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公开(公告)号：US20090324687A1
公开(公告)日：2009-12-31
申请号：US12533998
申请日：2009-07-31
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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公开(公告)号：US07585517B2
公开(公告)日：2009-09-08
申请号：US10945682
申请日：2004-09-20
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J M Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J M Dor , Sreenivasu Mudumba
IPC分类号： A61F2/00 , C12P21/04 , A61K38/00 , A61K31/44 , A61K31/445
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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公开(公告)号：US20090324690A1
公开(公告)日：2009-12-31
申请号：US12541866
申请日：2009-08-14
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J. M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。
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公开(公告)号：US20090324686A1
公开(公告)日：2009-12-31
申请号：US12511937
申请日：2009-07-29
申请人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J.M. Dor , Sreenivasu Mudumba
发明人： Eugene R. Cooper , David M. Kleinman , Thierry Nivaggioli , Philippe J.M. Dor , Sreenivasu Mudumba
IPC分类号： A61K9/00 , A61K31/436 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/0019 , A61K31/436
摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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5.发明申请BI-FUNCTIONAL CO-POLYMER USE FOR OPTHALMIC AND OTHER TOPICAL AND LOCAL APPLICATIONS 有权双功能聚合物用于非对称和其他局部和本地应用公开(公告)号：US20100226963A1
公开(公告)日：2010-09-09
申请号：US12708329
申请日：2010-02-18
CPC分类号： A61K31/785 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0073 , A61K9/5031 , A61K9/5146 , A61K31/045 , A61K31/7036 , A61K31/74 , A61K31/765 , A61K35/02 , A61K45/06 , A61K47/34 , G02C7/04
摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
摘要翻译： 本发明涉及一种共聚物，其是可用于改变生物表面的润湿性和表面特性的接枝或嵌段共聚物。 使用这些制剂和涂层以改变受试者的润湿性和空间稳定性以及润滑生物表面的方法，例如治疗干眼综合征，以及防止不需要的蛋白质的粘附，例如用于治疗隐形眼镜 不容忍，被提供。
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6.发明授权Bi-functional co-polymer use for opthalmic and other topical and local applications 有权双功能共聚物用于眼科和其他局部和局部应用公开(公告)号：US08802075B2
公开(公告)日：2014-08-12
申请号：US12708329
申请日：2010-02-18
CPC分类号： A61K31/785 , A61K9/0019 , A61K9/0043 , A61K9/0048 , A61K9/0051 , A61K9/0073 , A61K9/5031 , A61K9/5146 , A61K31/045 , A61K31/7036 , A61K31/74 , A61K31/765 , A61K35/02 , A61K45/06 , A61K47/34 , G02C7/04
摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
摘要翻译： 本发明涉及一种共聚物，其是可用于改变生物表面的润湿性和表面特性的接枝或嵌段共聚物。 使用这些制剂和涂层以改变受试者的润湿性和空间稳定性以及润滑生物表面的方法，例如治疗干眼综合征，以及防止不需要的蛋白质的粘附，例如用于治疗隐形眼镜 不容忍，被提供。
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7.发明申请OPHTHALMIC FORMULATIONS OF REVERSED LIQUID CRYSTALLINE PHASE MATERIALS AND METHODS OF USING 审中-公开反相液晶相材料的透镜配方及使用方法公开(公告)号：US20110177169A1
公开(公告)日：2011-07-21
申请号：US12833516
申请日：2010-07-09
IPC分类号： A61K9/10 , A61K9/00 , A61K38/13 , A61K39/00 , A61K31/573 , A61K31/445 , A61K39/395 , A61K31/685 , A61K31/355 , A61K9/14 , A61P37/06 , A61P29/00 , A61P27/02 , B82Y5/00
CPC分类号： A61K9/1274 , A61K9/0048 , C09K19/02
摘要： The eye is effectively treated by providing it with formulations including uncoated cationically charged microparticles of reversed cubic phase or reversed hexagonal phase material. The treatment methods are effective; for a variety of diseases and conditions including dry eye. The structure, charge and components of the microparticles in dispersion, with or without an active ingredient, provide mucoadhesion, layering, protection and prolonged duration of ophthalmic action.
摘要翻译： 通过向其提供具有反相立方相或反相六方相材料的未涂覆的带阳离子电荷的微粒的配方来有效地处理眼睛。 治疗方法有效; 用于各种疾病和病症，包括干眼症。 具有或不具有活性成分的分散体中的微粒的结构，电荷和组分提供粘膜粘附，分层，保护和延长眼科作用的持续时间。
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8.发明授权公开(公告)号：US09283177B2
公开(公告)日：2016-03-15
申请号：US12218624
申请日：2008-07-16
申请人： David M. Cohen , Eugene R. Cooper
发明人： David M. Cohen , Eugene R. Cooper
IPC分类号： A61K31/164 , A61K9/00 , A61K9/06 , A61K31/167 , A61K47/02 , A61K47/10 , A61K47/38
CPC分类号： A61K9/0019 , A61K9/06 , A61K31/164 , A61K31/167 , A61K47/02 , A61K47/10 , A61K47/38
摘要： The invention relates to a drug delivery system for the topical administration of anesthetic agents. For example, a topical anesthetic for rapid local anesthesia is provided. The topical anesthetic includes an anesthetic, volatile and non-volatile solvents, and an optional thickener. In addition, a method is taught for applying the topical anesthetic to the face of a patient without occlusion. The anesthetic is applied topically to an area for injection such that the dermatological procedure (cosmetic injections) can be performed in fifteen minutes.
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9.发明授权公开(公告)号：US08124057B2
公开(公告)日：2012-02-28
申请号：US12320431
申请日：2009-01-26
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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10.发明授权Bioadhesive nanoparticulate compositions having cationic surface stabilizers 有权具有阳离子表面稳定剂的生物粘附纳米颗粒组合物公开(公告)号：US07288267B2
公开(公告)日：2007-10-30
申请号：US10004808
申请日：2001-12-07
CPC分类号： A01N25/12 , A01N25/24 , A01N25/30 , A61K8/0241 , A61K8/36 , A61K8/416 , A61K8/49 , A61K8/553 , A61K8/63 , A61K8/73 , A61K8/731 , A61K8/8147 , A61K8/8182 , A61K9/113 , A61K9/145 , A61K9/146 , A61K2800/413 , A61K2800/612 , A61K2800/614 , A61Q5/00 , A61Q19/00 , B82Y5/00
摘要： Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.
摘要翻译： 描述了包含活性剂颗粒和一种或多种阳离子表面稳定剂的生物粘附纳米颗粒组合物。 阳离子表面稳定剂防止纳米颗粒聚集并增加纳米颗粒对生物底物（如昆虫，牙齿，骨骼，指甲，甲壳质，羽毛，鳞屑，粘液，皮肤，毛发，植物组织等）的生物粘附。 化学药剂，消费品（着色剂，调味剂或香料）或其他材料的药物活性化合物（例如，用于人或兽用药物的化合物），农药（农药，除草剂，肥料等） 通过与生物底物相互作用起作用。 此外，本发明涉及制备和使用这些生物粘附纳米颗粒组合物的方法。
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