公开(公告)号：US20070060988A1

公开(公告)日：2007-03-15

申请号：US11541308

申请日：2006-09-29

申请人： Stephen Grenon ,  Omer Barrier ,  David Foshee ,  Donald Korb ,  Timothy Willis

发明人： Stephen Grenon ,  Omer Barrier ,  David Foshee ,  Donald Korb ,  Timothy Willis

IPC分类号： A61F7/00

CPC分类号： A61H7/001 ,  A61B18/12 ,  A61B2018/046 ,  A61B2018/048 ,  A61F9/00 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61H2201/0207 ,  A61H2201/0221 ,  A61H2201/1604 ,  A61H2201/165 ,  A61H2205/022 ,  A61H2205/024 ,  A61N7/00

摘要： Consistent with certain embodiments, an apparatus provides regulated heat to at least one of a patient's eyelids, using a heater unit having a heating element that produces heat that is transferred to the patient's eyelid when an electrical signal is applied thereto. A temperature regulator applies an electrical signal to the heating elements in order to achieve heating of the heating elements to a specified temperature range. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

摘要翻译： 与某些实施例一致，设备使用具有加热元件的加热器单元向患者的眼皮中的至少一个提供调节的热量，所述加热器单元产生当向其施加电信号时传递到患者眼皮的热量。 温度调节器将电信号施加到加热元件，以实现加热元件的加热到指定的温度范围。 该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

公开(公告)号：US20080114421A1

公开(公告)日：2008-05-15

申请号：US12015567

申请日：2008-01-17

申请人： Donald Korb ,  Stephen Grenon

发明人： Donald Korb ,  Stephen Grenon

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61B18/12 ,  A61B2017/00084 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/007 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

摘要： A method of treating meibomian gland dysfunction. Heat is applied to the inside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. Temperatures at the meibomian glands reach desired levels more quickly and efficiently when heating the inside of the eyelid. Reaching such higher temperature levels may be instrumental in removing obstructions in the meibomian glands. Less time may also be required to reach desired temperature levels when applying heat to the inside of the eyelid. A force may also be applied to the inside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions.

摘要翻译： 治疗睑板腺功能障碍的方法。 将热量施加到眼睑内部以提供导热传递到睑板腺。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 在加热眼睑内部时，睑板腺的温度可以更快速有效地达到所需水平。 达到更高的温度水平可能有助于消除睑板腺中的障碍物。 当向眼睑内部施加热量时，也可能需要较少的时间达到所需的温度水平。 也可以将力施加到患者眼睑的内侧，以改善导电传热并减少眼睑中引起对流热损失的血液流动。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。

公开(公告)号：US20070049913A1

公开(公告)日：2007-03-01

申请号：US11541291

申请日：2006-09-29

申请人： Stephen Grenon ,  Lyle Paul ,  Steven Roe ,  Donald Korb

发明人： Stephen Grenon ,  Lyle Paul ,  Steven Roe ,  Donald Korb

IPC分类号： A61B18/04 ,  A61F7/00

CPC分类号： A61F9/0008 ,  A61B18/12 ,  A61B2018/046 ,  A61B2018/048 ,  A61F9/0026 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H35/02 ,  A61H2015/0014 ,  A61H2201/0207 ,  A61H2201/0221 ,  A61H2201/1607 ,  A61H2201/165 ,  A61H2205/022 ,  A61H2205/024 ,  A61N7/00

摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

摘要翻译： 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物从腺体通道孔排出。 本发明包括选择能够传送加热介质射流的装置。 该装置定位成使得当喷射器被施加到眼睑的外表面时，靠近腺体通道孔口，加热介质射流被施加到靠近腺体通道孔口的眼睑的外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分闭塞被去除。 在一个示例性实施例中，介质被水加热到约42℃至约46℃之间的温度。根据障碍物的特定类型和组成，流体射流操作以使阻塞物熔化或软化并且挤奶 将软管堵塞的腺体从睑板腺口对面的端部移出腺体孔。 加热的流体射流的重复施加也可能是软化和/或表达障碍物所必需的。

公开(公告)号：US20080051741A1

公开(公告)日：2008-02-28

申请号：US11931646

申请日：2007-10-31

申请人： Stephen Grenon ,  Lyle Paul ,  Steven Roe ,  Donald Korb

发明人： Stephen Grenon ,  Lyle Paul ,  Steven Roe ,  Donald Korb

IPC分类号： A61F9/00

CPC分类号： A61F9/00 ,  A61B17/3203 ,  A61B18/04 ,  A61B2018/046 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059

摘要： According to the present invention, there is provided a method of treating meibomian gland dysfunction in a mammal wherein an occlusion blocks at least a portion of the flow of naturally occurring secretion out of a gland channel orifice. The invention comprises selecting a device capable of delivering a jet of heated medium. The device is positioned such that when the jet is it is applied to the exterior surface of the eyelid, proximate to the gland channel orifice, a jet of heated medium is applied to the exterior surface of the eyelid proximate to the gland channel orifice at a pressure of from about 2 psi to about 30 psi. Application of the jet of heated medium is maintained for sufficient time to loosen, break up, fracture, soften or liquefy at least a portion of the occlusion such that at least a portion of the occlusion is removed. In an exemplary embodiment, the medium is water heated to a temperature of between about 42° C. and about 46° C. Depending on the particular type and composition of the obstruction, the fluid jet operates to melt or soften the obstruction and to milkingly move the corpus of the softened obstruction up the gland channel from the end opposite the meibomian gland orifice and out of the gland orifice. Repeated application of the heated fluid jet may also be necessary to soften and/or express the obstruction.

