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公开(公告)号：US20090324687A1
公开(公告)日：2009-12-31
申请号：US12533998
申请日：2009-07-31
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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公开(公告)号：US07585517B2
公开(公告)日：2009-09-08
申请号：US10945682
申请日：2004-09-20
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J M Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J M Dor , Sreenivasu Mudumba
IPC分类号： A61F2/00 , C12P21/04 , A61K38/00 , A61K31/44 , A61K31/445
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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公开(公告)号：US20090324689A1
公开(公告)日：2009-12-31
申请号：US12541085
申请日：2009-08-13
申请人： Eugene R. COOPER , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. COOPER , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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公开(公告)号：US20090324690A1
公开(公告)日：2009-12-31
申请号：US12541866
申请日：2009-08-14
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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公开(公告)号：US20090324686A1
公开(公告)日：2009-12-31
申请号：US12511937
申请日：2009-07-29
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J.M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J.M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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公开(公告)号：US20120034279A1
公开(公告)日：2012-02-09
申请号：US13279179
申请日：2011-10-21
申请人： Eugene R. COOPER , David M. Kleinman , Thierry Nivaggioli , Philippe JM Dor , Sreenivasu Mudumba
发明人： Eugene R. COOPER , David M. Kleinman , Thierry Nivaggioli , Philippe JM Dor , Sreenivasu Mudumba
IPC分类号： A61K9/14 , A61P27/02 , A61K31/439
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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7.发明授权Formulations and methods for vascular permeability-related diseases or conditions 有权血管通透性相关疾病或病症的制剂和方法公开(公告)号：US08222271B2
公开(公告)日：2012-07-17
申请号：US11726813
申请日：2007-03-23
CPC分类号： A61K31/436 , A61K47/10
摘要： Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.
摘要翻译： 本文描述了用于治疗，抑制，预防，延缓发作或导致与血管通透性有关的疾病或病症消退的制剂和方法。
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8.发明授权Formulations and methods for vascular permeability-related diseases or conditions 有权血管通透性相关疾病或病症的制剂和方法公开(公告)号：US08486960B2
公开(公告)日：2013-07-16
申请号：US13530025
申请日：2012-06-21
CPC分类号： A61K31/436 , A61K47/10
摘要： Described herein are formulations and methods for treating, inhibiting, preventing, delaying onset, or causing regression of a disease or condition relating to vascular permeability.
摘要翻译： 本文描述了用于治疗，抑制，预防，延缓发作或导致与血管通透性有关的疾病或病症消退的制剂和方法。
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9.发明申请BI-FUNCTIONAL CO-POLYMER USE FOR OPTHALMIC AND OTHER TOPICAL AND LOCAL APPLICATIONS 有权双功能聚合物用于非对称和其他局部和本地应用公开(公告)号：US20100226963A1
公开(公告)日：2010-09-09
申请号：US12708329
申请日：2010-02-18
CPC分类号： A61K31/785 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0073 , A61K9/5031 , A61K9/5146 , A61K31/045 , A61K31/7036 , A61K31/74 , A61K31/765 , A61K35/02 , A61K45/06 , A61K47/34 , G02C7/04
摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
摘要翻译： 本发明涉及一种共聚物，其是可用于改变生物表面的润湿性和表面特性的接枝或嵌段共聚物。 使用这些制剂和涂层以改变受试者的润湿性和空间稳定性以及润滑生物表面的方法，例如治疗干眼综合征，以及防止不需要的蛋白质的粘附，例如用于治疗隐形眼镜 不容忍，被提供。
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10.发明授权Bi-functional co-polymer use for opthalmic and other topical and local applications 有权双功能共聚物用于眼科和其他局部和局部应用公开(公告)号：US08802075B2
公开(公告)日：2014-08-12
申请号：US12708329
申请日：2010-02-18
CPC分类号： A61K31/785 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0073 , A61K9/5031 , A61K9/5146 , A61K31/045 , A61K31/7036 , A61K31/74 , A61K31/765 , A61K35/02 , A61K45/06 , A61K47/34 , G02C7/04
摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
摘要翻译： 本发明涉及一种共聚物，其是可用于改变生物表面的润湿性和表面特性的接枝或嵌段共聚物。 使用这些制剂和涂层以改变受试者的润湿性和空间稳定性以及润滑生物表面的方法，例如治疗干眼综合征，以及防止不需要的蛋白质的粘附，例如用于治疗隐形眼镜 不容忍，被提供。
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