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公开(公告)号：US20100137164A1
公开(公告)日：2010-06-03
申请号：US12607036
申请日：2009-10-27
IPC分类号： C40B40/08
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2500/10
摘要： The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose expression, at the transcriptional and protein levels, is correlated with prostate cancer progression. Methods and kits are described for using these gene expression profiles in the study and/or diagnosis of prostate cancer diseases, in the prediction of prostate cancer progression, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that target these genes or their protein products, in particular for the development of therapeutics for modulating prostate cancer progression.
摘要翻译： 本发明涉及与前列腺癌临床相关的基因表达谱的鉴定和使用。 特别地，本发明提供了在转录和蛋白质水平上表达与前列腺癌进展相关的基因的身份。 描述了在前列腺癌疾病的研究和/或诊断，前列腺癌进展的预测以及治疗方案的选择和/或监测中使用这些基因表达谱的方法和试剂盒。 本发明还涉及靶向这些基因或其蛋白质产物的药物的筛选，特别是用于开发用于调节前列腺癌进展的治疗剂。
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公开(公告)号：US07981609B2
公开(公告)日：2011-07-19
申请号：US11811149
申请日：2007-06-08
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6888 , C12Q2600/156 , G06F19/18
摘要： Described are methods for identifying single nucleotide polymorphism (SNPs) that are useful for analyzing genetic samples, and for using said SNPs to determine genetic identity of samples.
摘要翻译： 描述了用于鉴定可用于分析遗传样品的单核苷酸多态性（SNP）的方法，以及使用所述SNP来确定样品的遗传特性。
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公开(公告)号：US07666595B2
公开(公告)日：2010-02-23
申请号：US11361517
申请日：2006-02-24
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2500/10
摘要： The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose expression, at the transcriptional and protein levels, is correlated with prostate cancer progression. Methods and kits are described for using these gene expression profiles in the study and/or diagnosis of prostate cancer diseases, in the prediction of prostate cancer progression, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that target these genes or their protein products, in particular for the development of therapeutics for modulating prostate cancer progression.
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14.发明申请Spectral Imaging for Measurement of Nuclear Pathology Features in Cancer Cells Prepared for In Situ Analysis 有权用于测量原位分析的癌细胞中核病理特征的光谱成像公开(公告)号：US20140296088A1
公开(公告)日：2014-10-02
申请号：US14115327
申请日：2013-04-23
申请人： Francesca Demichelis , Karl Garsha , Phillip C. Miller , Ray B. Nagle , Michael Otter , Gary Anthony Pestano , Mark Rubin
发明人： Francesca Demichelis , Karl Garsha , Phillip C. Miller , Ray B. Nagle , Michael Otter , Gary Anthony Pestano , Mark Rubin
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/156 , G01N33/57407 , G16B20/00 , H01H35/146 , H01M2/34 , H01M2/345 , H01M2/347 , H01M2/348 , H01M2220/20
摘要： In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
摘要翻译： 一般来说，目前公开的技术涉及癌症亚型的鉴定。 更具体地，该技术涉及使用多变量图像数据确定癌症和/或进展的分子驱动因素的方法，以及怀疑患有b癌症的生物样品的相同细胞中的原位分子标记物和形态特征的统计分析。 这种分析是在单次采集后并行获得分子和解剖形态数据进行的。 该分析将特定的形态学和分子标记与展示癌症的特定遗传驱动因子的已知样品进行比较。 该方法提供统计信息，可以增加对癌症特异性分子驱动因子的识别的信心。
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15.发明授权公开(公告)号：US09951388B2
公开(公告)日：2018-04-24
申请号：US14115327
申请日：2012-05-07
申请人： Francesca Demichelis , Karl Garsha , Phillip C. Miller , Ray B. Nagle , Michael Otter , Gary Anthony Pestano , Mark Rubin
发明人： Francesca Demichelis , Karl Garsha , Phillip C. Miller , Ray B. Nagle , Michael Otter , Gary Anthony Pestano , Mark Rubin
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/156 , G01N33/57407 , G06F19/18 , H01H35/146 , H01M2/34 , H01M2/345 , H01M2/347 , H01M2/348 , H01M2220/20
摘要： In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
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16.发明申请Spectral Imaging for Measurement of Nuclear Pathology Features in Cancer Cells Prepared for In Situ Analysis 有权用于测量原位分析的癌细胞中核病理特征的光谱成像公开(公告)号：US20150197811A9
公开(公告)日：2015-07-16
申请号：US14115327
申请日：2013-04-23
申请人： Francesca Demichelis , Karl Garsha , Phillip C. Miller , Ray B. Nagle , Michael Otter , Gary Anthony Pestano , Mark Rubin
发明人： Francesca Demichelis , Karl Garsha , Phillip C. Miller , Ray B. Nagle , Michael Otter , Gary Anthony Pestano , Mark Rubin
CPC分类号： C12Q1/6886 , C12Q1/6841 , C12Q2600/156 , G01N33/57407 , G06F19/18 , H01H35/146 , H01M2/34 , H01M2/345 , H01M2/347 , H01M2/348 , H01M2220/20
摘要： In general, the presently disclosed technology relates to identification of cancer subtypes. More specifically, the technology relates to methods for determining molecular drivers of cancer and/or progression using a multivariate image data and statistical analysis of in-situ molecular markers and morphological characteristics in the same cells of a biological sample suspected of b cancer. This analysis takes place after a single acquisition that obtains the molecular and anatomic morphology data in parallel. The analysis compares specific morphological and molecular markers to known samples exhibiting particular genetic drivers of the cancer. This method provides statistical information that allows for an increased confidence in the identification of specific molecular drivers of the cancer.
