公开(公告)号：US4452241A

公开(公告)日：1984-06-05

申请号：US383962

申请日：1982-06-01

申请人： Stanley J. Sarnoff ,  William R. Tarello ,  Claudio Lopez ,  Rudolph S. Malooley

发明人： Stanley J. Sarnoff ,  William R. Tarello ,  Claudio Lopez ,  Rudolph S. Malooley

IPC分类号： A61M15/00 ,  A61M16/00 ,  A62B7/04

CPC分类号： A61M15/009 ,  A61M16/00 ,  A61M2205/84

摘要： Apparatus for resuscitating a plurality of patients comprising four face mask assemblies each of which is operable to be operatively connected with a patient so as to permit fresh air to be supplied to the lungs of such patient and four bellows assemblies actuated by a cam track rotated either by a suitable clutched electric motor or by hand crank for delivering successive volumes of fresh air under pressure to each face mask assembly at a desired cyclical frequency wherein each cycle includes said fresh air delivery as a minor part thereof. Each face mask assembly has operatively associated therewith (1) a stale air exhaust valve assembly for permitting air expelled from the lungs of each patient during the remaining major part of each cycle associated therewith to be exhausted to atmosphere, (2) a medicament injector for selectively supplying a respiratory medicament dosage into the fresh air delivered to each face mask assembly, and (3) a pressure gauge for indicating the operative pressure adjacent the face mask assembly so as to enable the operator to readily determine a bronchoconstrictive condition of a patient operatively connected with the associated face mask assembly so that the associated selective medicament injector is selected to deliver medicament only during the minor cycle part when the fresh air is delivered.

摘要翻译： 用于复苏多个患者的装置，包括四个面罩组件，每个面罩组件可操作地与患者可操作地连接，以便允许将新鲜空气供应到该患者的肺部，以及由凸轮轨道驱动的四个波纹管组件， 通过合适的离合器电动机或手动曲柄，以期望的循环频率在压力下将连续体积的新鲜空气输送到每个面罩组件，其中每个循环包括作为其小部分的所述新鲜空气输送。 每个面罩组件与其可操作地相关联（1）陈旧的排气阀组件，用于在与其相关联的每个循环的剩余主要部分期间允许从每个患者的肺排出的空气排放到大气中;（2）药剂注射器， 选择性地向输送到每个面罩组件的新鲜空气中提供呼吸药物剂量，和（3）用于指示邻近面罩组件的操作压力的压力计，以使操作者能够容易地确定患者的支气管收缩状况 与相关联的面罩组件连接，使得相关联的选择性药剂注射器仅在新鲜空气输送时在次循环部分期间输送药物。

公开(公告)号：US4578064A

公开(公告)日：1986-03-25

申请号：US563768

申请日：1983-12-21

申请人： Stanley J. Sarnoff ,  George B. Calkins ,  William R. Tarello

发明人： Stanley J. Sarnoff ,  George B. Calkins ,  William R. Tarello

IPC分类号： A61M20060101 ,  A61M5/19 ,  A61M5/20 ,  A61M5/00

CPC分类号： A61M5/2066 ,  A61M5/2033 ,  A61M2005/206 ,  A61M5/19

摘要： A plural dosage automatic injector comprising an elongated tubular housing assembly having side by side first and second medicament injecting assemblies each including a container, a hypodermic needle, a liquid medicament and a plunger within the forward end portion thereof and, first and second stressed spring assemblies in the rearward end portion thereof disposed in operative relation with said first and second medicament injecting assemblies for operating the latter. A manually operable safety device is provided which includes a first safety pin operable (1) when in a safety position with respect to the first spring stressed assembly to prevent actuation and release thereof and (2) when removed from its safety position to permit the actuation and release of the second stressed spring assembly. A mechanical motion transmitting mechanism is provided which is operable to transmit a movement occurring as a result of the actuation and release of the first stressed spring assembly into a secondary actuating movement operable to (1) effect a relative movement between the automatic safety pin and the second stressed spring assembly sufficient to remove the automatic safety pin from its safety position and (2) thereafter actuate and release second stressed spring assembly to operate the second medicament injecting assembly.

