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    Treatment of meibomian glands
    3.
    发明申请
    Treatment of meibomian glands 有权
    治疗睑板腺

    公开(公告)号：US20070027431A1

    公开(公告)日：2007-02-01

    申请号：US11541418

    申请日：2006-09-29

    申请人： Donald Korb ,  Timothy Willis ,  Stephen Grenon

    发明人： Donald Korb ,  Timothy Willis ,  Stephen Grenon

    IPC分类号： A61M35/00

    CPC分类号： A61B17/22004 ,  A61B18/12 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/02 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

    摘要： In one embodiment consistent with the present invention a method of treating mammalian meibomian glands involves clearing the glands by applying a regulated heat to an eyelid containing the meibomian glands to a temperature adequate to melt obstructions in the meibomian glands to put the obstructions in a fluid or suspension (melted) state and maintaining the heat for a time period adequate to melt the obstructions. The glands can then be mechanically treated to express fluid from the glands, wherein the treating is carried out either during the time period or after the time period but while the obstruction remains in a fluid state. Subsequent pharmacological treatment of the glands by use a pharmacological agent (topical or systemic) can then be used to assist in maintaining proper flow of lipids from the glands. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

    摘要翻译： 在与本发明一致的一个实施方案中，治疗哺乳动物睑板腺的方法涉及通过将含有睑板腺的眼睑施加调节的热量至足以融化睑板腺中的阻塞物以将阻塞物置于流体中的方式来清除腺体，或 悬浮（熔化）状态并将热量保持足够的时间以融化障碍物。 然后可以对腺体进行机械处理以从腺体表达流体，其中治疗在时间段期间或在时间段之后进行，但是当阻塞物保持在流体状态时。 然后通过使用药物（局部或全身）对腺体进行的后续药理学治疗可用于帮助保持来自腺体的适当的脂质流动。 该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

    SYSTEM FOR OUTER EYELID HEAT AND PRESSURE TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION
    4.
    发明申请
    SYSTEM FOR OUTER EYELID HEAT AND PRESSURE TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
    用于治疗脑血管性功能障碍的外眼热疗和压力治疗系统

    公开(公告)号：US20080114426A1

    公开(公告)日：2008-05-15

    申请号：US12015683

    申请日：2008-01-17

    申请人： Donald Korb ,  Stephen Grenon ,  Timothy Willis ,  Benjamin Gravely

    发明人： Donald Korb ,  Stephen Grenon ,  Timothy Willis ,  Benjamin Gravely

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61B18/12 ,  A61B2017/00084 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/007 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

    摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force is also applied to the outside of the patient's eyelid during the application of heat to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.

    摘要翻译： 治疗睑板腺功能障碍的系统。 控制器控制施加到眼睑外部的热量，以向睑板腺提供传导热传递。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 在施加热量的同时也将力施加到患者眼皮的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。 达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

    SYSTEM FOR PROVIDING HEAT TREATMENT AND HEAT LOSS REDUCTION FOR TREATING MEIBOMIAN GLAND DYSFUNCTION
    5.
    发明申请
    SYSTEM FOR PROVIDING HEAT TREATMENT AND HEAT LOSS REDUCTION FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
    用于治疗脑血管功能障碍的热处理和热量减少系统

    公开(公告)号：US20080114427A1

    公开(公告)日：2008-05-15

    申请号：US12015721

    申请日：2008-01-17

    申请人： Donald Korb ,  Stephen Grenon ,  Timothy Willis ,  John Jans

    发明人： Donald Korb ,  Stephen Grenon ,  Timothy Willis ,  John Jans

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61B18/12 ,  A61B2017/00084 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/007 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

    摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the tissue proximate the patient's meibomian glands to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force is also applied to tissue proximate the patient's meibomian glands during the application of heat to improve conductive heat transfer and reduce blood flow in tissue that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands. Reducing the amount of time to reached desired temperature levels an aid in reducing discomfort to the patient during treatment.

    摘要翻译： 治疗睑板腺功能障碍的系统。 控制器控制施加到患者睑板腺附近的组织的热量，以向睑板腺提供导电热传递。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 在施加热量的同时，还将力施加到患者睑板腺附近的组织以改善导电传热并减少导致对流热损失的组织中的血流。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。 达到升高的温度水平可能会改善睑板腺的阻塞或闭塞的融化，松动或软化。 减少达到所需温度水平的时间量，有助于减轻治疗期间患者的不适。

    HEAT TREATMENT AND HEAT LOSS REDUCTION FOR TREATING MEIBOMIAN GLAND DYSFUNCTION
    6.
    发明申请
    HEAT TREATMENT AND HEAT LOSS REDUCTION FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
    治疗脑血管功能障碍的热处理和热损失

    公开(公告)号：US20080114422A1

    公开(公告)日：2008-05-15

    申请号：US12015584

    申请日：2008-01-17

    申请人： Donald Korb ,  Stephen Grenon ,  Timothy Willis ,  John Jans

    发明人： Donald Korb ,  Stephen Grenon ,  Timothy Willis ,  John Jans

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61B18/12 ,  A61B2017/00084 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/007 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

    摘要： A method of treating meibomian gland dysfunction. Heat is applied to the tissue proximate the patient's meibomian glands to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the tissue proximate the patient's meibomian glands to improve conductive heat transfer and reduce blood flow in the tissue that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reached desired temperature levels and/or aid in reducing discomfort to the patient during treatment.