摘要翻译： 一般来说，目前公开的技术涉及癌症亚型的鉴定。 更具体地，该技术涉及使用多变量图像数据确定癌症和/或进展的分子驱动因素的方法，以及怀疑患有b癌症的生物样品的相同细胞中的原位分子标记物和形态特征的统计分析。 这种分析是在单次采集后并行获得分子和解剖形态数据进行的。 该分析将特定的形态学和分子标记与展示癌症的特定遗传驱动因子的已知样品进行比较。 该方法提供统计信息，可以增加对癌症特异性分子驱动因子的识别的信心。
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公开(公告)号：US4331829A
公开(公告)日：1982-05-25
申请号：US193595
申请日：1980-10-03
申请人： Mario Palazzetti , Angioletta Boero , Francesca Demichelis , Enrica Minetti-Mezetti , Giancarlo Ferrari
发明人： Mario Palazzetti , Angioletta Boero , Francesca Demichelis , Enrica Minetti-Mezetti , Giancarlo Ferrari
IPC分类号： H01L31/0216 , H01L31/04 , H01L31/052 , H01L31/054 , H02S10/30
CPC分类号： H01L31/02168 , H01L31/0543 , H01L31/0547 , H02S10/30 , Y02E10/52
摘要： A thermophotovoltaic converter of the type comprising a concentrating optical system and a transducer for solar radiation provided with at least one lens and with at least one photovoltaic cell is described.The principal feature of this converter is that the aforementioned transducer comprises at least a radiator having an irradiating surface substantially facing the sensitive surface of the photovoltaic cell and a selective filter disposed between the photovoltaic cell and the aforementioned radiator.
摘要翻译： 描述了包括集中光学系统和用于太阳辐射的换能器的类型的热光伏转换器，其设置有至少一个透镜和至少一个光伏电池。 该转换器的主要特征在于，上述传感器至少包括具有基本上面对光伏电池的敏感表面的照射表面的散热器和设置在光伏电池和上述散热器之间的选择性过滤器。
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18.发明授权
公开(公告)号：US4287881A
公开(公告)日：1981-09-08
申请号：US119603
申请日：1980-02-07
摘要： A solar energy absorber comprises a thermally-insulated duct housing a plurality of longitudinally-extending absorbing plates and having a slit located at the focal axis of an elongate, optical focusing system. The plates are parallel to the plane of symmetry of the optical system and are spaced apart such that focused energy incident through the slit falls upon an entire surface of each plate, any reflected energy being returned to the plates by a plane mirror located on the opposite side of the plates from the slit and by internal reflecting surfaces of the duct such that substantially all the energy is absorbed: this energy is given up to an air flow through the duct, in use.
摘要翻译： 一种太阳能吸收器包括一个隔热管道，其容纳多个纵向延伸的吸收板，并且具有位于细长光学聚焦系统的焦点轴线处的狭缝。 板平行于光学系统的对称平面并且间隔开，使得通过狭缝入射的聚焦能量落在每个板的整个表面上，任何反射能量通过位于相对的平面镜的平面镜返回到板 这些板从狭缝和管道的内部反射表面一侧使得基本上所有的能量都被吸收：在使用中该能量被放置通过管道的空气流。
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公开(公告)号：US20060234259A1
公开(公告)日：2006-10-19
申请号：US11361517
申请日：2006-02-24
申请人： Mark Rubin , Francesca Demichelis
发明人： Mark Rubin , Francesca Demichelis
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2500/10
摘要： The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose expression, at the transcriptional and protein levels, is correlated with prostate cancer progression. Methods and kits are described for using these gene expression profiles in the study and/or diagnosis of prostate cancer diseases, in the prediction of prostate cancer progression, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that target these genes or their protein products, in particular for the development of therapeutics for modulating prostate cancer progression.
摘要翻译： 本发明涉及与前列腺癌临床相关的基因表达谱的鉴定和使用。 特别地，本发明提供了在转录和蛋白质水平上表达与前列腺癌进展相关的基因的身份。 描述了在前列腺癌疾病的研究和/或诊断，前列腺癌进展的预测以及治疗方案的选择和/或监测中使用这些基因表达谱的方法和试剂盒。 本发明还涉及靶向这些基因或其蛋白质产物的药物的筛选，特别是用于开发用于调节前列腺癌进展的治疗剂。
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