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1.发明授权Autoinjector converted from intramuscular to subcutaneous mode of injection 失效从INTRAMUSCULAR转换为注射模式的自动注射器
公开(公告)号：US5102393A
公开(公告)日：1992-04-07
申请号：US380451
申请日：1989-07-17
申请人： Stanley J. Sarnoff , Claudio Lopez
发明人： Stanley J. Sarnoff , Claudio Lopez
CPC分类号： A61M5/2033 , A61M2005/206 , A61M2005/2073 , A61M5/24
摘要： An autoinjector converted from an intramuscular to a subcutaneous mode of injection comprising a housing having a medicament cartridge assembly mounted within the housing means in a storage position for movement out of the storage position and a releasable stressed spring assembly for moving the medicament cartridge assembly means out of the storage position. The stressed spring assembly is operable in response to a manual actuating procedure which does not require compression of the subcutaneous tissue to effect an intramuscular mode of injection by moving the hypodermic needle of the cartridge assembly outwardly of the housing into the muscle tissue at the injection site of a user and a major portion of the liquid medicament of the cartridge assembly outwardly through the hypodermic needle into the muscle tissue of the user. An injection mode converting structure is secured in a subcutaneous mode position for converting the mode of injection effected by the stressed spring assembly from the intramuscular mode of injection to a subcutaneous mode of injection in which the needle cannot extend substantially beyond subcutaneous tissue at the injection site of the user and a major portion of the liquid medicament enters into the subcutaneous tissue.
摘要翻译： 一种自动注射器，其从肌肉内注射到皮下注射模式，包括壳体，所述壳体具有安装在所述壳体装置内的药剂盒组件，所述药剂盒组件位于所述存储位置内的存储位置，以及用于将所述药剂盒组件装置移出的释放应力弹簧组件 的仓位。 应力弹簧组件可操作以响应于手动致动程序，其不需要压缩皮下组织以通过将套筒组件的皮下注射针移动到注射部位的肌肉组织内，从而实现肌内注射模式 使用者和药筒组件的液体药物的主要部分通过皮下注射针向外进入使用者的肌肉组织。 注射模式转换结构固定在皮下模式位置，用于将由应力弹簧组件实现的注射模式从肌内注射模式转换为皮下注射模式，其中针不能在注射部位基本上延伸超过皮下组织 并且液体药物的主要部分进入皮下组织。
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2.发明授权Disposable hypodermic syringe with plastic snap-on needle hub and heat shrink seal therefor 失效一次性皮下注射器，带塑料扣式针座和热收缩密封
公开(公告)号：US4747839A
公开(公告)日：1988-05-31
申请号：US942727
申请日：1986-12-17
申请人： William R. Tarello , Claudio Lopez
发明人： William R. Tarello , Claudio Lopez
CPC分类号： A61M5/3202 , A61M5/286 , Y10S128/18
摘要： A disposable hypodermic syringe having a cylindrical barrel open at both its forward and rearward ends, with the forward tooled end having a necked down portion terminating in an annular flange having an outer diameter greater than that of the necked down portion and less than that of the cylindrical barrel, a stopper positioned in the necked down portion of the cylindrical barrel to seal off the tooled end of the barrel, a resilient plastic needle hub assembly fitted on the forward end of the cylindrical barrel. The hub assembly including a cylindrical body having both a forward and a rearward end, a nose portion extending forwardly from the forward end of the cylindrical body, a needle affixed to the nose portion away from the forward end of the cylindrical body, the cylindrical body being sized whereby it will resiliently fit over and engage the annular flange of the necked down portion of the cylindrical barrel to operatively retain the needle hub assembly on the cylindrical barrel with a sleeve of heat shrinkable plastic fitted over a portion of the hub assembly and contiguous cylindrical barrel whereby when heat is applied the sleeve will shrink to firmly engage the aforedescribed syringe portions and thereby provide an air tight seal between the hub body and the cylindrical barrel and in addition whereby the shrink tension will cause the hub body to more firmly engage the annular flange.