    摘要翻译： 治疗睑板腺功能障碍的方法。 将热量施加到患者睑板腺附近的组织，以向睑板腺提供导电热传递。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 也可以将力施加到患者睑板腺附近的组织，以改善传导性热传递并减少组织中造成对流热损失的血液流动。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。 达到升高的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到所需温度水平的时间量和/或有助于减轻治疗期间患者的不适。

    TREATMENT OF OBSTRUCTIVE DISORDERS OF THE EYE OR EYELID
    7.
    发明申请
    TREATMENT OF OBSTRUCTIVE DISORDERS OF THE EYE OR EYELID 有权
    治疗眼睛或眼睛的阻塞性疾病

    公开(公告)号：US20080046048A1

    公开(公告)日：2008-02-21

    申请号：US11928681

    申请日：2007-10-30

    申请人： Stephen Grenon ,  Donald Korb ,  Timothy Willis

    发明人： Stephen Grenon ,  Donald Korb ,  Timothy Willis

    IPC分类号： A61F7/00

    CPC分类号： A61B17/22004 ,  A61B17/22 ,  A61F7/02 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0261

    摘要： In accordance with certain illustrative embodiments, methods and apparatuses of treating obstructive disorders of the structure of an eye or eyelid are disclosed. The treating may involve applying heat to the structure containing the obstructive disorder to melt an obstruction in the structure and place the obstruction in a melted state. The heat may be maintained for a time period to melt the obstruction and place the obstruction in the melted state. The structure may be treated by expressing the melted obstruction from the structure. The treating may be carried out either during the time period or after the time period when heat is applied but while the obstruction is in the melted state. In certain embodiments, the method further involves subsequently treating the structure by use of a pharmacological agent. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

    摘要翻译： 根据某些示例性实施例，公开了治疗眼睛或眼睑结构的阻塞性疾病的方法和装置。 治疗可以涉及对包含阻塞性病症的结构施加热量，以便熔化结构中的梗阻并将阻塞置于熔化状态。 可以将热量保持一段时间以融化阻塞物并将阻塞物置于熔化状态。 可以通过从结构中表达熔化的阻塞来处理结构。 处理可以在施加热量但是阻塞处于熔化状态的时间段期间之后或者在施加热量的时间段之后进行。 在某些实施方案中，该方法还涉及随后通过使用药理学剂处理该结构。 该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

    INNER EYELID TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION
    10.
    发明申请
    INNER EYELID TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
    用于治疗脑血管性功能障碍的内眼治疗

    公开(公告)号：US20080114420A1

    公开(公告)日：2008-05-15

    申请号：US12015558

    申请日：2008-01-17

    申请人： Donald Korb ,  Stephen Grenon ,  Timothy Willis ,  Benjamin Gravely

    发明人： Donald Korb ,  Stephen Grenon ,  Timothy Willis ,  Benjamin Gravely

    IPC分类号： A61F7/12

    CPC分类号： A61F7/12 ,  A61B18/12 ,  A61B2017/00084 ,  A61B2018/046 ,  A61B2018/048 ,  A61F7/007 ,  A61F9/00772 ,  A61F2007/0004 ,  A61F2007/0059 ,  A61H7/00 ,  A61H2015/0014 ,  A61N7/00

    摘要： A method of treating meibomian gland dysfunction. Heat is applied to the inside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. Temperatures at the meibomian glands reach desired levels more quickly and efficiently when heating the inside of the eyelid. Reaching such higher temperature levels may be instrumental in removing obstructions in the meibomian glands. Less time may also be required to reach desired temperature levels when applying heat to the inside of the eyelid. A force may also be applied to the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions.

    摘要翻译： 治疗睑板腺功能障碍的方法。 将热量施加到眼睑内部以提供导热传递到睑板腺。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 在加热眼睑内部时，睑板腺的温度可以更快速有效地达到所需水平。 达到更高的温度水平可能有助于消除睑板腺中的障碍物。 当向眼睑内部施加热量时，也可能需要较少的时间达到所需的温度水平。 也可以将力施加到患者眼睑的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。