System for rendering substantially non-dissoluble bio-affecting agents bio-available
    3.
    发明授权
    System for rendering substantially non-dissoluble bio-affecting agents bio-available 有权
    用于使生物可用的基本上不可溶的生物影响剂呈现的系统

    公开(公告)号:US06391338B1

    公开(公告)日:2002-05-21

    申请号:US09138194

    申请日:1998-08-21

    IPC分类号: A61K926

    摘要: The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a molecular dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available (“bio-available”) to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.

    摘要翻译: 本发明是制备用于递送生物影响剂的系统的方法和由其制备的组合物。 本发明包括在与生物影响剂相容的水溶性聚合物中以增加的能量状态形成生物影响剂的分子分散体。 作为将生物影响剂转化为增加能量条件并在这种条件下在水溶性聚合物中冷冻的结果,生物影响剂在生物系统上可用(“生物可用”) 聚合物的溶解。 已经发现,该方法和组合物对于递送基本上不可溶的药物和其它生物影响成分非常有效。

    Entrapping additives in carbohydrate bodies
    4.
    发明授权
    Entrapping additives in carbohydrate bodies 失效
    在碳水化合物体中包埋添加剂

    公开(公告)号:US5874110A

    公开(公告)日:1999-02-23

    申请号:US898306

    申请日:1997-07-22

    IPC分类号: A61K9/16 A61K9/14

    摘要: The present invention is a method of entrapping an additive within carbohydrate bodies. The additive is drawn into the internal structure as a fluid during transformation of the bodies from a substantially amorphous state to a crystalline state. The present invention is also a delivery system including a carbohydrate body having an internal free volume space defined by an at least partially crystalline structure at equilibrium conditions, and an additive loaded within the carbohydrate body.

    摘要翻译: 本发明是在碳水化合物体内捕获添加剂的方法。 在将体从基本无定形状态转变为结晶状态时,添加剂作为流体被吸入内部结构。 本发明还是一种递送系统,其包括在平衡条件下具有由至少部分结晶结构限定的内部自由体积空间的碳水化合物体和在碳水化合物体内加载的添加剂。