摘要翻译： 一种多剂量自动注射器，包括：第一和第二药剂注射组件，其细长的管状壳体组件，每个包括容器，皮下注射针，液体药物和位于其前端部分内的柱塞;以及第一和第二应力弹簧组件 在其后端部分处于与所述第一和第二药剂注射组件操作的关系中，用于操作所述药剂注射组件。 提供了一种可手动操作的安全装置，其包括第一安全销，所述第一安全销在相对于所述第一弹簧应力组件处于安全位置时可操作（1），以防止其致动和释放;以及（2）当从其安全位置移除以允许致动 并释放第二个应力弹簧组件。 提供了一种机械运动传递机构，其可操作以将由第一应力弹簧组件的致动和释放的结果传递到辅助致动运动中，该辅助致动运动可操作以（1）实现自动安全销和第二应力弹簧组件之间的相对移动 第二应力弹簧组件足以将自动安全销从其安全位置移除，（2）此后致动并释放第二应力弹簧组件以操作第二药剂注射组件。

公开(公告)号：US4004577A

公开(公告)日：1977-01-25

申请号：US488434

申请日：1974-07-15

申请人： Stanley J. Sarnoff

发明人： Stanley J. Sarnoff

IPC分类号： A61B5/00 ,  A61B5/0404 ,  A61B5/04

CPC分类号： A61B5/411 ,  A61B5/0006 ,  A61B5/0404 ,  Y10S128/904

摘要： A method of treating coronary prone patients when heart attack symptoms occur before qualified direct contact personal care can be administered to the patient which comprises providing each of a multiplicity of coronary prone patients with (1) a plurality of separate medicaments in self-administering form and (2) a device operable when disposed in operative relation to a patient to provide auditory signals indicative of the existing heart beat conditions of the patient, establishing communication by telephone between the patients experiencing heart attack symptoms and a source capable of making a qualified response based upon the existing heart beat conditions of the patient as to the medicament which will be effective when administered, disposing the device in operative relation with the patient and communicating the signals to the qualified source by means of the communication, communicating by means of the communication a qualified response from the source an indicated medicament which should be administered based upon the existing heart beat conditions of the patient communicated to the source and administering said indicated medicament to said patient at a time prior to qualified direct contact personal care for the patient, the qualified source preferably includes a plurality of individuals available at all times at specific telephones having medical records of the patients immediately available, including standing orders of each patient's doctor, equipment for converting the auditory signals communicated to conventional oscilloscope pictures and electrocardiograms and outgoing telephones for notifying the patient's doctor and next-of-kin and for dispatching an ambulance to the patient.

摘要翻译： 一种治疗冠心病患者的方法，当可以向患者施用合格的直接接触个人护理之前发生心脏病发作症状时，其包括向多个冠状动脉易发患者提供（1）以自我管理形式的多种分开的药物，以及 （2）一种可操作的装置，其可操作性地与病人相关联以提供指示患者的现有心脏跳动状况的听觉信号，通过电话在经历心脏病发作症状的患者和能够作出合格响应的来源之间建立通信 在患者的现有心跳条件下，对于在施用时将有效的药物，将该装置与患者置于可操作的关系并且通过通信将信号传送到合格的来源，通过通信进行通信 来源的合格回应指示药物 应基于传达给源的患者的现有心跳条件来施用，并且在患者的合格直接接触个人护理之前的时间将所述指示的药物施用于所述患者，合格的来源优选包括多个个体可用 随时在特定电话上具有立即可用的病人的医疗记录，包括每个病人医生的常规命令，用于转换传达给常规示波器图像和心电图的听觉信号的设备，以及用于通知病人的医生和亲属的输出电话 并为病人派遣救护车。

公开(公告)号：US4795433A

公开(公告)日：1989-01-03

申请号：US176224

申请日：1988-03-31

申请人： Stanley J. Sarnoff

发明人： Stanley J. Sarnoff

IPC分类号： A61K31/415 ,  A61K47/18 ,  A61M5/19 ,  A61M5/20 ,  A61N1/36

CPC分类号： A61K9/0019 ,  A61K31/415 ,  A61K47/18 ,  A61M5/2066 ,  A61N1/327 ,  A61N1/36014 ,  A61M5/19

摘要： A method of treating a patient with liquid medicament under circumstances where intravenous injection is not practical but the fast response time of an intravenous injection is desirable, including the treatment of individuals undergoing heart attack symptoms with t-PA. The method comprises the steps of injecting the liquid medicament t-PA preferably with a blood absorption enhancing agent such as hydroxylamine hydrochloride into the muscle tissue of the patient, applying to the patient which has received the injection repeated blood flow stimulating cycles, each of which includes a period of electrical stimulus during which the muscle tissue which has received the injection tenses followed by a period of no electrical stimulus during which the muscle tissue which received the injection is allowed to relax inducing enhanced blood flow within the muscle tissue, and continuing the application of the repeated blood flow stimulating cycles until the injected liquid medicament has been sufficiently absorbed into the enhanced blood flow to achieve a desired possible patient response of reperfusion and apparatus for carrying out the method.

