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公开(公告)号：US6165155A
公开(公告)日：2000-12-26
申请号：US232579
申请日：1999-01-16
IPC分类号： A61M5/142 , A61M5/20 , A61M5/24 , A61M5/28 , A61M5/30 , A61M5/31 , A61M5/315 , A61M5/32 , A61M5/34 , A61N1/30
CPC分类号： A61N1/30 , A61M5/14248 , A61M5/19 , A61M5/2046 , A61M5/2066 , A61M5/2425 , A61M5/282 , A61M5/286 , A61M5/30 , A61M5/31568 , A61M5/3232 , A61M2005/14252 , A61M2005/3022 , A61M2005/3123 , A61M2005/3128 , A61M2005/341 , A61M2205/50 , A61M2205/581 , A61M2205/583 , G06F19/00
摘要： A low-profile multipathway automatic drug delivery system utilizing a battery powered control pad coupled to a disposable drug storage and delivery system and strapped to a patient's limb or torso. A preprogrammed or on-demand drug administration sequence is input to the control pad. When a drug is to be administered, the control pad ignites a high energy density propellant charge in the drug delivery system. Expanding propellant gas exerts pressure on a drug in a second chamber and forces it from the storage reservoir. Depending upon the type of drug delivery system required for the drug being administered, the propellant will either: (i) force a hypodermic needle into a patient's muscle tissue, propel the drug in the storage container into the needle embedded in the patient, and withdraw the needle; (ii) force the drug from the storage container through a jet nozzle where the drug is injected into subcutaneous tissue; (iii) force the drug from the storage container into a patch for passive transdermal delivery; (iv) force the drug into a patch for iontophoretic transdermal diffusion; or (v) force together two drugs stored separately that are unstable when mixed, and then administer them through one of the methods described in steps (i) to (iv).
摘要翻译： 一种低调的多路径自动药物递送系统，其利用电池供电的控制垫，其耦合到一次性药物储存和递送系统并且绑扎到患者的肢体或躯干上。 将预编程或按需药物管理序列输入到控制垫。 当要施用药物时，控制垫点燃药物递送系统中的高能量密度推进剂装药。 扩展的推进剂气体对第二室中的药物施加压力并将其从储存容器中迫使。 取决于给药药物所需的药物递送系统的类型，推进剂将：（i）将皮下注射针刺入患者的肌肉组织，推动储存容器中的药物进入嵌入患者体内的针头，然后取出 针 （ii）将药物从储存容器中通过喷嘴喷射，药物注射到皮下组织中; （iii）将药物从储存容器中压入补片以进行被动透皮递送; （iv）强迫药物进入离子电渗透皮扩散贴片; 或（v）将混合时不稳定的两种药物分开一起，然后通过步骤（i）至（iv）中描述的方法之一进行管理。
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公开(公告)号：US5087242A
公开(公告)日：1992-02-11
申请号：US383939
申请日：1989-07-21
CPC分类号： A61N1/0436
摘要： A hydratable iontophoretic bioelectrode includes a layer of material for absorbing and holding an ionized fluid when placed in contact with the fluid. A conductive sheet of material is positioned in contact with one side of the layer of material and is connectable to an electrical charged source to receive a charge of the same polarity as the polarity of ions in the fluid. A support base holds the layer of material and conductive sheets in place to enable placement of the layer of material against the skin or tissue of a person into which ions from the ionized fluid are to be delivered. This is carried out by applying the charge in question to the conductive sheet to cause the ions in the layer of material to migrate therefrom into the person's skin or tissue.
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公开(公告)号：US5037380A
公开(公告)日：1991-08-06
申请号：US572477
申请日：1990-08-23
CPC分类号： A61N1/0448
摘要： An iontophoretic bioelectrode includes a pouch for holding a solution, a receptacle element disposed in a wall of the pouch to allow communication therethrough from the exterior to the interior of the pouch, a pair of elongate, generally parallel prongs joined at one end and dimensioned to allow insertion thereof through the receptacle element into the interior of the container, and a solution absorbing material disposed between the prongs to absorb solution with which it makes contact.
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14.发明授权Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange 失效用于通过离子交换在受控ph中应用药物的离子电渗疗法的方法和装置
公开(公告)号：US4915685A
公开(公告)日：1990-04-10
申请号：US64769
申请日：1987-06-19
IPC分类号： A61N1/30
CPC分类号： A61N1/0432 , A61N1/0448
摘要： Methods and apparatus for administering known quantities of medicaments by iontophoresis, while avoiding burns caused by extremes in the pH of the medicament medium during passage of an electric current, are disclosed. It is known that as iontophoresis progresses in conventional iontophoresis systems, the electrolysis of water occurs to produce hydrogen or hydroxyl ions at the interface of the electrode and medicament medium. Since these ions are highly mobile, they are transported directly into the skin of a patient in preference to the larger medicament ions. Thus, extreme changes in pH are experienced which result in burns due to the acidificaion or alkalinization of the medicament medium and passage of electric current through the skin. In addition, the efficiency of iontophoresis decreases over time. The present invention avoids extremes in pH by removing the hydrogen or hydroxyl ions which are created during iontophoresis and creates conditions for constant delivery over prolonged periods of time.In the present invention, the medicament ions are attached to an ion exchange matrix, such as an ion exchange resin. When the medicament leaves the ion exchange matrix, the vacated active site is filled by the produced electrolysis products, thereby allowing iontophoresis to progress at a relatively constant pH.
