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公开(公告)号：US20090324688A1
公开(公告)日：2009-12-31
申请号：US12540305
申请日：2009-08-12
申请人： Eugene R. COOPER , David Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. COOPER , David Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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公开(公告)号：US20090324687A1
公开(公告)日：2009-12-31
申请号：US12533998
申请日：2009-07-31
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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公开(公告)号：US07585517B2
公开(公告)日：2009-09-08
申请号：US10945682
申请日：2004-09-20
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J M Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J M Dor , Sreenivasu Mudumba
IPC分类号： A61F2/00 , C12P21/04 , A61K38/00 , A61K31/44 , A61K31/445
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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公开(公告)号：US20090324686A1
公开(公告)日：2009-12-31
申请号：US12511937
申请日：2009-07-29
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J.M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J.M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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公开(公告)号：US08492400B2
公开(公告)日：2013-07-23
申请号：US11704442
申请日：2007-02-09
IPC分类号： A61K31/445
CPC分类号： A61K31/436 , A61K31/445 , A61K31/4745 , A61K33/00 , A61K45/06 , B01F13/02
摘要： Described herein are formulations comprising therapeutic agents, including but not limited to formulations comprising rapamycin, pharmaceutical formulations, unit dose forms, kits, methods of preparing formulations, and methods of using formulations. Such formulations and methods have increased stability.
摘要翻译： 本文描述的是包含治疗剂的制剂，包括但不限于包含雷帕霉素的制剂，药物制剂，单位剂量形式，试剂盒，制剂的制备方法和使用制剂的方法。 这些制剂和方法具有增加的稳定性。
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公开(公告)号：US20090324689A1
公开(公告)日：2009-12-31
申请号：US12541085
申请日：2009-08-13
申请人： Eugene R. COOPER , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. COOPER , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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公开(公告)号：US20120034279A1
公开(公告)日：2012-02-09
申请号：US13279179
申请日：2011-10-21
申请人： Eugene R. COOPER , David M. Kleinman , Thierry Nivaggioli , Philippe JM Dor , Sreenivasu Mudumba
发明人： Eugene R. COOPER , David M. Kleinman , Thierry Nivaggioli , Philippe JM Dor , Sreenivasu Mudumba
IPC分类号： A61K9/14 , A61P27/02 , A61K31/439
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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公开(公告)号：US20090324690A1
公开(公告)日：2009-12-31
申请号：US12541866
申请日：2009-08-14
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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公开(公告)号：US20070203173A1
公开(公告)日：2007-08-30
申请号：US11704442
申请日：2007-02-09
IPC分类号： A61K31/4745
CPC分类号： A61K31/436 , A61K31/445 , A61K31/4745 , A61K33/00 , A61K45/06 , B01F13/02
摘要： Described herein are formulations comprising therapeutic agents, including but not limited to formulations comprising rapamycin, pharmaceutical formulations, unit dose forms, kits, methods of preparing formulations, and methods of using formulations. Such formulations and methods have increased stability.
摘要翻译： 本文描述的是包含治疗剂的制剂，包括但不限于包含雷帕霉素的制剂，药物制剂，单位剂量形式，试剂盒，制剂的制备方法和使用制剂的方法。 这些制剂和方法具有增加的稳定性。
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20.发明授权公开(公告)号：US07976867B2
公开(公告)日：2011-07-12
申请号：US10735318
申请日：2003-12-12
申请人： Charles E. Lundy , Gary Wynn Cleary , Adrian Louis Faasse , Michael George Marcoux , Sreenivasu Mudumba
发明人： Charles E. Lundy , Gary Wynn Cleary , Adrian Louis Faasse , Michael George Marcoux , Sreenivasu Mudumba
CPC分类号： A61K9/703 , A61K9/7084 , A61K31/60
摘要： A dermal, transdermal, mucosal or transmucosal delivery device is provided. The device includes a backing layer, defining an ingredient containing reservoir, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the dermis or mucosa.
摘要翻译： 提供了皮肤，透皮，粘膜或经粘膜递送装置。 该装置包括背衬层，限定含有成分的储存器，用于储存器的盖具有穿过其中的至少一个开口，粘合剂层和衬垫层。 在去除衬里层时，可以将装置放置在皮肤或粘膜的期望区域上并粘附施加于其上，从而允许成分从储存器流过至少一个开口至真皮或粘膜。
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