摘要翻译： 在静脉内注射不实际但需要静脉注射的快速反应时间的情况下，包括用t-PA治疗患有心脏病发作症状的个体的治疗患者的方法。 所述方法包括以下步骤：将液体药物t-PA优选用血液吸收增强剂如盐酸羟胺注射到患者的肌肉组织中，向已经接受注射重复的血液流动刺激循环的患者施用，其中每一个 包括一段时间的电刺激，在此期间接受注射时态的肌肉组织之后是没有电刺激的时期，在此期间允许接收注射的肌肉组织松弛，从而引起肌肉组织内增加的血液流动，并且继续 施加重复的血液流动刺激循环直到注射的液体药物已经被充分地吸收到增强的血液流中，以实现期望的可能的患者对再灌注的反应和用于实施该方法的装置。

公开(公告)号：US4656034A

公开(公告)日：1987-04-07

申请号：US735734

申请日：1985-05-20

申请人： Stanley J. Sarnoff

发明人： Stanley J. Sarnoff

IPC分类号： A61K31/66 ,  A61K38/44 ,  A61K37/50

CPC分类号： A61K31/66 ,  A61K38/446

摘要： The absorption of a scavenger of oxygen free radicals generated at the time of reperfusion or the absorption of an agent preventing the cytotoxic effects on healthy cells in a mammal. e.g. superoxide dismutase or S-aminotrimethyleneaminoethyl thiophosphate is enhanced by substantially simultaneously administering an absorption enhancing agent therefore, e.g. hydroxylamine or a non-toxic salt thereof. It is also part of the invention to inject WR-2721 intravenously or intramuscularly as a scavenger of oxygen free radicals even in the absence of an absorption enhancing agent.

摘要翻译： 在再灌注时产生的氧自由基清除剂的吸收或抑制哺乳动物对健康细胞的细胞毒性作用的药剂的吸收。 例如 超氧化物歧化酶或硫代磷酸S-氨基三亚甲基氨基乙酯通过基本上同时施用吸收增强剂而增强，因此，例如， 羟胺或其无毒盐。 即使在不存在吸收促进剂的情况下，也注射WR-2721作为氧自由基的清除剂而静脉内或肌内注射WR-2721的一部分。

公开(公告)号：US4661469A

公开(公告)日：1987-04-28

申请号：US708845

申请日：1985-03-06

申请人： Stanley J. Sarnoff

发明人： Stanley J. Sarnoff

IPC分类号： A61K31/13 ,  A61K31/415 ,  A61K31/66 ,  A61K33/02 ,  A61K38/38 ,  A61K38/43 ,  A61K38/44 ,  A61K38/49 ,  A61K47/18 ,  A61M5/19 ,  A61M5/20 ,  A61N1/36 ,  A61K31/00

CPC分类号： A61K31/66 ,  A61K31/13 ,  A61K31/415 ,  A61K33/02 ,  A61K38/49 ,  A61K47/18 ,  A61K9/0019 ,  C12Y304/21068

摘要： The absorption rate of t-PA in the blood is enhanced by administering it together with an absorption enhancing agent, preferably hydroxylamine or a salt thereof, most preferably hydroxylamine hydrochloride.

摘要翻译： 通过与吸收促进剂（优选羟胺或其盐，最优选盐酸羟胺）一起施用，血液中t-PA的吸收速率增强。

公开(公告)号：US4658830A

公开(公告)日：1987-04-21

申请号：US638695

申请日：1984-08-08

申请人： Stanley J. Sarnoff

发明人： Stanley J. Sarnoff

IPC分类号： A61K38/00 ,  A61K31/13 ,  A61K31/15 ,  A61K31/155 ,  A61K31/17 ,  A61K31/415 ,  A61K31/66 ,  A61K31/80 ,  A61K38/38 ,  A61K38/44 ,  A61K38/49 ,  A61K45/06 ,  A61K47/00 ,  A61K47/18 ,  A61M5/19 ,  A61M5/20 ,  A61N1/375 ,  A61B5/04