摘要翻译： 一次性皮下注射器，其具有在其前端和后端两端都开口的圆柱形筒，其前向工具端具有终止于外径大于颈缩部的外径的颈缩部，并且小于 圆柱形筒，位于圆柱形筒的颈缩部分中的塞子，用于密封筒的工具端部，弹性塑料针座组件，其装配在圆柱形筒的前端上。 所述轮毂组件包括具有前端和后端的圆柱体，从所述圆柱体的前端向前延伸的鼻部，与所述圆柱体的前端相对地延伸到所述鼻部的针，所述圆柱体 其尺寸使得其将弹性地配合在圆柱形筒的颈缩部分的环形凸缘上并且接合圆柱形筒的颈缩部分的环形凸缘，以将针座组件可操作地保持在圆柱形筒上，该套筒具有装配在轮毂组件的一部分上的热收缩塑料套筒， 圆柱形筒，由此当施加热量时，套筒将收缩以牢固地接合上述注射器部分，从而在轮毂本体和圆柱形筒之间提供气密密封，此外，收缩张力将使轮毂体更牢固地接合 环形法兰
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3.发明授权
公开(公告)号：US4518384A
公开(公告)日：1985-05-21
申请号：US505323
申请日：1983-06-17
CPC分类号： F41A9/84 , A61M5/20 , A61M5/24 , F41B11/85 , A61M2005/005 , A61M2005/206 , A61M2005/2414 , A61M2205/0266 , A61M5/2053 , A61M5/2425
摘要： A medicament discharging device and an expendable clip thereon containing a plurality of medicament cartridges. Each of the cartridges comprises a container, a dosage of medicament in the container, a hypodermic needle sealingly contained in a sterile condition in cooperating relation with the container and a movable wall means at one end of the container operable when moved through a discharging stroke to cause the sharpened end of the needle to move outwardly out of sealingly contained relation and into the muscle tissue of a patient and the medicament dosage to move outwardly of the container into the opposite end of the needle and out of the sharpened end thereof into the muscle tissue of the patient. The medicament discharging device comprises a portable manually engageable housing structure defining a medicament cartridge receiving station, a plunger mounted in the housing structure for movement through the medicament cartridge receiving station in repetitive operative cycles each of which includes a discharging stroke in one direction and a return stroke in the opposite direction, a manually actuatable mechanism for effecting movement of the plunger through an operative cycle, and a releasable connection between the housing structure and the clip for securing the same in operative relation so that successive cartridges in the clip will be presented in the medicament cartridge receiving station of the housing structure for injection in response to an operative cycle.
摘要翻译： 一种药物排出装置和一个包含多个药剂盒的消耗性夹子。 每个药筒包括容器，容器中药物的剂量，密封地容纳在与容器配合关系的无菌状态下的皮下注射针，以及在容器的一端可移动的壁装置，其在移动通过排出冲程时可操作 导致针尖的尖端从密封容纳的关系向外移动到患者的肌肉组织中，并且药物剂量从容器的外部移动到针的相对端并从其尖锐的末端进入肌肉 病人的组织。 药物排放装置包括限定药剂盒接收站的便携式手动接合壳体结构，安装在壳体结构中的柱塞，用于以重复的操作循环移动通过药剂盒接收站，每个循环包括在一个方向上的排出冲程和返回 相反方向的行程，用于实现柱塞通过操作循环的运动的手动致动机构，以及壳体结构和夹子之间的可释放连接，用于将其固定在可操作的关系中，使得夹具中的连续的盒将呈现在 用于响应于操作循环的用于注射的壳体结构的药物盒接收台。
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公开(公告)号：US4329988A
公开(公告)日：1982-05-18
申请号：US219488
申请日：1980-12-23
申请人： Stanley J. Sarnoff , Claudio Lopez
发明人： Stanley J. Sarnoff , Claudio Lopez
CPC分类号： A61M5/2033 , A61M5/2066 , A61M5/002 , A61M5/19
摘要： A plural injection assembly comprising a plurality of separate injections capable of separate actuation and a holder for stably supporting the separate injectors together and for manually facilitating the sequential actuation thereof.
