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1.发明授权System for rendering substantially non-dissoluble bio-affecting agents bio-available 有权用于使生物可用的基本上不可溶的生物影响剂呈现的系统公开(公告)号：US06391338B1
公开(公告)日：2002-05-21
申请号：US09138194
申请日：1998-08-21
IPC分类号： A61K926
CPC分类号： B01J13/04 , A01N25/10 , A61K9/146 , A61K9/70 , Y10S514/965
摘要： The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a molecular dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available (“bio-available”) to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.
摘要翻译： 本发明是制备用于递送生物影响剂的系统的方法和由其制备的组合物。 本发明包括在与生物影响剂相容的水溶性聚合物中以增加的能量状态形成生物影响剂的分子分散体。 作为将生物影响剂转化为增加能量条件并在这种条件下在水溶性聚合物中冷冻的结果，生物影响剂在生物系统上可用（“生物可用”） 聚合物的溶解。 已经发现，该方法和组合物对于递送基本上不可溶的药物和其它生物影响成分非常有效。
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2.发明申请THIN FILM WITH NON-SELF-AGGREGATING UNIFORM HETEROGENEITY AND DRUG DELIVERY SYSTEMS MADE THEREFROM 有权具有非自我聚集均匀异质性和药物输送系统的薄膜公开(公告)号：US20090181069A1
公开(公告)日：2009-07-16
申请号：US12411505
申请日：2009-03-26
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7015 , A61K31/192 , A61K31/422 , A61K31/435 , A61K31/4525 , A61K31/4545 , A61K31/80 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/38 , A61K47/44 , A61K47/46 , C08J5/18
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
摘要翻译： 本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。 理想地，膜在水中分解，并且可以通过受控的干燥过程或保持膜所需均匀性的其它方法形成。
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3.发明申请公开(公告)号：US20080268027A1
公开(公告)日：2008-10-30
申请号：US12171692
申请日：2008-07-11
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7015 , A61K31/192 , A61K31/422 , A61K31/435 , A61K31/4525 , A61K31/4545 , A61K31/80 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/38 , A61K47/44 , A61K47/46 , C08J5/18
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
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4.发明授权
公开(公告)号：US6083430A
公开(公告)日：2000-07-04
申请号：US642026
申请日：1996-04-29
申请人： Richard C. Fuisz , Garry L. Myers , Robert K. Yang , Mark R. Herman , Whitney S. Cavanagh , John R. Sisak , Andrea S. Brothers
发明人： Richard C. Fuisz , Garry L. Myers , Robert K. Yang , Mark R. Herman , Whitney S. Cavanagh , John R. Sisak , Andrea S. Brothers
IPC分类号： A61J3/02 , A61J1/00 , A61J7/00 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/50 , B01J2/00 , B01J2/02 , A61K9/14
CPC分类号： A61J1/00 , A61J7/0015 , A61K9/1688 , A61K9/1694 , A61K9/2081 , A61K9/2095 , A61K9/5026 , B01J2/00 , B01J2/02
摘要： The present invention is a process and apparatus for making a dosage unit by direct tableting of shearlite particles. The present invention also includes the dosage unit itself. Shearlite particles, which are prepared by subjecting a feedstock material to liquiflash processing, can be directly fed from a shearlite device to a tableting apparatus without the necessity of any intermediate steps or additional ingredients to facilitate flowability or tablet formation.
摘要翻译： 本发明是通过直接压片剪切碎片制造剂量单位的方法和装置。 本发明还包括剂量单位本身。 通过使原料进行液化处理制备的剪切剂颗粒可以从剪切装置直接进给到压片装置，而不需要任何中间步骤或附加成分来促进流动性或形成片剂。
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5.发明授权Uniform films for rapid dissolve dosage form incorporating taste-masking compositions 有权包含掩味组合物的快速溶解剂型的均匀膜公开(公告)号：US08603514B2
公开(公告)日：2013-12-10
申请号：US11775484
申请日：2007-07-10
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/14 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5036 , A61K9/5047 , A61K9/7015 , A61K31/138 , A61K31/192 , A61K31/422 , A61K31/44 , A61K31/4422 , A61K31/443 , A61K31/4545 , A61K31/519 , A61K31/549 , A61K31/567 , A61K31/635 , A61K31/704 , A61K31/7048 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61K47/46 , B05D3/0254 , B29C47/0004
摘要： The present invention relates to rapid dissolve thin film drug delivery compositions for the oral administration of active components. The active components are provided as taste-masked or controlled-release coated particles uniformly distributed throughout the film composition. The compositions may be formed by wet casting methods, where the film is cast and controllably dried, or alternatively by an extrusion method.