CPC分类号： A61K38/38 ,  A61K31/13 ,  A61K31/415 ,  A61K38/446 ,  A61K38/49 ,  A61K47/18 ,  A61K9/0019 ,  A61M5/2066 ,  A61M5/19

摘要： A device for initiating reperfusion treatment of a coronary prone individual prior to the establishment of qualified direct contact personal care at a time during the early minutes or hours after the onset of heart attack symptoms and after qualified personnel have participated by telephone in the decision to initiate such treatment. The device comprises an automatic injector assembly including a releasable force applying assembly, a safety normally disposed in a release preventing position movable therefrom into a release permitting position, a container or containers for separately containing a plurality of separate medicament dosages including a first dosage containing a clot selective coronary thrombolytic agent and a separate second dosage containing a cardiac antiarrhythmic agent and one or more hypodermic needles. The automatic injector is operable in response to a predetermined manual actuating procedure including the movement of the safety into its release permitting position for effecting release of the releasable force applying assembly and causing the released force to be applied so as to effect the movement of the hypodermic needle or needles into the muscle tissue of the individual and the flow of the separate medicament dosages outwardly from the container or containers through the hypodermic needle or needles into the muscle tissue of the individual.

摘要翻译： 在心脏病发作症状发作之前的早几分钟或几小时之前，在合格的直接接触个人护理建立之前，对冠心病患者进行再灌注治疗的装置，以及合格人员通过电话参与决定启动 这样的治疗。 该装置包括自动注射器组件，其包括可释放的施力组件，通常设置在其中可从其释放到释放允许位置的释放防止位置的安全性，用于分别容纳多个单独的药物剂量的容器或容器，所述容器或容器包括第一剂量， 凝块选择性冠状动脉血栓溶解剂和含有心脏抗心律不齐剂和一种或多种皮下注射针的单独的第二剂量。 自动注射器可操作以响应于预定的手动致动过程，包括将安全性移动到其释放允许位置以实现释放力施加组件的释放并且引起释放的力以施加皮下注射的运动 针或针进入个体的肌肉组织，并且单独药物的流动从容器或容器向外通过皮下注射针或针进入个体的肌肉组织。

公开(公告)号：US3938507A

公开(公告)日：1976-02-17

申请号：US411843

申请日：1973-11-01

申请人： Stanley J. Sarnoff ,  Herbert E. Reinhold, Jr. ,  Allan M. Wolfe

发明人： Stanley J. Sarnoff ,  Herbert E. Reinhold, Jr. ,  Allan M. Wolfe

IPC分类号： A61B5/00 ,  A61B5/0404 ,  A61B5/0464 ,  A61B5/04

CPC分类号： A61B5/0006 ,  A61B5/0404 ,  A61B5/0464 ,  Y10S128/901

摘要： A portable heart monitoring apparatus incorporating unique structural and functional features. Electrodes carried on the apparatus capture electrical signals representing the functioning of a heart beating therewithin and provides sensible output indications corresponding to predetermined characteristics of the electrical signals and, hence, of the detected heartbeat. One of the sensible outputs provided is the selective actuation of either of two logic lights indicating whether the heartbeat is above or below respectively a predetermined beating rate. The unit is automatically turned on by merely holding the instrument in the user's hand and the selective actuation of the various operational modes may be conveniently made by selectively placing one of the hands's digits (such as the thumb) from one touch contact point to another. Part of the operation in the test mode involves the effective testing of the reserve battery power without actually loading the battery. Structurally, the device is convenient to hold in the hand and includes, on one side, a ground plane for establishing electrical contact with the user's hand. The ground plane structure is also formed as an open-sided storage compartment for the electrodes and is surrounded by a wrap-around structure for self-storing of the electrode leads.

