

Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

公开(公告)号：US20190150441A1

公开(公告)日：2019-05-23

申请号：US15999052

申请日：2017-02-16

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： André Jeanguenat ,  Thomas Pitterna ,  Myriem El Qacemi ,  André Stoller ,  Régis Jean Georges Mondiere ,  Aurelien Bigot ,  Andrew Edmunds ,  Denis Gribkov

IPC: A01N43/56 ,  C07D231/44 ,  C07D401/14 ,  C07D403/04 ,  A01N43/647

Abstract: Compounds of formula (I), as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.