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公开(公告)号：US20110136889A1
公开(公告)日：2011-06-09
申请号：US11910606
申请日：2006-04-10
申请人： Sanjay Bhanot , Brett P. Monia , John Geisler , Robert Mckay , Kenneth W. Dobie
发明人： Sanjay Bhanot , Brett P. Monia , John Geisler , Robert Mckay , Kenneth W. Dobie
CPC分类号： C12N15/1137 , A61K31/202 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3521
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of ACC1 or ACC2 or both in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于在细胞，组织或动物中调节ACC1或ACC2或两者的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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12.发明授权公开(公告)号：US07981868B2
公开(公告)日：2011-07-19
申请号：US10568488
申请日：2004-08-12
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
摘要翻译： 提供了用于治疗和诊断适于通过调节编码p38丝裂原活化蛋白激酶（p38MAPK）的基因的表达进行治疗的疾病或病症的组合物和方法。 还提供了降低动物气道高反应性或气道炎症的方法。
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13.发明申请公开(公告)号：US20080194503A1
公开(公告)日：2008-08-14
申请号：US10568488
申请日：2004-08-12
申请人： Brett P. Monia , Kenneth W. Dobie , Susan M. Freier , Ian Popoff , Wai Shiu Fred Wong , James G. Karras
发明人： Brett P. Monia , Kenneth W. Dobie , Susan M. Freier , Ian Popoff , Wai Shiu Fred Wong , James G. Karras
IPC分类号： A61K31/7052 , C07H21/04
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
摘要翻译： 提供了用于治疗和诊断适于通过调节编码p38丝裂原活化蛋白激酶（p38MAPK）的基因的表达进行治疗的疾病或病症的组合物和方法。 还提供了降低动物气道高反应性或气道炎症的方法。
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公开(公告)号：US08778900B2
公开(公告)日：2014-07-15
申请号：US11042768
申请日：2005-01-24
申请人： Brett P. Monia , Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
发明人： Brett P. Monia , Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP1. Methods of using these compounds for modulation of eIF4E-BP1 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP1 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP1的表达。 组合物包含靶向编码eIF4E-BP1的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP1表达和用于诊断和治疗与eIF4E-BP1表达相关的疾病和病症的方法。
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公开(公告)号：US08258289B2
公开(公告)日：2012-09-04
申请号：US12748281
申请日：2010-03-26
申请人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
发明人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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公开(公告)号：US20130123331A1
公开(公告)日：2013-05-16
申请号：US13566674
申请日：2012-08-03
申请人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
发明人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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公开(公告)号：US08883997B2
公开(公告)日：2014-11-11
申请号：US13566674
申请日：2012-08-03
申请人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
发明人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
IPC分类号： C07H21/04 , C12N15/113 , C07H21/02
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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公开(公告)号：US07825235B2
公开(公告)日：2010-11-02
申请号：US10643801
申请日：2003-08-18
申请人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
发明人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of disease associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病相关的方法 提供二酰基甘油酰基转移酶2的表达。
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公开(公告)号：US07732590B2
公开(公告)日：2010-06-08
申请号：US11066725
申请日：2005-02-24
申请人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
发明人： Sanjay Bhanot , Kenneth W. Dobie , Xing-Xian Yu , Brett P. Monia
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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公开(公告)号：US06284538B1
公开(公告)日：2001-09-04
申请号：US09577902
申请日：2000-05-24
申请人： Brett P. Monia , Lex M. Cowsert , Robert McKay
发明人： Brett P. Monia , Lex M. Cowsert , Robert McKay
IPC分类号： C12N500
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , C40B20/08 , C40B40/06 , C40B50/14 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of PTEN. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTEN. Methods of using these compounds for modulation of PTEN expression and for treatment of diseases and conditions associated with expression of PTEN are provided. Such conditions include diabetes and hyperproliferative conditions. Methods for decreasing blood glucose levels, inhibiting PEPCK expression, decreasing blood insulin levels, decreasing insulin resistance, increasing insulin sensitivity, decreasing blood triglyceride levels or decreasing blood cholesterol levels in an animal using the compounds of the invention are also provided. The animal is preferably a human; also preferably the animal is a diabetic animal.
摘要翻译： 提供反义化合物，组合物和方法用于调节PTEN的表达。 组合物包含靶向编码PTEN的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTEN表达和治疗与PTEN表达相关的疾病和病症的方法。 这些病症包括糖尿病和过度增殖病症。 还提供了使用本发明化合物降低血糖水平，抑制PEPCK表达，降低血胰岛素水平，降低胰岛素抵抗，增加胰岛素敏感性，降低血液甘油三酯水平或降低血液胆固醇水平的方法。 动物最好是人; 还优选地，动物是糖尿病动物。
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