摘要翻译： 公开了通过离子电渗法施用已知量的药物的方法和装置，同时避免了在电流通过过程中由药物介质的pH极端引起的烧伤。 众所周知，在常规离子电渗系统中离子电渗进行时，发生电解水以在电极和药物介质的界面产生氢或羟基离子。 由于这些离子是高度移动的，所以它们优先于较大的药物离子直接转运到患者的皮肤中。 因此，经历了pH的极端变化，其由于药物介质的酸化或碱化以及电流通过皮肤而导致燃烧。 此外，离子电渗疗法的效率随时间而降低。 本发明通过除去在离子电渗疗法期间产生的氢或羟基离子来避免pH值的极端，并且产生在长时间内恒定输送的条件。 在本发明中，药物离子连接到离子交换基质如离子交换树脂上。 当药物离开离子交换基质时，所产生的电解产物填充空位的活性位点，从而允许离子电渗在相对恒定的pH下进行。
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公开(公告)号：US08191421B2
公开(公告)日：2012-06-05
申请号：US12266144
申请日：2008-11-06
IPC分类号： G01H1/00
CPC分类号： F41H1/04 , F41H1/02 , G01D21/00 , G01L5/0052 , G01L5/14
摘要： Methods and devices for a miniature, ultra-low power impact recorder for detecting, quantifying and recording the energy of an explosive blast or ballistic projectile impact. In one embodiment, the impact recorder can included a sensor comprised of an array of electromechanical resonators that is sensitive to the vibrations produced in selected, discrete frequency ranges that approximate the spectral signature characteristics of the shockwave resulting from the ballistic impact event, even after traveling through impacted material or body tissues.
摘要翻译： 用于检测，量化和记录爆炸性爆炸或弹道射弹冲击能量的微型超低功率冲击记录仪的方法和装置。 在一个实施例中，冲击记录器可以包括传感器，该传感器包括机电谐振器阵列，其对于在选定的离散频率范围内产生的振动敏感，所述离散频率范围近似于由弹道撞击事件引起的冲击波的频谱特征特征，即使在旅行 通过冲击材料或身体组织。
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公开(公告)号：US08056391B2
公开(公告)日：2011-11-15
申请号：US12116605
申请日：2008-05-07
IPC分类号： G01L5/00
CPC分类号： G01P1/127 , A42B3/046 , F41H1/02 , F41H1/04 , F41J5/056 , G01L5/0052 , G01P15/04 , G01P15/0891 , G01P15/0922
摘要： Methods and devices for a miniature, ultra-low power impact recorder for detecting, quantifying and recording the energy of an explosive blast or ballistic projectile impact. In one embodiment, the impact recorder can included a sensor comprised of an array of electromechanical resonators that is sensitive to the vibrations produced in selected, discrete frequency ranges that approximate the spectral signature characteristics of the shockwave resulting from the ballistic impact event, even after traveling through impacted material or body tissues.
摘要翻译： 用于检测，量化和记录爆炸性爆炸或弹道射弹冲击能量的微型超低功率冲击记录仪的方法和装置。 在一个实施例中，冲击记录器可以包括传感器，其包括机电谐振器的阵列，其对于在选定的离散频率范围内产生的振动敏感，所述离散频率范围近似于由弹道撞击事件引起的冲击波的频谱特征特征，即使在旅行 通过冲击材料或身体组织。
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公开(公告)号：US6086562A
公开(公告)日：2000-07-11
申请号：US165164
申请日：1998-10-01
IPC分类号： A61M5/142 , A61M5/20 , A61M5/24 , A61M5/28 , A61M5/30 , A61M5/31 , A61M5/315 , A61M5/32 , A61M5/34 , A61N1/30
CPC分类号： A61M5/282 , A61M5/14248 , A61M5/2046 , A61N1/30 , A61M2005/14252 , A61M2005/206 , A61M2005/3022 , A61M2005/3123 , A61M2005/3128 , A61M2005/341 , A61M2205/583 , A61M5/2066 , A61M5/286 , A61M5/3234
摘要： An automatic injection device includes a drug-filled vessel having a flexible membrane over a first opening thereof and a puncturable seal in a wall thereof, a hollow needle attached at a first end to the flexible membrane and having a sharp end positioned proximate the puncturable seal housing. A pressure source such as a combustible propellant provides a compressed gas above the flexible membrane to force the membrane into the drug-filled vessel, forcing the hollow needle through the puncturable seal and the drug contained in the vessel through the hollow needle. After the drug has been substantially evacuated from the vessel, the membrane is allowed to return to its pre-expanded state thus retracting the hollow needle into the vessel. Preferably, the flexible membrane is an elastomeric material having a plurality of concentrically configured corrugations to allow expansion of the membrane into the vessel. The inner surface of the vessel may have a dome-like shape such that expansion of the membrane into the vessel substantially matches the dome-like shape and thus forces substantially the entire amount of the drug from the vessel.
