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1.发明申请Development of novel anti-microbial agents based on bacteriophage genomics 审中-公开基于噬菌体基因组学的新型抗微生物剂的开发公开(公告)号：US20070020614A1
公开(公告)日：2007-01-25
申请号：US10376078
申请日：2003-02-26
申请人： Jerry Pelletier , Philippe Gros , Michael DuBow
发明人： Jerry Pelletier , Philippe Gros , Michael DuBow
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , C12N2795/10022 , C12N2795/10043 , C12Q1/18 , Y10S435/883 , Y10S530/82
摘要： A method for identifying suitable targets for antibacterial agents based on identifying targets of bacteriophage-encoded proteins is described. Also described are compositions useful in the identification methods and in inhibiting bacterial growth, and methods for preparing and using such compositions.
摘要翻译： 描述了基于识别噬菌体编码的蛋白质的靶标来鉴定抗菌剂的合适靶标的方法。 还描述了可用于鉴定方法和抑制细菌生长的组合物，以及用于制备和使用这些组合物的方法。
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2.发明授权公开(公告)号：US06783930B1
公开(公告)日：2004-08-31
申请号：US09454252
申请日：1999-12-02
申请人： Jerry Pelletier , Philippe Gros , Michael DuBow
发明人： Jerry Pelletier , Philippe Gros , Michael DuBow
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K38/00 , C12N2795/10022 , C12N2795/10043 , C12Q1/18 , Y10S435/883 , Y10S530/82
摘要： A method for identifying suitable targets for antibacterial agents based on identifying targets of bacteriophage-encoded proteins is described. Also described are compositions useful in the identification methods and in inhibiting bacterial growth, and methods for preparing and using such compositions.
摘要翻译： 描述了基于识别噬菌体编码的蛋白质的靶标来鉴定抗菌剂的合适靶标的方法。 还描述了可用于鉴定方法和抑制细菌生长的组合物，以及用于制备和使用这些组合物的方法。
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3.发明授权Fragments and variants of Staphylococcus aureus DNAG primase, and uses thereof 失效金黄色葡萄球菌DNAG primase的片段和变体及其用途公开(公告)号：US07326541B2
公开(公告)日：2008-02-05
申请号：US10025222
申请日：2001-12-19
CPC分类号： G01N33/6893 , A61K38/00 , C07K14/31 , C12Q1/18 , G01N2500/00
摘要： The invention relates to bacterial genes and proteins that are implicated in the process of DNA replication and also to bacteriophage genes and their protein products that interact with bacterial proteins involved in DNA replication. More particularly, the invention relates to compositions and methods involving an essential Staphylococcus aureus gene and its encoded protein STAAU_R9. In addition, the invention relates to screening assays to identify compounds which modulate the level and/or activity of STAAU_R9 and to such compounds.
摘要翻译： 本发明涉及涉及DNA复制过程的细菌基因和蛋白质，还涉及与参与DNA复制的细菌蛋白相互作用的噬菌体基因及其蛋白质产物。 更具体地说，本发明涉及涉及必需的金黄色葡萄球菌基因及其编码蛋白质STAAU_R9的组合物和方法。 此外，本发明涉及筛选测定以鉴定调节STAAU_R9和这些化合物的水平和/或活性的化合物。
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4.发明授权DNA sequences from staphylococcus aureus bacteriophage 77 that encode anti-microbial polypeptides 失效编码抗微生物多肽的金黄色葡萄球菌噬菌体77的DNA序列公开(公告)号：US06982153B1
公开(公告)日：2006-01-03
申请号：US09407804
申请日：1999-09-28
申请人： Jerry Pelletier , Philippe Gros , Michael DuBow
发明人： Jerry Pelletier , Philippe Gros , Michael DuBow
CPC分类号： C07K14/005 , A61K38/00 , C12N2795/10022 , C12N2795/10043 , C12Q1/18 , Y10S435/883 , Y10S530/82
摘要： The disclosure concerns particular bacteriophage open reading frame, and portions and products of those open reading frames which have antimicrobial activity. Methods of using such products are also described.
摘要翻译： 本公开涉及特定的噬菌体开放阅读框，以及具有抗微生物活性的那些开放阅读框的部分和产品。 还描述了使用这些产品的方法。
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5.发明授权DNA sequences from staphylococus aureus bacteriophages 3A, 77, and 96 that encode anti-microbial polypeptides 失效编码抗微生物多肽的金黄色葡萄球菌噬菌体3A，77和96的DNA序列公开(公告)号：US06737508B1
公开(公告)日：2004-05-18
申请号：US09676519
申请日：2000-09-28
申请人： Jerry Pelletier , Philippe Gros , Michael DuBow
发明人： Jerry Pelletier , Philippe Gros , Michael DuBow
IPC分类号： C07K700
CPC分类号： C07K14/005 , A61K38/00 , C12N2795/10022 , C12N2795/10043 , C12Q1/18 , Y10S435/883 , Y10S530/82
摘要： The disclosure concerns particular bacteriophage open reading frames, and portions and products of those open reading frames which have antimicrobial activity. Methods of using such products are also described.
摘要翻译： 本公开涉及特定的噬菌体开放阅读框，以及具有抗微生物活性的那些开放阅读框的部分和产品。 还描述了使用这些产品的方法。
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