摘要翻译： 多个注射组件，包括能够分离致动的多个分离的注射和用于稳定地将分离的注射器支撑在一起并用于手动促进其顺序致动的保持器。
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公开(公告)号：US5658259A
公开(公告)日：1997-08-19
申请号：US545149
申请日：1995-10-19
申请人： William R. Pearson , David Edward Spady , Claudio Lopez , Hyung J. Lee , John G. Wilmot , N. Lawrence Dalling
发明人： William R. Pearson , David Edward Spady , Claudio Lopez , Hyung J. Lee , John G. Wilmot , N. Lawrence Dalling
CPC分类号： A61M5/24 , A61M5/2033 , A61M5/326 , A61M2005/206 , A61M2005/2073 , A61M2005/247 , A61M2005/31516 , A61M2005/3247 , A61M2005/3267 , A61M5/3202
摘要： An injection device includes a generally tubular outer body and a medicament cartridge assembly carried within the outer body. The cartridge assembly includes a glass container, a charge of medicament disposed within the glass container, iii) a plunger member rearwardly confining the medicament, and iv) a seal for sealing the forward portion of the glass container. A needle has a rearward end disposed proximate the seal, with the seal and needle being movable with respect to one another. A rigid needle cover member is normally maintained in an inoperative position and is movable relative to said body to a protective position wherein the needle cover member extends forwardly to cover the forward end of the needle. A releasable spring is releasable in response to a predetermined actuating procedure to drive a collet member forwardly within the outer body and thereby enable i) the cartridge assembly to move relative to the needle so that the rearward end of the needle pierces the seal to establish communication with the medicament, ii) the needle to move with respect to the body so that the needle projects outwardly from the forward end of the body, and iii) the needle cover to move relative to the body from the inoperative position to the protective position so that the needle cover member extends beyond the forward end of the needle.
摘要翻译： 注射装置包括大致管状的外部主体和在外部本体内承载的药物盒组件。 盒组件包括玻璃容器，设置在玻璃容器内的药物装料，iii）向后限制药物的柱塞件，以及iv）用于密封玻璃容器前部的密封件。 针具有靠近密封件设置的后端，密封件和针可相对于彼此移动。 刚性针盖构件通常保持在不工作位置并且可相对于所述主体移动到保护位置，其中针盖构件向前延伸以覆盖针的前端。 可释放的弹簧响应于预定的致动过程而可释放，以在筒体内向前驱动夹头构件，从而能够使盒组件相对于针移动，使得针的后端刺穿密封件以建立通信 与药物相连，ii）针相对于身体移动，使得针从身体的前端向外突出，以及iii）针罩相对于身体从不工作位置移动到保护位置，因此 针盖构件延伸超过针的前端。
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6.发明授权
公开(公告)号：US5085641A
公开(公告)日：1992-02-04
申请号：US507795
申请日：1990-04-12
CPC分类号： A61M5/2033 , A61M2005/206
摘要： A stressed spring assembly for providing an operative stroke in cooperating relation with a medicament cartridge assembly of an auto-injector so as to inject a liquid medicament of the medicament cartridge assembly through a hypodermic needle of the medicament cartridge assembly into an injection site of the user. The stressed spring assembly includes a cap structure serving the plural purposes of (1) facilitating the securement of the cap structure and remainder of the auto-injection with the user's pocket, (2) alleviating the likelihood of an unwanted release of the releasable mechanism of the stressed spring assembly with a resultant unwanted movement of the hypodermic needle and an unwanted movement of the liquid medicament outwardly of the hypodermic needle by requiring two different manual movements for its removal, and (3) protecting against an unwanted contact with the hypodermic needle while in extended operative position after withdrawal from the injection site. The cap structure is formed of first and second members disposed in a fixed assembled position with respect to one another into which the first and second members are snap-fitted by a relative movement toward one another in an axial direction. Both members are of a configuration enabling them to be molded by corresponding die surfaces contained on two die members movable together and apart.
