公开(公告)号：US09213031B2

公开(公告)日：2015-12-15

申请号：US13949012

申请日：2013-07-23

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Ji Min Lee ,  Kyung Ah Kim ,  Bo Gyou Kim ,  Young Mi Oh ,  Saet Byoul Lee ,  Yun Ju Jeong

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  C07K16/30 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: G01N33/57492 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of identifying a cell sample or a subject suitable for treatment with an anti-c-Met antibody or antigen binding fragment thereof that specifically binds to an epitope within a SEMA domain of a c-Met protein by determining a Cbl concentration, a Cbl mutation, and/or a mutation of a site of c-Met for interaction with Cbl in a cell sample from a subject, as well as related compositions and methods.

Abstract translation: 一种鉴定细胞样本或适合于用抗c-Met抗体或其抗原结合片段治疗的受试者的方法，所述抗c-Met抗体或其抗原结合片段通过测定Cbl浓度特异性地结合c-Met蛋白质的SEMA结构域中的表位，Cbl 突变和/或与受试者的细胞样品中与Cbl相互作用的c-Met位点的突变，以及相关的组合物和方法。

公开(公告)号：US09956244B2

公开(公告)日：2018-05-01

申请号：US14814278

申请日：2015-07-30

Applicant: Samsung Electronics Co., Ltd.

Inventor： Ji Min Lee ,  Bo Gyou Kim ,  Seung Ja Oh ,  Kyung Ah Kim ,  Saet Byoul Lee ,  Jae Woong Hwang

IPC: G01N33/50 ,  G01N33/574 ,  A61K31/713 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30

CPC classification number: A61K31/713 ,  A61K39/39533 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57484 ,  G01N2800/52 ,  A61K2300/00 ,  A61K31/573

Abstract: A biomarker Hsp90 for predicting an efficacy of a c-Met inhibitor, selecting a subject for application of a c-Met inhibitor, or monitoring an efficacy of a c-Met inhibitor, and a relevant method of using Hsp90.

公开(公告)号：US09943596B2

公开(公告)日：2018-04-17

申请号：US14949303

申请日：2015-11-23

Applicant: Samsung Electronics Co., Ltd.

Inventor： Jimin Lee ,  Bo Gyou Kim ,  Seungja Oh ,  Kyung Ah Kim ,  Powei Lin ,  Saet Byoul Lee

IPC: A61K39/395 ,  A61K31/4985 ,  G01N33/574 ,  A61K31/00 ,  C07K16/28 ,  G01N33/74 ,  A61K39/00

CPC classification number: A61K39/39558 ,  A61K31/00 ,  A61K31/4985 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  G01N33/57492 ,  G01N33/74 ,  G01N2333/65 ,  G01N2800/52

Abstract: A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met and EGFR (hereinafter, ‘c-Met/EGFR dual inhibitor’) and an IGF-1R inhibitor to a subject in need thereof and a use of IGF-1R as a marker for resistance to a c-Met/EGFR dual inhibitor.

公开(公告)号：US09850537B2

公开(公告)日：2017-12-26

申请号：US14604361

申请日：2015-01-23

Applicant: Samsung Electronics Co., Ltd.

Inventor： Bo Gyou Kim ,  Eunjin Lee ,  Kyung Ah Kim ,  Tae Jin Ahn

IPC: A61K39/00 ,  C12Q1/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  G01N33/574

CPC classification number: C12Q1/6876 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N2333/47 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of predicting an effect of a c-Met inhibitor and/or selecting a subject for application of a c-Met inhibitor using TFF1, a method of monitoring an effect of a c-Met inhibitor using TFF1, and a method of treating and/or preventing cancer including administering a c-Met inhibitor to the selected subject.

公开(公告)号：US09808507B2

公开(公告)日：2017-11-07

申请号：US14835376

申请日：2015-08-25

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seungja Oh ,  Kyung Ah Kim ,  Bo Gyou Kim ,  Seung Hyun Lee ,  Ji Min Lee

IPC: C07K16/22 ,  A61K38/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K38/18 ,  A61K38/1891 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

Abstract: An anti-c-Met/anti-Ang2 bispecific antibody including (a) an anti-c-Met antibody or antigen-binding fragment thereof and (b) an anti-Ang2 antibody or antigen-binding fragment thereof, a pharmaceutical composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method using the anti-c-Met/anti-Ang2 bispecific antibody.

公开(公告)号：US09535055B2

公开(公告)日：2017-01-03

申请号：US14229073

申请日：2014-03-28

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Bo Gyou Kim ,  Kyung Ah Kim

IPC: C12Q1/00 ,  G01N33/50 ,  C12Q1/68 ,  G01N33/574

CPC classification number: G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57492 ,  G01N2510/00 ,  G01N2800/52

Abstract: There are provided a composition for determining the efficacy of a c-Met antibody including marker genes and a method for determining the efficacy of a c-Met antibody using the marker genes.

Abstract translation: 提供了用于确定包括标记基因的c-Met抗体的功效的组合物和使用标记基因确定c-Met抗体的功效的方法。

公开(公告)号：US20160090427A1

公开(公告)日：2016-03-31

申请号：US14869636

申请日：2015-09-29

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun Lee ,  Soo Yeon Jung ,  Bo Gyou Kim ,  Seung Ja Oh ,  Ji Min Lee

IPC: C07K16/46 ,  C07K16/32 ,  C07K16/22

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K39/39558 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/74

Abstract: A polypeptide, an anti-VEGF antibody and an anti-c-Met/anti-VEGF bispecific antibody, which includes the polypeptide, a pharmaceutical composition including the antibody, and a method of treating cancer using the antibody.

Abstract translation: 包括该多肽的多肽，抗VEGF抗体和抗c-Met /抗VEGF双特异性抗体，包含该抗体的药物组合物和使用该抗体治疗癌症的方法。