公开(公告)号：US07101969B1

公开(公告)日：2006-09-05

申请号：US09689952

申请日：2000-10-12

申请人： Jerry Pelletier ,  Philippe Gros ,  Mike DuBow

发明人： Jerry Pelletier ,  Philippe Gros ,  Mike DuBow

IPC分类号： C07K14/00 ,  G01N33/53

CPC分类号： C12Q1/025

摘要： This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a Staphylococcus aureus (S. aureus) DnaI related protein, as well as its variants. The invention also relates to a specific interaction between the S. aureus DnaI related protein or specific regions thereof, and a growth-inhibitory protein encoded by the S. aureus bacteriophage 77 genome. The phage open reading frame (ORF) product interacts with amino acids 150–313 of S. aureus DnaI polypeptide, and the invention relates to the use of this interaction target site as the basis of drug screening assays. Accordingly, the invention provides a method for the inhibition of bacterial growth, and the treatment of bacterial infection via the inhibition of DnaI.

摘要翻译： 本发明涉及新鉴定的多核苷酸和多肽及其生产和用途，以及它们的变体，激动剂和拮抗剂及其用途。 特别地，本发明涉及金黄色葡萄球菌（金黄色葡萄球菌）DnaI相关蛋白的多核苷酸和多肽及其变体。 本发明还涉及金黄色葡萄球菌DnaI相关蛋白或其特定区域之间的特异性相互作用以及由金黄色葡萄球菌噬菌体77基因组编码的生长抑制性蛋白。 噬菌体开放阅读框（ORF）产物与金黄色葡萄球菌DnaI多肽的氨基酸150-313相互作用，本发明涉及使用该相互作用靶位点作为药物筛选测定的基础。 因此，本发明提供了通过抑制DnaI来抑制细菌生长和细菌感染的治疗方法。

公开(公告)号：US06982153B1

公开(公告)日：2006-01-03

申请号：US09407804

申请日：1999-09-28

申请人： Jerry Pelletier ,  Philippe Gros ,  Michael DuBow

发明人： Jerry Pelletier ,  Philippe Gros ,  Michael DuBow

IPC分类号： C12P21/02 ,  C07H21/04

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2795/10022 ,  C12N2795/10043 ,  C12Q1/18 ,  Y10S435/883 ,  Y10S530/82

摘要： The disclosure concerns particular bacteriophage open reading frame, and portions and products of those open reading frames which have antimicrobial activity. Methods of using such products are also described.

摘要翻译： 本公开涉及特定的噬菌体开放阅读框，以及具有抗微生物活性的那些开放阅读框的部分和产品。 还描述了使用这些产品的方法。

公开(公告)号：US06737508B1

公开(公告)日：2004-05-18

申请号：US09676519

申请日：2000-09-28

申请人： Jerry Pelletier ,  Philippe Gros ,  Michael DuBow

发明人： Jerry Pelletier ,  Philippe Gros ,  Michael DuBow

IPC分类号： C07K700

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2795/10022 ,  C12N2795/10043 ,  C12Q1/18 ,  Y10S435/883 ,  Y10S530/82

摘要： The disclosure concerns particular bacteriophage open reading frames, and portions and products of those open reading frames which have antimicrobial activity. Methods of using such products are also described.

摘要翻译： 本公开涉及特定的噬菌体开放阅读框，以及具有抗微生物活性的那些开放阅读框的部分和产品。 还描述了使用这些产品的方法。

公开(公告)号：US5726288A

公开(公告)日：1998-03-10

申请号：US102942

申请日：1993-08-02

申请人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  Andre Darveau

发明人： Katherine M. Call ,  Thomas M. Glaser ,  Caryn Y. Ito ,  Alan J. Buckler ,  Jerry Pelletier ,  Daniel A. Haber ,  Elise A. Rose ,  David E. Housman ,  Wendy Bruening ,  Andre Darveau

IPC分类号： C07K14/47 ,  C07K16/30 ,  G01N33/574 ,  C07K14/435

CPC分类号： C07K16/30 ,  C07K14/47 ,  G01N33/57438

摘要： The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four "zinc fingers" and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.