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公开(公告)号：US4755169A
公开(公告)日：1988-07-05
申请号：US943135
申请日：1986-12-18
CPC分类号： A61M5/2066 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/31598 , A61M5/19 , A61M5/2448
摘要： An automatic injector apparatus comprising an outer housing assembly, a hypodermic needle, first and second containers, a first liquid medicament ingredient in the first container and a second medicament ingredient in the second container, first and second pistons in the first and second containers respectively, a releasable stressed spring arrangement capable of being released twice, once for movement through a first piston moving stroke and second through a second piston moving stroke, a first releasing device operable in response to a first predetermined actuating procedure for accomplishing a first release of the spring arrangement so as to effect movement of the first piston through a liquid medicament ingredient moving stroke causing the liquid medicament ingredient to mix with the medicament ingredient in the second container to form liquid medicament and a second releasing device operable in response to a second actuating procedure for accomplishing a second release of the spring arrangement so as to effect movement of the second piston through an operative stroke causing the hypodermic needle to be moved into the muscle tissue of the patient and the liquid medicament to be moved through the needle into the muscle tissue of the patient.
摘要翻译： 一种自动注射器装置，包括外壳体组件，皮下注射针，第一和第二容器，第一容器中的第一液体药物成分和第二容器中的第二药物成分，第一和第二容器中的第一和第二活塞， 可释放的应力弹簧装置，其能够被释放两次，一次用于通过第一活塞移动行程运动，第二通过第二活塞运动行程;第一释放装置，可响应于第一预定的致动程序来完成弹簧的第一释放 以便通过液体药物成分移动行程来实现第一活塞的运动，使得液体药物成分与第二容器中的药物成分混合形成液体药物，第二释放装置可响应于第二致动程序而操作， 完成spri的第二次释放 以便实现第二活塞通过操作行程的移动，使得皮下注射针被移动到患者的肌肉组织中，并且液体药物通过针移动到患者的肌肉组织中。
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公开(公告)号：US4723937A
公开(公告)日：1988-02-09
申请号：US735740
申请日：1985-05-20
申请人： Stanley J. Sarnoff , Claudio Lopez
发明人： Stanley J. Sarnoff , Claudio Lopez
CPC分类号： A61M5/2066 , A61M2005/1787 , A61M2005/206
摘要： An automatic injecting device including an elongated housing assembly, a stressed spring assembly mounted within the housing assembly so as to be released in response to a predetermined manual acutation procedure, and a medicament cartridge assembly mounted within the housing assembly in cooperating relation with the stressed spring assembly comprising a hypodermic needle and a medicament container housing forward and rearward individual dosages of different relatively incompatible liquid medicaments mounted therein and separated by a deformable stopper. The medicament container is formed of glass and includes a cylindrical wall open at its rearward end and having an exteriorly flanged necked down forward end portion. A hub assembly connects the exteriorly flanged necked down forward end portion with the hypodermic needle. A separate fitment of molded plastic material is mounted within the interior of the cylindrical glass wall adjacent the necked down forward end portion thereof for radially inwardly deforming the stopper during operation and thereby providing an axial by-pass in the periphery thereof.
