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公开(公告)号：US20120316570A1
公开(公告)日：2012-12-13
申请号：US13591147
申请日：2012-08-21
IPC分类号： B05D5/00 , C01G23/047 , C01F11/02 , A61B17/88
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue. In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof. A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
摘要翻译： 本发明基于在骨组织中的局部施用锶离子已经被发现在植入骨组织植入物在所述骨组织中时改善骨形成和骨量。 具体地说，本发明涉及具有由包含锶离子的氧化物层覆盖的植入物表面的骨组织植入物及其制造方法。 本发明还提供了包含锶离子的喷砂粉末，局部增加骨形成的方法，以及使用锶离子或其盐来制造用于局部增加骨形成的药物组合物。
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公开(公告)号：US20100174382A1
公开(公告)日：2010-07-08
申请号：US12299010
申请日：2008-07-08
CPC分类号： A61L27/306 , A61C8/0009 , A61F2/30767 , A61F2002/30677 , A61F2310/00598 , A61L27/06 , A61L27/50
摘要： The present invention is based on that local administration of strontium ions in bone tissue has been found to improve the bone formation and bone mass upon implantation of a bone tissue implant in said bone tissue.In particular, the invention relates to a bone tissue implant having an implant surface covered by an oxide layer comprising strontium ions and a method for the manufacture thereof.A blasting powder comprising strontium ions, a method for locally increasing bone formation, and the use of strontium ions or a salt thereof for manufacturing a pharmaceutical composition for locally increasing bone formation are also provided by the present invention.
摘要翻译： 本发明基于在骨组织中的局部施用锶离子已经被发现在植入骨组织植入物在所述骨组织中时改善骨形成和骨量。 具体地说，本发明涉及具有由包含锶离子的氧化物层覆盖的植入物表面的骨组织植入物及其制造方法。 本发明还提供了包含锶离子的喷砂粉末，局部增加骨形成的方法，以及使用锶离子或其盐来制造用于局部增加骨形成的药物组合物。
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公开(公告)号：US20100173264A1
公开(公告)日：2010-07-08
申请号：US12298884
申请日：2008-07-08
CPC分类号： A61F2/30767 , A61C8/0012 , A61C2008/0046 , A61F2/3094 , A61F2002/30719 , A61F2002/30906 , A61F2002/30925 , A61F2002/30929 , A61F2250/0092 , A61F2310/00023 , A61F2310/00598 , A61F2310/00616 , A61L27/306 , A61L2400/12 , B82Y5/00 , B82Y30/00 , C23C8/00 , C23C8/10 , C23C22/46 , C23C26/00 , C23G1/106
摘要： The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid; whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.
摘要翻译： 本发明涉及生物相容性成分的修饰方法，包括以下步骤：a）提供至少部分被金属氧化物覆盖的生物相容性成分; 和b）用包含草酸的含水组合物处理所述部分被所述金属氧化物覆盖的部分的至少一部分; 得到改性金属氧化物。 本发明还涉及一种生物相容性成分，其包含具有表面的基底，该基底包括a）微结构，其包括由平片和/或脊分离的凹坑; 和b）叠加在所述微结构上的初级纳米结构，所述初级纳米结构包括布置成波状结构的凹陷。
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