摘要翻译： 便携式心脏监测装置结合独特的结构和功能特征。 设备上携带的电极捕获表示心脏跳动功能的电信号，并提供对应于电信号的预定特性以及因此检测到的心跳的敏感的输出指示。 提供的一个明智的输出是两个逻辑灯中的任一个的选择性致动，指示心跳是否高于或低于预定的跳动速率。 通过仅将手持器保持在使用者的手中来自动地打开该单元，并且可以通过将一个手的数字（例如拇指）从一个触摸接触点选择性地放置到另一个来方便地进行各种操作模式的选择性致动。 在测试模式下的部分操作涉及对实际装载电池进行有效测试的备用电池电源。 在结构上，该装置方便地握在手中，并且在一侧包括用于与用户的手建立电接触的接地平面。 接地平面结构也形成为用于电极的开放式储存室，并且被用于电极引线的自存储的环绕结构包围。

公开(公告)号：US5002930A

公开(公告)日：1991-03-26

申请号：US19564

申请日：1987-02-27

申请人： Stanley J. Sarnoff ,  Burton E. Sobel

发明人： Stanley J. Sarnoff ,  Burton E. Sobel

IPC分类号： A61K31/13 ,  A61K31/415 ,  A61K31/66 ,  A61K33/02 ,  A61K38/38 ,  A61K38/43 ,  A61K38/44 ,  A61K38/49 ,  A61K47/18 ,  A61M5/19 ,  A61M5/20 ,  A61N1/36

CPC分类号： A61K31/66 ,  A61K31/13 ,  A61K31/415 ,  A61K33/02 ,  A61K38/49 ,  A61K47/18 ,  A61K9/0019 ,  C12Y304/21068

摘要： The absorption rate of proteins with medicinal properties in the blood is enhanced by administering the protein intramuscularly together with an absorption enhancing agent, e.g. hydroxylamine or a salt thereof.

摘要翻译： 通过与吸收促进剂肌内注射蛋白质来增强血液中具有药用性质的蛋白质的吸收速率，例如， 羟胺或其盐。

公开(公告)号：US4832682A

公开(公告)日：1989-05-23

申请号：US735311

申请日：1985-05-20

申请人： Stanley J. Sarnoff

发明人： Stanley J. Sarnoff

IPC分类号： A61K38/00 ,  A61K31/13 ,  A61K31/15 ,  A61K31/155 ,  A61K31/17 ,  A61K31/415 ,  A61K31/66 ,  A61K31/80 ,  A61K33/02 ,  A61K38/38 ,  A61K38/43 ,  A61K38/44 ,  A61K38/49 ,  A61K45/06 ,  A61K47/00 ,  A61K47/18 ,  A61M5/19 ,  A61M5/20 ,  A61N1/36 ,  A61N1/375

CPC分类号： A61K9/0019 ,  A61K31/13 ,  A61K31/415 ,  A61K31/66 ,  A61K33/02 ,  A61K38/446 ,  A61K38/49 ,  A61K47/18 ,  A61M5/2066 ,  A61N1/327 ,  A61N1/36017 ,  C12Y115/01001 ,  C12Y304/21068 ,  A61M2005/1787 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M5/19 ,  A61N1/3756

摘要： A method of treating a patient with liquid medicament under circumstances where intravenous injection is not practical but the fast response time of an intravenous injection is desirable, including the treatment of individuals undergoing heart attack symptoms with t-PA. The method comprises the steps of injecting the liquid medicament t-PA preferably with a blood absorption enhancing agent such as hydroxylamine hydrochloride into the muscle tissue of the patient, applying to the patient which has received the injection repeated blood flow stimulating cycles, each of which includes a period of electrical stimulus during which the muscle tissue which has received the injection tenses followed by a period of no electrical stimulus during which the muscle tissue which received the injection is allowed to relax inducing enhanced blood flow within the muscle tissue, and continuing the application of the repeated blood flow stimulating cycles until the injected liquid medicament has been sufficiently absorbed into the enhanced blood flow to achieve a desired possible patient response of reperfusion and apparatus for carrying out the method.

摘要翻译： 在静脉内注射不实际但需要静脉注射的快速反应时间的情况下，包括用t-PA治疗患有心脏病发作症状的个体的治疗患者的方法。 所述方法包括以下步骤：将液体药物t-PA优选用血液吸收增强剂如盐酸羟胺注射到患者的肌肉组织中，向已经接受注射重复的血液流动刺激循环的患者施用，其中每一个 包括一段时间的电刺激，在此期间接受注射时态的肌肉组织之后是没有电刺激的时期，在此期间允许接收注射的肌肉组织松弛，从而引起肌肉组织内增加的血液流动，并且继续 施加重复的血液流动刺激循环直到注射的液体药物已经被充分地吸收到增强的血液流中，以实现期望的可能的患者对再灌注的反应和用于实施该方法的装置。