摘要翻译： 根据本发明，提供了一种在哺乳动物中治疗睑板腺功能障碍的方法，其中闭塞将至少一部分天然存在的分泌物从腺体通道孔排出。 本发明包括选择能够传送加热介质射流的装置。 该装置定位成使得当喷射器被施加到眼睑的外表面时，靠近腺体通道孔口，加热介质射流被施加到靠近腺体通道孔口的眼睑的外表面 约2psi至约30psi的压力。 维持加热介质喷射器的足够时间以松开，分解，断裂，软化或液化至少一部分闭塞，使得至少一部分闭塞被去除。 在一个示例性实施例中，介质被水加热到约42℃至约46℃之间的温度。根据障碍物的特定类型和组成，流体射流操作以使阻塞物熔化或软化并且挤奶 将软管堵塞的腺体从睑板腺口对面的端部移出腺体孔。 加热的流体射流的重复施加也可能是软化和/或表达障碍物所必需的。

公开(公告)号：US20080114425A1

公开(公告)日：2008-05-15

申请号：US12015675

申请日：2008-01-17

申请人： Donald Korb ,  Stephen Grenon

发明人： Donald Korb ,  Stephen Grenon

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61B18/12 ,  A61B2017/00084 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/007 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the inside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. Temperatures at the meibomian glands reach desired levels more quickly and efficiently when heating the inside of the eyelid. Reaching such higher temperature levels may be instrumental in removing obstructions in the meibomian glands. Less time may also be required to reach desired temperature levels when applying heat to the inside of the eyelid. A force may also be applied to the inside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions.

摘要翻译： 治疗睑板腺功能障碍的系统。 控制器控制施加到眼睑内部的热量，以向睑板腺提供导电热传递。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 在加热眼睑内部时，睑板腺的温度可以更快速有效地达到所需水平。 达到更高的温度水平可能有助于消除睑板腺中的障碍物。 当向眼睑内部施加热量时，也可能需要较少的时间达到所需的温度水平。 也可以将力施加到患者眼睑的内侧，以改善导电传热并减少眼睑中引起对流热损失的血液流动。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。

公开(公告)号：US20080114424A1

公开(公告)日：2008-05-15

申请号：US12015600

申请日：2008-01-17

申请人： Stephen Grenon ,  John Jans ,  Jordan Hutchinson ,  Keith Gausmann

发明人： Stephen Grenon ,  John Jans ,  Jordan Hutchinson ,  Keith Gausmann

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61B18/12 ,  A61B2017/00084 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/007 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

摘要： A system for treating meibomian gland dysfunction. A controller controls a lid warmer attached onto a patient's eye to generate heat on the inside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. Temperatures at the meibomian glands reach desired levels more quickly and efficiently when heating the inside of the eyelid. Reaching such higher temperature levels may be instrumental in removing obstructions in the meibomian glands. Less time may also be required to reach desired temperature levels when applying heat to the inside of the eyelid. An eyecup may be employed to generate a force on the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions.

摘要翻译： 治疗睑板腺功能障碍的系统。 控制器控制附着在患者眼睛上的盖子加热器，以在眼睑内部产生热量，以向睑板腺提供导电热传递。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 在加热眼睑内部时，睑板腺的温度可以更快速有效地达到所需水平。 达到更高的温度水平可能有助于消除睑板腺中的障碍物。 当向眼睑内部施加热量时，也可能需要较少的时间达到所需的温度水平。 可以使用眼罩在患者眼皮的外侧产生力，以改善导电热传递并减少引起对流热损失的眼睑中的血流。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。

公开(公告)号：US20080114423A1

公开(公告)日：2008-05-15

申请号：US12015593

申请日：2008-01-17

申请人： Stephen Grenon ,  John Jans ,  Jordan Hutchinson ,  Keith Gausmann

发明人： Stephen Grenon ,  John Jans ,  Jordan Hutchinson ,  Keith Gausmann

IPC分类号： A61F7/12

CPC分类号： A61F9/00772 ,  A61B17/22 ,  A61B18/08 ,  A61B18/12 ,  A61B2017/00084 ,  A61B2017/22082 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/007 ,  A61F7/02 ,  A61F7/12 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61F2007/0071 ,  A61F2007/0086 ,  A61F2007/0091 ,  A61F2007/0096 ,  A61F2007/0249 ,  A61F2007/0282 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

摘要： An apparatus for treating meibomian gland dysfunction. A lid warmer may be attached onto a patient's eye to apply heat on the inside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. Temperatures at the meibomian glands reach desired levels more quickly and efficiently when heating the inside of the eyelid. Reaching such higher temperature levels may be instrumental in removing obstructions in the meibomian glands. Less time may also be required to reach desired temperature levels when applying heat to the inside of the eyelid. An eyecup may also be employed to generate a force on the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions.

摘要翻译： 一种治疗睑板腺功能障碍的装置。 盖子加热器可以附着在患者的眼睛上以在眼睑内部施加热量，以向睑板腺提供导电热传递。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 在加热眼睑内部时，睑板腺的温度可以更快速有效地达到所需水平。 达到更高的温度水平可能有助于消除睑板腺中的障碍物。 当向眼睑内部施加热量时，也可能需要较少的时间达到所需的温度水平。 还可以使用眼罩在患者眼皮的外侧产生力以改善导电传热并减少引起对流热损失的眼睑中的血流。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。