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15 条记录 (耗时 0.026 秒)

    Quick dissolve compositions and tablets based thereon
    11.
    发明授权
    Quick dissolve compositions and tablets based thereon 有权
    快速溶解组合物和片剂

    公开(公告)号：US07815937B2

    公开(公告)日：2010-10-19

    申请号：US10176135

    申请日：2002-06-21

    申请人： Naima Mezaache ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman ,  Djelila Mezaache

    发明人： Naima Mezaache ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman ,  Djelila Mezaache

    IPC分类号： A61K9/20

    CPC分类号： A61K9/1617 ,  A61K9/0056 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/2077 ,  A61K9/2081 ,  A61K9/2095 ,  A61K9/5026 ,  A61K9/5042 ,  A61K31/366 ,  A61K31/426 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38

    摘要： The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

    摘要翻译： 本发明提供了一种组合物，其可用于制备能够在少于40秒内溶解于口中的口服剂型，而不需要常规的超级崩解剂并具有小于1％的脆性; 其中所述组合物包括液体微粒和赋形剂。 根据本发明优选的赋形剂组合物包含直接可压缩的无机盐; 纤维素衍生物或直接可压缩的无机盐和纤维素衍生物的组合。 优选地，液体颗粒和赋形剂组合的比例使得当组合物被压缩以获得硬度为20至50N的剂型时，活性成分基本保持在微球内。本发明的组合物允许 制造具有改善的硬度和脆性的口服剂量。

    System for rendering substantially non-dissoluble bio-affecting agents bio-available
    12.
    发明授权
    System for rendering substantially non-dissoluble bio-affecting agents bio-available 有权
    用于使生物可用的基本上不可溶的生物影响剂呈现的系统

    公开(公告)号：US06391338B1

    公开(公告)日：2002-05-21

    申请号：US09138194

    申请日：1998-08-21

    申请人： Steven E. Frisbee ,  Garry L. Myers ,  Richard C. Fuisz ,  Andrea S. Blake ,  Robert K. Yang

    发明人： Steven E. Frisbee ,  Garry L. Myers ,  Richard C. Fuisz ,  Andrea S. Blake ,  Robert K. Yang

    IPC分类号： A61K926

    CPC分类号： B01J13/04 ,  A01N25/10 ,  A61K9/146 ,  A61K9/70 ,  Y10S514/965

    摘要： The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a molecular dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available (“bio-available”) to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.

    摘要翻译： 本发明是制备用于递送生物影响剂的系统的方法和由其制备的组合物。 本发明包括在与生物影响剂相容的水溶性聚合物中以增加的能量状态形成生物影响剂的分子分散体。 作为将生物影响剂转化为增加能量条件并在这种条件下在水溶性聚合物中冷冻的结果，生物影响剂在生物系统上可用（“生物可用”） 聚合物的溶解。 已经发现，该方法和组合物对于递送基本上不可溶的药物和其它生物影响成分非常有效。