-
公开(公告)号：US08314087B2
公开(公告)日：2012-11-20
申请号：US12070309
申请日：2008-02-15
申请人： Brian K. Albrecht , Steven Bellon , Shon Booker , Alan C. Cheng , Derin D'Amico , Noel D'Angelo , Jean-Christophe Harmange , Tae-Seong Kim , Longbin Liu , Mark H. Norman , Aaron C. Siegmund , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , Steven Bellon , Shon Booker , Alan C. Cheng , Derin D'Amico , Noel D'Angelo , Jean-Christophe Harmange , Tae-Seong Kim , Longbin Liu , Mark H. Norman , Aaron C. Siegmund , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： C07D215/233 , C07D413/14 , C07D205/08 , C07D409/14 , C07D401/14 , C07D239/36 , A61K31/4709 , A61K31/5355 , A61K31/397 , A61K31/497 , A61K31/506 , A61P35/00
CPC分类号： C07D237/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US20080280917A1
公开(公告)日：2008-11-13
申请号：US12070309
申请日：2008-02-15
申请人： Brian K. Albrecht , Steven Bellon , Shon Booker , Alan C. Cheng , Derin D'Amico , Noel D'Angelo , Jean-Christophe Harmange , Tae-Seong Kim , Longbin Liu , Mark H. Norman , Aaron C. Siegmund , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , Steven Bellon , Shon Booker , Alan C. Cheng , Derin D'Amico , Noel D'Angelo , Jean-Christophe Harmange , Tae-Seong Kim , Longbin Liu , Mark H. Norman , Aaron C. Siegmund , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： A61K31/501 , C07D403/12 , A61K31/4709 , A61P25/00 , A61P35/00 , C07D471/00
CPC分类号： C07D237/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US20110092504A1
公开(公告)日：2011-04-21
申请号：US12995431
申请日：2009-05-29
申请人： Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
发明人： Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/10 , C07D215/233 , A61K31/4709 , A61K31/47 , A61K31/498 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物，其中Q，X 1，X 2，R 1和Z如本文所定义。
-
公开(公告)号：US08415376B2
公开(公告)日：2013-04-09
申请号：US12995431
申请日：2009-05-29
申请人： Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
发明人： Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
IPC分类号： A61K31/47 , C07D401/02 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物，其中Q，X 1，X 2，R 1和Z如本文所定义。
-
公开(公告)号：US08524900B2
公开(公告)日：2013-09-03
申请号：US13309488
申请日：2011-12-01
申请人： Brian K. Albrecht , David Bauer , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. Albrecht , David Bauer , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D401/12 , C07D401/14 , C07D413/14 , A61K31/5025 , A61K31/4353 , A61K31/4523 , A61P35/00
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
-
公开(公告)号：US20110118252A1
公开(公告)日：2011-05-19
申请号：US12945575
申请日：2010-11-12
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/4709 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , A61K31/497 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501 , A61P35/00
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US07915287B2
公开(公告)日：2011-03-29
申请号：US12004153
申请日：2007-12-19
申请人： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
发明人： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
IPC分类号： A61K31/5377 , A61K31/444 , A61K31/4709 , A61K31/506 , A61P35/00 , C07D413/14 , C07D401/12 , C07D401/14
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US20080312232A1
公开(公告)日：2008-12-18
申请号：US11412302
申请日：2006-04-26
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/5377 , C07D413/12 , C07D401/14 , A61K31/4709 , C07D403/12 , A61K31/506 , A61K31/501 , C07D401/12 , A61K31/496
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US20080214544A1
公开(公告)日：2008-09-04
申请号：US12004284
申请日：2007-12-19
申请人： Steven Bellon , Shon Booker , Noel D'Angelo , Ingrid M. Fellows , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman
发明人： Steven Bellon , Shon Booker , Noel D'Angelo , Ingrid M. Fellows , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman
IPC分类号： A61K31/5377 , C07D403/12 , C07D413/14 , A61K31/496 , A61P29/00 , A61P19/02 , A61P35/00 , A61P3/10 , C07D401/14 , A61K31/513
CPC分类号： C07D401/14 , C07D401/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as c-met mediated diseases and/or HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 选择的化合物对于预防和治疗诸如c-met介导的疾病和/或HGF介导的疾病的疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
公开(公告)号：US20080200464A1
公开(公告)日：2008-08-21
申请号：US12004153
申请日：2007-12-19
申请人： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
发明人： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/14 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D401/12 , A61P35/00
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译： 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
-
-
-
-
-
-
-
-
-
搜索结果
68 条记录 (耗时 0.064 秒)
