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14 条记录 (耗时 0.055 秒)

    Fragments and variants of Staphylococcus aureus DNAG primase, and uses thereof
    3.
    发明授权
    Fragments and variants of Staphylococcus aureus DNAG primase, and uses thereof 失效
    金黄色葡萄球菌DNAG primase的片段和变体及其用途

    公开(公告)号：US07326541B2

    公开(公告)日：2008-02-05

    申请号：US10025222

    申请日：2001-12-19

    申请人： Jerry Pelletier ,  Philippe Gros ,  Michael DuBow ,  Dominique Bergeron

    发明人： Jerry Pelletier ,  Philippe Gros ,  Michael DuBow ,  Dominique Bergeron

    IPC分类号： C12Q1/48 ,  C12N9/12 ,  C07K1/00

    CPC分类号： G01N33/6893 ,  A61K38/00 ,  C07K14/31 ,  C12Q1/18 ,  G01N2500/00

    摘要： The invention relates to bacterial genes and proteins that are implicated in the process of DNA replication and also to bacteriophage genes and their protein products that interact with bacterial proteins involved in DNA replication. More particularly, the invention relates to compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein STAAU_R9. In addition, the invention relates to screening assays to identify compounds which modulate the level and/or activity of STAAU_R9 and to such compounds.

    摘要翻译： 本发明涉及涉及DNA复制过程的细菌基因和蛋白质，还涉及与参与DNA复制的细菌蛋白相互作用的噬菌体基因及其蛋白质产物。 更具体地说，本发明涉及涉及必需的金黄色葡萄球菌基因及其编码蛋白质STAAU_R9的组合物和方法。 此外，本发明涉及筛选测定以鉴定调节STAAU_R9和这些化合物的水平和/或活性的化合物。

    Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein
    6.
    发明授权
    Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein 失效
    涉及金黄色葡萄球菌基因及其编码蛋白的组成和方法

    公开(公告)号：US07101969B1

    公开(公告)日：2006-09-05

    申请号：US09689952

    申请日：2000-10-12

    申请人： Jerry Pelletier ,  Philippe Gros ,  Mike DuBow

    发明人： Jerry Pelletier ,  Philippe Gros ,  Mike DuBow

    IPC分类号： C07K14/00 ,  G01N33/53

    CPC分类号： C12Q1/025

    摘要： This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a Staphylococcus aureus (S. aureus) DnaI related protein, as well as its variants. The invention also relates to a specific interaction between the S. aureus DnaI related protein or specific regions thereof, and a growth-inhibitory protein encoded by the S. aureus bacteriophage 77 genome. The phage open reading frame (ORF) product interacts with amino acids 150–313 of S. aureus DnaI polypeptide, and the invention relates to the use of this interaction target site as the basis of drug screening assays. Accordingly, the invention provides a method for the inhibition of bacterial growth, and the treatment of bacterial infection via the inhibition of DnaI.

    摘要翻译： 本发明涉及新鉴定的多核苷酸和多肽及其生产和用途，以及它们的变体，激动剂和拮抗剂及其用途。 特别地，本发明涉及金黄色葡萄球菌（金黄色葡萄球菌）DnaI相关蛋白的多核苷酸和多肽及其变体。 本发明还涉及金黄色葡萄球菌DnaI相关蛋白或其特定区域之间的特异性相互作用以及由金黄色葡萄球菌噬菌体77基因组编码的生长抑制性蛋白。 噬菌体开放阅读框（ORF）产物与金黄色葡萄球菌DnaI多肽的氨基酸150-313相互作用，本发明涉及使用该相互作用靶位点作为药物筛选测定的基础。 因此，本发明提供了通过抑制DnaI来抑制细菌生长和细菌感染的治疗方法。

    Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein
    7.
    发明授权
    Compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein 失效
    涉及金黄色葡萄球菌基因及其编码蛋白的组成和方法

    公开(公告)号：US06376652B1

    公开(公告)日：2002-04-23

    申请号：US09470512

    申请日：1999-12-22

    申请人： Jerry Pelletier ,  Philippe Gros ,  Mike DuBow

    发明人： Jerry Pelletier ,  Philippe Gros ,  Mike DuBow

    IPC分类号： C07K1400

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2795/10022 ,  C12N2795/10043 ,  C12Q1/18

    摘要： This invention relates to newly identified polynucleotides and polypeptides, and their production and uses, as well as their variants, agonists and antagonists, and their uses. In particular, the invention relates to polynucleotides and polypeptides of a Staphylococcus aureus (S. aureus) DnaI related protein, as well as its variants, hereinafter referred to as “S. aureus DnaI”, “S. aureus DnaI polypeptide(s)”, and “S. aureus dnaI polynucleotides” as the case may be. Also, the invention relates to a specific interaction between the S. aureus DnaI related protein and a growth-inhibitory protein encoded by the S. aureus bacteriophage 77 genome. The phage ORF product interacts with the S. aureus DnaI polypeptide, and the invention contemplates use of this interaction target site for the basis of a drug screening assay. In addition, the invention relates to polynucleotides and polypeptides of a protein complex containing S. aureus DnaI and DnaC related proteins, as well as their variants.