摘要翻译： 本发明涉及用于口服给药活性成分的快速溶解薄膜药物递送组合物。 活性组分作为均匀分布在整个膜组合物中的掩味或控释包衣颗粒提供。 组合物可以通过湿法铸造方法形成，其中膜被浇铸并可控制地干燥，或者通过挤出方法形成。
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6.发明申请公开(公告)号：US20110278763A1
公开(公告)日：2011-11-17
申请号：US13035328
申请日：2011-02-25
IPC分类号： B29C39/02
CPC分类号： A61K8/731 , A61K8/0216 , A61K8/86 , A61K9/006 , A61K9/7007 , A61K9/7015 , A61K2800/92 , A61Q11/00 , C08J5/18 , C08J2371/02 , F26B13/104
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
摘要翻译： 本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。 期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。 膜包含聚合物组分，其包括任选地与亲水性纤维素聚合物共混的聚环氧乙烷。 理想地，该膜还含有每单位面积膜的活性剂药物和/或化妆品活性剂不超过10％的药物和/或化妆品活性剂。
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公开(公告)号：US5965164A
公开(公告)日：1999-10-12
申请号：US642027
申请日：1996-04-29
IPC分类号： A61J3/02 , A61J1/00 , A61J7/00 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/50 , B01J2/00 , B01J2/02 , A61K9/14
CPC分类号： A61J7/0023 , A61J1/00 , A61J7/0015 , A61J7/0046 , A61K9/1688 , A61K9/1694 , A61K9/2081 , A61K9/2095 , A61K9/5026 , B01J2/00 , B01J2/02
摘要： A recipient-dosage delivery system including shearlite particles of a bio-affecting agent for delivery to a recipient. The particles are provided in a metered dose and are packaged in a bi-functional vessel. The particles are produced under liquiflash conditions and exhibit sufficient flowability so as to allow administration of the metered dose to the recipient under the force of gravity.
摘要翻译： 受体剂量递送系统，其包括用于递送至接受者的生物影响剂的剪切碎片颗粒。 颗粒以计量剂量提供并且包装在双功能容器中。 颗粒在液化条件下产生并显示出足够的流动性，以便允许在重力作用下将计量剂量给予受体。
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8.发明授权Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom 有权具有非自聚集均匀异质性的薄膜和由其制成的药物递送系统公开(公告)号：US08685437B2
公开(公告)日：2014-04-01
申请号：US12411505
申请日：2009-03-26
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7015 , A61K31/192 , A61K31/422 , A61K31/435 , A61K31/4525 , A61K31/4545 , A61K31/80 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/38 , A61K47/44 , A61K47/46 , C08J5/18
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
摘要翻译： 本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。 理想地，膜在水中分解，并且可以通过受控的干燥过程或保持膜所需均匀性的其它方法形成。
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9.发明申请THIN FILM WITH NON-SELF-AGGREGATING UNIFORM HETEROGENEITY AND DRUG DELIVERY SYSTEMS MADE THEREFROM 审中-公开具有非自我聚集均匀异质性和药物输送系统的薄膜公开(公告)号：US20120128848A1
公开(公告)日：2012-05-24
申请号：US13342614
申请日：2012-02-02
CPC分类号： A61J3/00 , A61K9/006 , A61K9/7007 , B29C48/08 , B29C48/91 , B29C48/919 , F26B13/10 , F26B13/104
摘要： The invention relates to film products containing desired levels of active components and methods of their preparation. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films may be exposed to temperatures above that at which the active components typically degrade without concern for loss of the desired activity.
摘要翻译： 本发明涉及含有所需水平的活性成分的薄膜产品及其制备方法。 期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。 期望地，膜可以暴露于高于活性组分通常降解的温度，而不考虑所需活性的损失。
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公开(公告)号：US08017150B2
公开(公告)日：2011-09-13
申请号：US12107389
申请日：2008-04-22
IPC分类号： A61K9/14
CPC分类号： A61K8/731 , A61K8/0216 , A61K8/86 , A61K9/006 , A61K9/7007 , A61K9/7015 , A61K2800/92 , A61Q11/00 , C08J5/18 , C08J2371/02 , F26B13/104
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
摘要翻译： 本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。 期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。 膜包含聚合物组分，其包括任选地与亲水性纤维素聚合物共混的聚环氧乙烷。 期望地，膜还含有药物和/或化妆品活性剂，其每单位面积膜的活性剂药物和/或美容活性剂的变化不超过10％。
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