公开(公告)号：US20140154251A1

公开(公告)日：2014-06-05

申请号：US14081917

申请日：2013-11-15

Applicant: Samsung Electronics Co., Ltd.

Inventor： Seung Hyun LEE ,  Geun Woong Kim ,  Kyung Ah Kim ,  Hye Won Park ,  Ho Yeong Song ,  Young Mi Oh ,  Saet Byoul Lee ,  Ji Min Lee ,  Kwang Ho Cheong ,  Yun Ju Jeong ,  Mi Young Cho ,  Jae Hyun Choi ,  Yun Jeong Song ,  Yoon Aa Choi

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

Abstract: An anti-c-Met antibody or antibody fragment and pharmaceutical composition comprising same, as well as a method for preventing and treating cancer by administering the antibody to a subject are provided.

Abstract translation: 提供了抗c-Met抗体或抗体片段及包含其的药物组合物，以及通过向受试者施用抗体来预防和治疗癌症的方法。

公开(公告)号：US09556275B2

公开(公告)日：2017-01-31

申请号：US14244709

申请日：2014-04-03

Applicant: Samsung Electronics Co., Ltd.

Inventor： Yun Ju Jeong ,  Kyung Ah Kim ,  Kyung Eun Kim ,  Chungho Kim

IPC: A61K39/00 ,  C07K16/28 ,  C07K16/22

CPC classification number: C07K16/2863 ,  A61K2039/507 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: A method for inhibiting angiogenesis and treating angiogenesis related diseases comprising administering an anti-c-Met antibody or an antigen-binding fragment thereof, and an anti-Ang-2 antibody or an antigen-binding fragment thereof, in combination simultaneously or sequentially; as well as related compositions and methods.

Abstract translation: 一种抑制血管生成和治疗血管发生相关疾病的方法，包括同时或依次给予抗c-Met抗体或其抗原结合片段，以及抗Ang-2抗体或其抗原结合片段; 以及相关的组合物和方法。

公开(公告)号：US09517266B2

公开(公告)日：2016-12-13

申请号：US14231580

申请日：2014-03-31

Applicant: Samsung Electronics Co., Ltd.

Inventor： In Hwan Lim ,  Dong Uk Kim ,  Geun Woong Kim ,  Hee Kyung Sung ,  Yun Ju Jeong

IPC: A61K39/395 ,  A61K9/00 ,  A61K47/18 ,  A61K47/26 ,  A61K9/08 ,  C07K16/28

CPC classification number: A61K39/39591 ,  A61K9/0019 ,  A61K9/08 ,  A61K47/183 ,  A61K47/26 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/92

Abstract: Disclosed is a method of preparing a stabilized liquid formulation of a protein drug, comprising admixing a protein drug with a composition for stabilization, wherein the composition for stabilization comprises a surfactant, a buffer, and a liquid medium, and has a pH from about 5 to about 8.

Abstract translation: 公开了一种制备蛋白质药物的稳定化液体制剂的方法，其包括将蛋白质药物与用于稳定化的组合物混合，其中用于稳定化的组合物包含表面活性剂，缓冲剂和液体培养基，并且具有约5 至约8。

公开(公告)号：US09233155B2

公开(公告)日：2016-01-12

申请号：US14242638

申请日：2014-04-01

Applicant: Samsung Electronics Co., Ltd.

Inventor： Bo Gyou Kim ,  Ji Min Lee ,  Kyung Ah Kim ,  Yun Ju Jeong

IPC: A61K39/395 ,  C07K16/28 ,  A61K31/4412 ,  A61K39/00

CPC classification number: A61K39/39558 ,  A61K31/4412 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

Abstract: Provided is a method of combination therapy for prevention or treatment of a cancer including or consisting essentially of co-administering sorafenib and an anti-c-Met antibody or an antigen-binding fragment thereof to a subject. The method of combination therapy can achieve an excellent synergistic effect and lower the effective dose of the anti-c-Met antibody, thereby enabling a more effective cancer treatment.

Abstract translation: 本发明提供了一种预防或治疗癌症的组合疗法，包括或主要由对象给予索拉非尼和抗c-Met抗体或其抗原结合片段。 联合治疗方法可以达到优异的协同效应，降低抗c-Met抗体的有效剂量，从而实现更有效的癌症治疗。

公开(公告)号：US09213031B2

公开(公告)日：2015-12-15

申请号：US13949012

申请日：2013-07-23

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Ji Min Lee ,  Kyung Ah Kim ,  Bo Gyou Kim ,  Young Mi Oh ,  Saet Byoul Lee ,  Yun Ju Jeong

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  C07K16/30 ,  A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: G01N33/57492 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of identifying a cell sample or a subject suitable for treatment with an anti-c-Met antibody or antigen binding fragment thereof that specifically binds to an epitope within a SEMA domain of a c-Met protein by determining a Cbl concentration, a Cbl mutation, and/or a mutation of a site of c-Met for interaction with Cbl in a cell sample from a subject, as well as related compositions and methods.

Abstract translation: 一种鉴定细胞样本或适合于用抗c-Met抗体或其抗原结合片段治疗的受试者的方法，所述抗c-Met抗体或其抗原结合片段通过测定Cbl浓度特异性地结合c-Met蛋白质的SEMA结构域中的表位，Cbl 突变和/或与受试者的细胞样品中与Cbl相互作用的c-Met位点的突变，以及相关的组合物和方法。

公开(公告)号：US20150071950A1

公开(公告)日：2015-03-12

申请号：US14485062

申请日：2014-09-12

Applicant: Samsung Electronics Co., Ltd.

Inventor： Su Young Chae ,  Sunghyun Kim ,  Eun Ko ,  Yun Ju Jeong ,  Jae Hyun Choi

IPC: A61K47/48 ,  A61K31/337

CPC classification number: A61K47/6859 ,  A61K47/6803 ,  A61K47/6851

Abstract: Disclosed is a conjugate in which a c-Met targeting compound and a bioactive material are chemically conjugated with each other, and methods of use thereof.

Abstract translation: 公开了一种其中c-Met靶向化合物和生物活性物质彼此化学共轭的缀合物及其使用方法。

公开(公告)号：US20140294830A1

公开(公告)日：2014-10-02

申请号：US14227759

申请日：2014-03-27

Applicant: SAMSUNG LIFE WELFARE FOUNDATION ,  SAMSUNG ELECTRONICS CO., LTD.

Inventor： Saet Byoul LEE ,  Jae Hyun Choi ,  Kyung Ah Kim ,  Ji Min Lee ,  Yun Ju Jeong

IPC: A61K39/395 ,  A61K31/5377 ,  A61K31/517

CPC classification number: A61K39/3955 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/00 ,  A61K2300/00

Abstract: A method of combination therapy for prevention and/or treatment of c-Met- and/or EGFR-induced diseases including co-administering a pharmaceutically effective amount of an EGFR antagonist and a pharmaceutically effective amount of an anti-c-Met antibody to a subject in need thereof is provided.

Abstract translation: 用于预防和/或治疗c-Met-和/或EGFR诱导的疾病的组合疗法的方法，包括将药学有效量的EGFR拮抗剂和药学上有效量的抗c-Met抗体共同施用于 提供了有需要的受试者。