    摘要翻译： 本发明涉及新鉴定的多核苷酸和多肽及其生产和用途，以及它们的变体，激动剂和拮抗剂及其用途。 特别地，本发明涉及金黄色葡萄球菌（金黄色葡萄球菌）DnaI相关蛋白的多核苷酸和多肽，以及其变体，以下称为“金黄色葡萄球菌DnaI”，“金黄色葡萄球菌DnaI多肽” 和“金黄色葡萄球菌dnaI多核苷酸”的情况。 此外，本发明涉及金黄色葡萄球菌DnaI相关蛋白与由金黄色葡萄球菌噬菌体77基因组编码的生长抑制性蛋白质之间的特异性相互作用。 噬菌体ORF产物与金黄色葡萄球菌DnaI多肽相互作用，本发明考虑使用该相互作用靶位点进行药物筛选测定。 此外，本发明涉及含有金黄色葡萄球菌DnaI和DnaC相关蛋白质的蛋白质复合物的多核苷酸和多肽，以及它们的变体。

    DNA sequences that encode a natural resistance to infection with intracellular parasites
    8.
    发明授权
    DNA sequences that encode a natural resistance to infection with intracellular parasites 失效
    编码天然抵抗细胞内寄生虫感染的DNA序列

    公开(公告)号：US06184031B2

    公开(公告)日：2001-02-06

    申请号：US08637823

    申请日：1996-05-08

    申请人： Philippe Gros ,  Emil Skamene ,  Danielle Malo ,  Silvia Vidal

    发明人： Philippe Gros ,  Emil Skamene ,  Danielle Malo ,  Silvia Vidal

    IPC分类号： C07H2104

    CPC分类号： C07K14/47 ,  C12N15/11

    摘要： The present invention relates to mouse and human cDNAs for a gene family designated Nramp (natural resistance-associated macrophage protein), involved in macrophage function and responsible for the natural resistance to infection with intracellular parasites, and to the isolation of Nramp sequences from other animal sources. The nucleotide sequences of the mouse and human cDNAs are disclosed, as are the amino sequences of the encoded products. The cDNAs can be expressed in expression constructs. These expression constructs and the proteins produced therefrom can be used for a variety of purposes including diagnostic and therapeutic methods.

    摘要翻译： 本发明涉及涉及巨噬细胞功能并负责天然抗细胞内寄生虫感染的Nramp（天然抗性相关巨噬细胞蛋白）的基因家族的小鼠和人类cDNA，以及从其他动物分离Nramp序列 来源。 公开了小鼠和人cDNA的核苷酸序列，以及编码产物的氨基序列。 cDNA可以在表达构建体中表达。 这些表达构建体和由其产生的蛋白质可以用于各种目的，包括诊断和治疗方法。

    DNA sequence that encodes the multidrug resistance gene
    10.
    发明授权
    DNA sequence that encodes the multidrug resistance gene 失效
    编码多药耐药基因的DNA序列

    公开(公告)号：US5198344A

    公开(公告)日：1993-03-30

    申请号：US652311

    申请日：1991-02-06

    申请人： James M. Croop ,  Philippe Gros ,  David E. Housman

    发明人： James M. Croop ,  Philippe Gros ,  David E. Housman

    IPC分类号： A61K38/00 ,  C07K14/705 ,  C12N15/67

    CPC分类号： C12N15/67 ,  C07K14/705 ,  A61K38/00

    摘要： SPONSORSHIPThe invention described herein was supported by a grant from the Medical Research Council of Canada, grants from the National Institutes of Health and a grant from the Ajinomoto Corporation.

    摘要翻译： 与药物敏感的哺乳动物细胞中以显着增加的水平表达的mRNA同源的DNA在引入这些细胞时赋予对药物敏感的哺乳动物细胞上的各种药物的抗性。 公开了作为编码产物的氨基酸序列的DNA，其是多药耐药（mdr）基因的小家族成员之一的核苷酸序列。 还描述了赋予药物敏感性哺乳动物细胞多药耐药性表型的方法，检测mdr基因发生的方法，以及由mdr DNA编码的蛋白质特异的抗体。