公开(公告)号：US20200255895A1

公开(公告)日：2020-08-13

申请号：US16862314

申请日：2020-04-29

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Kim Yang LEE ,  David S. KUO ,  Thomas Young CHANG ,  Xiaomin YANG ,  ShuaiGang XIAO ,  Koichi WAGO

IPC: C12Q1/6874 ,  G01N27/447 ,  G01N33/487

Abstract: A DNA sequencing device, and related methods, include a nanochannel sized to receive a DNA strand, a first electrode member exposed within the nanochannel, and a second electrode member exposed within the nanochannel and spaced apart from the first electrode to form an electrode gap. The second electrode member has a wedge shaped profile, and the first and second electrode members are operable to detect a change in electronic signal as the DNA strand passes through the electrode gap.

公开(公告)号：US20180245149A1

公开(公告)日：2018-08-30

申请号：US15886560

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： ShuaiGang XIAO ,  David S. KUO ,  Kim Yang LEE ,  Xiaomin YANG ,  Koichi WAGO ,  Thomas Young CHANG

IPC: C12Q1/6874 ,  G06F19/22 ,  G01N27/447 ,  B82Y40/00

CPC classification number: C12Q1/6874 ,  B82Y15/00 ,  B82Y40/00 ,  C12Q1/6869 ,  G01N27/44791 ,  G16B30/00 ,  C12Q2565/631

Abstract: A nanochannel DNA sequencing device and related methods of fabrication and of DNA sequencing are provided. In one example, a device may include a nanochannel having a width of no greater than about 2 nm and a height no greater than 1.5 times the width. The device may further include a pair of electrodes having a width of no greater than about 10 nm, the electrodes being exposed within the nanochannel to measure electronical characteristics of a DNA strand passing through the nanochannel. In one example, the nanochannel may be formed using lithography techniques, such as sidewall lithography.

公开(公告)号：US20180217084A1

公开(公告)日：2018-08-02

申请号：US15886685

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： David S. KUO ,  ShuaiGang XIAO ,  Kim Yang LEE ,  Xiaomin YANG ,  Koichi WAGO ,  Thomas Young CHANG

IPC: G01N27/327 ,  G01N33/487 ,  G01N33/543 ,  C12Q1/6869 ,  B82Y5/00 ,  B82Y40/00

CPC classification number: G01N27/3278 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C12Q1/6869 ,  G01N33/48721 ,  G01N33/5438

Abstract: A DNA sequencing device includes a first layer having a nanochannel formed therein, and a pair of electrodes arranged vertically relative to each other and spaced apart to define an electrode gap. The electrode gap is exposed in the nanochannel, and the electrode gap is in the range of about 0.3 nm to about 2 nm.

公开(公告)号：US20180216180A1

公开(公告)日：2018-08-02

申请号：US15886661

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Kim Yang LEE ,  David S. KUO ,  Thomas Young CHANG ,  Xiaomin YANG ,  ShuaiGang XIAO ,  Koichi WAGO

IPC: C12Q1/6874 ,  G01N27/447 ,  G01N33/487

CPC classification number: C12Q1/6874 ,  C12Q1/6869 ,  G01N27/44791 ,  G01N33/48721

Abstract: A DNA sequencing device, and related methods, include a nanochannel sized to receive a DNA strand, a first electrode member exposed within the nanochannel, and a second electrode member exposed within the nanochannel and spaced apart from the first electrode to form an electrode gap. The second electrode member has a wedge shaped profile, and the first and second electrode members are operable to detect a change in electronic signal as the DNA strand passes through the electrode gap.

公开(公告)号：US20180216178A1

公开(公告)日：2018-08-02

申请号：US15886511

申请日：2018-02-01

Applicant: SEAGATE TECHNOLOGY LLC

Inventor： Kim Yang LEE ,  Thomas Young CHANG ,  David S. KUO ,  ShuaiGang XIAO ,  Xiaomin YANG ,  Koichi WAGO

IPC: C12Q1/6869 ,  G01N27/327 ,  G01N27/447 ,  B81C1/00

CPC classification number: C12Q1/6869 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/0896 ,  B81B2201/032 ,  B81B2201/058 ,  B81B2203/0109 ,  B81C1/00071 ,  G01N27/3278 ,  G01N27/447 ,  G01N27/44791 ,  C12Q2565/607 ,  C12Q2565/629

Abstract: A DNA sequencing device and related methods, wherein the device includes a substrate, a nanochannel formed in the substrate, a first electrode positioned on a first side of the nanochannel, and a second electrode. The second electrode is positioned on a second side of the nanochannel opposite the first electrode, and is spaced apart from the first electrode to form an electrode gap that is exposed in the nanochannel. At least a portion of first electrode is movable relative to the second electrode to decrease a size of the electrode gap.