摘要翻译： 一种自动注射装置，包括细长的壳体组件，应力弹簧组件，其安装在所述壳体组件内以便响应于预定的手动积分程序被释放;以及药剂盒组件，其与所述应力弹簧协作关系地安装在所述壳体组件内 组合物包括皮下注射针和药物容器，其容纳安装在其中并由可变形塞子分隔开的不同相对不相容的液体药物的前后单独剂量。 药物容器由玻璃形成，并且包括在其后端开口并具有外部凸缘颈缩的前端部的圆柱形壁。 轮毂组件将外部带凸缘的颈缩前端部分与皮下注射针连接。 模制塑料材料的单独配件安装在邻近颈缩的前端部的圆柱形玻璃壁的内部，用于在操作期间使止动件径向向内变形，从而在其周边中提供轴向旁路。
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公开(公告)号：US4689042A
公开(公告)日：1987-08-25
申请号：US735995
申请日：1985-05-20
CPC分类号： A61M5/2066 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/31598 , A61M5/19 , A61M5/2448
摘要： An automatic injector apparatus comprising an outer housing assembly, a hypodermic needle, first and second containers, a first liquid medicament ingredient in the first container and a second medicament ingredient in the second container, first and second pistons in the first and second containers respectively, a releasable stressed spring arrangement capable of being released twice, once for movement through a first piston moving stroke and second through a second piston moving stroke, a first releasing device operable in response to a first predetermined actuating procedure for accomplishing a first release of the spring arrangement so as to effect movement of the first piston through a liquid medicament ingredient moving stroke causing the liquid medicament ingredient to mix with the medicament ingredient in the second container to form liquid medicament and a second releasing device operable in response to a second actuating procedure for accomplishing a second release of the spring arrangement so as to effect movement of the second piston through an operative stroke causing the hypodermic needle to be moved into the muscle tissue of the patient and the liquid medicament to be moved through the needle into the muscle tissue of the patient.
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公开(公告)号：US4452241A
公开(公告)日：1984-06-05
申请号：US383962
申请日：1982-06-01
CPC分类号： A61M15/009 , A61M16/00 , A61M2205/84
摘要： Apparatus for resuscitating a plurality of patients comprising four face mask assemblies each of which is operable to be operatively connected with a patient so as to permit fresh air to be supplied to the lungs of such patient and four bellows assemblies actuated by a cam track rotated either by a suitable clutched electric motor or by hand crank for delivering successive volumes of fresh air under pressure to each face mask assembly at a desired cyclical frequency wherein each cycle includes said fresh air delivery as a minor part thereof. Each face mask assembly has operatively associated therewith (1) a stale air exhaust valve assembly for permitting air expelled from the lungs of each patient during the remaining major part of each cycle associated therewith to be exhausted to atmosphere, (2) a medicament injector for selectively supplying a respiratory medicament dosage into the fresh air delivered to each face mask assembly, and (3) a pressure gauge for indicating the operative pressure adjacent the face mask assembly so as to enable the operator to readily determine a bronchoconstrictive condition of a patient operatively connected with the associated face mask assembly so that the associated selective medicament injector is selected to deliver medicament only during the minor cycle part when the fresh air is delivered.
摘要翻译： 用于复苏多个患者的装置，包括四个面罩组件，每个面罩组件可操作地与患者可操作地连接，以便允许将新鲜空气供应到该患者的肺部，以及由凸轮轨道驱动的四个波纹管组件， 通过合适的离合器电动机或手动曲柄，以期望的循环频率在压力下将连续体积的新鲜空气输送到每个面罩组件，其中每个循环包括作为其小部分的所述新鲜空气输送。 每个面罩组件与其可操作地相关联（1）陈旧的排气阀组件，用于在与其相关联的每个循环的剩余主要部分期间允许从每个患者的肺排出的空气排放到大气中;（2）药剂注射器， 选择性地向输送到每个面罩组件的新鲜空气中提供呼吸药物剂量，和（3）用于指示邻近面罩组件的操作压力的压力计，以使操作者能够容易地确定患者的支气管收缩状况 与相关联的面罩组件连接，使得相关联的选择性药剂注射器仅在新鲜空气输送时在次循环部分期间输送药物。
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