摘要翻译： 自动注射装置包括在其第一开口上具有柔性膜的药物填充容器和在其壁中的可刺破的密封件，中空针头在第一端附接到柔性膜并且具有靠近可穿刺密封件定位的尖端 住房。 诸如可燃推进剂的压力源在柔性膜之上提供压缩气体，以迫使膜进入药物填充的容器，迫使空心针穿过可穿刺的密封和通过中空针头容纳在容器中的药物。 在药物已经从血管基本上排出之后，允许膜返回到其预扩张状态，从而将中空针缩回到容器中。 优选地，柔性膜是具有多个同心配置的波纹的弹性体材料，以允许膜膨胀到容器中。 容器的内表面可以具有圆顶形状，使得膜进入容器的膨胀基本上与圆顶状形状匹配，因此迫使药物从容器的基本上全部量。
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公开(公告)号：US5281287A
公开(公告)日：1994-01-25
申请号：US31260
申请日：1993-03-12
CPC分类号： A61N1/0436 , A61N1/0468 , Y10T156/1052
摘要： A hydratable iontophoretic bioelectrode includes a plurality of layers of material capable of absorbing and holding an ionized fluid when placed in contact with the fluid. Adjacent layers are maintained at least partially out of contact from one another by disposition between the layers of spacing elements such as sugar or other dissolvable particles or cellulose. The edges of the layers may be crimped to maintain the layers in a stack for assembly with an electrode sheet; such a sheet would be provided for receiving an electrical current to thereby produce an electric field and cause a migration of ions of the ionized fluid away from the electrode sheet and into the skin or tissue of a person or animal against which the bioelectrode is placed.
摘要翻译： 可水合的离子电渗生物电极包括多个能够在与流体接触放置时吸收和保持电离流体的材料层。 相邻的层通过在诸如糖或其它可溶性颗粒或纤维素之间的间隔元件层之间的配置而至少部分地彼此不接触。 层的边缘可以被压接以将层保持在堆叠中以与电极片组装; 这样的片材将被提供用于接收电流从而产生电场并使离子化流体的离子迁移离开电极片并进入放置生物电极的人或动物的皮肤或组织。
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公开(公告)号：US5248295A
公开(公告)日：1993-09-28
申请号：US703456
申请日：1991-05-21
CPC分类号： A61N1/044 , A61N1/0436
摘要： An iontophoretic bioelectrode includes an enclosure forming upper sheet of material having a generally planar outer section circumscribing a raised central section which defines an interior compartment. A compliant, resilient and sticky raised barrier is formed on the underside of the outer section of the upper sheet of material to circumscribe the central section. When placed against the skin of a person, the barrier adheres to the skin to form a seal completely around the central section and interior compartment into which an ion carrying solution may then be introduced for administration, by iontophoresis, into a persons' skin.
摘要翻译： 离子电渗生物电极包括形成上片材料的外壳，其具有围绕限定内部隔间的凸起中心部分的大致平坦的外部部分。 在上部材料的外部部分的下侧上形成柔顺且弹性和粘性的凸起的隔离物以包围中心部分。 当放置在人的皮肤上时，屏障粘附到皮肤上，以便在中心部分和内部隔室周围完全形成密封，然后可以通过离子电渗法将离子载体溶液引入其中，以通过离子电渗法进入人的皮肤。
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20.发明授权Method of iontophoretically treating acne, furuncles and like skin disorders 失效离子电渗治疗痤疮，fur疮等皮肤疾病的方法
公开(公告)号：US4979938A
公开(公告)日：1990-12-25
申请号：US350227
申请日：1989-05-11
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A method is disclosed for treating acne, boils and similar skin disorders which are characterized by closed, blocked channels in the epidermis of the skin. The method comprises applying an applicator electrode on the skin of the person to be treated; providing a relatively small amount of water containing dissolved ions in contact with the applicator electrode and the affected tissue; applying a dispersive electrode on the skin of the person to be treated; applying a voltage differential to the applicator and dispersive electrodes such that the applicator electrode has a negative charge and the dispersive electrode has a positive charge; producing hydroxyl ions at the applicator electrode to develop a strongly alkaline solution therein, and driving the ions down the channels of the affected tissue by iontophoresis; continuing the application of the voltage differential to the applicator and dispersive electrodes for a time sufficient to disrupt the blockage of the channels in the affected tissue and to establish drainage from the channels.
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