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32 条记录 (耗时 0.024 秒)

    Methods and Compositions for Modulating Angiogenesis
    11.
    发明申请
    Methods and Compositions for Modulating Angiogenesis 审中-公开
    调节血管生成的方法和组合

    公开(公告)号：US20110172293A1

    公开(公告)日：2011-07-14

    申请号：US13001604

    申请日：2009-07-01

    申请人： Jason E. Fish ,  Deepak Srivastava

    发明人： Jason E. Fish ,  Deepak Srivastava

    IPC分类号： A61K31/7088 ,  C07H21/04 ,  C12N15/63 ,  A61P35/00

    CPC分类号： C12N15/113 ,  A61K31/70 ,  A61K31/7088 ,  A61K45/06 ,  C12N2310/11 ,  C12N2310/141 ,  C12N2320/30

    摘要： The present invention provides compositions comprising antisense nucleic acids that reduce miR-126 levels in an endothelial cell. The present invention provides compositions comprising a target protector nucleic acid. The present invention provides methods of modulating angiogenesis in an individual, the methods generally involving administering to the individual an effective amount of an agent that increases or that decreases the level of miR-126 in endothelial cells of the individual.

    摘要翻译： 本发明提供包含减少内皮细胞中的miR-126水平的反义核酸的组合物。 本发明提供了包含靶标保护核酸的组合物。 本发明提供了调节个体血管发生的方法，所述方法通常涉及向个体施用有效量的增加或降低个体内皮细胞中miR-126水平的药剂。

    METHODS FOR INDUCING CARDIOMYOGENESIS
    13.
    发明申请
    METHODS FOR INDUCING CARDIOMYOGENESIS 审中-公开
    诱导心肌细胞发生的方法

    公开(公告)号：US20100129915A1

    公开(公告)日：2010-05-27

    申请号：US12513657

    申请日：2007-11-09

    申请人： Deepak Srivastava ,  Chulan Kwon

    发明人： Deepak Srivastava ,  Chulan Kwon

    IPC分类号： C12N15/86 ,  C12N5/02

    CPC分类号： C12N5/0657 ,  C12N2501/415

    摘要： The present invention provides methods of inducing cardiomyogenesis and expansion of cardiac progenitors in a population of stem cells or progenitor cells, the methods generally involving inducing a canonical Wnt signaling pathway in the stem cells or progenitor cells. The present invention provides methods of generating a population of cardiomyocytes or cardiac progenitors from a population of stem cells or progenitor cells, the methods generally involving contacting the stem cells or progenitor cells with an agent that induces canonical Wnt signaling. A subject method is useful for generating a population of cardiomyocytes or cardiac progenitors, which can be used in research and therapeutic applications.

    摘要翻译： 本发明提供了在干细胞或祖细胞群中诱导心脏发生和扩增心脏祖细胞的方法，所述方法通常涉及在干细胞或祖细胞中诱导典型的Wnt信号通路。 本发明提供从干细胞或祖细胞群体产生心肌细胞群或心脏祖细胞的方法，所述方法通常包括使干细胞或祖细胞与诱导规范Wnt信号传导的药物接触。 主题方法可用于产生心肌细胞或心脏祖细胞群体，其可用于研究和治疗应用。

    Li-ion battery capacity and voltage prediction using quantum simulations
    14.
    发明授权
    Li-ion battery capacity and voltage prediction using quantum simulations 有权

    公开(公告)号：US10177398B2

    公开(公告)日：2019-01-08

    申请号：US12953068

    申请日：2010-11-23

    申请人： Jun Li ,  Deepak Srivastava ,  Sang Yang

    发明人： Jun Li ,  Deepak Srivastava ,  Sang Yang

    IPC分类号： H01M10/00 ,  H01M10/052 ,  H01M10/0525 ,  G06F17/50 ,  G06F19/00

    摘要： Provided are methods and computer programs for predicting lithium battery properties. One method includes operations for selecting candidate structures for the battery, and for obtaining a plurality of delithiated structures of the candidate structures with different lithium concentrations. The quantum mechanical (QM) energies of the delithiated structures are calculated, and a functional form is developed to obtain the voltage of the lithium battery. The functional form is a function of the lithium concentration and is based on the QM energies of the delithiated structures. Further, the capacity of the lithium battery is calculated based on a selected lithium concentration, where the functional form returns a cut-off voltage of the lithium battery when the lithium concentration is equal to the selected lithium concentration.

    Simulated X-ray diffraction spectra for analysis of crystalline materials
    15.
    发明授权
    Simulated X-ray diffraction spectra for analysis of crystalline materials 有权
    用于分析晶体材料的模拟X射线衍射光谱

    公开(公告)号：US09589098B2

    公开(公告)日：2017-03-07

    申请号：US12953080

    申请日：2010-11-23

    申请人： Deepak Srivastava ,  Sang Yang ,  Jun Li

    发明人： Deepak Srivastava ,  Sang Yang ,  Jun Li

    IPC分类号： G06G7/48 ,  G06F19/00

    CPC分类号： G06F19/00 ,  H01M10/00 ,  H01M10/0525

    摘要： Methods and computer programs to quantify defects in an experimentally synthesized material for use in a battery are provided. A method includes an operation for obtaining spectra of the experimentally synthesized material. Further, defected structures of a crystalline structure are created via simulation, and spectra of the defected structures are obtained via simulation. In another method operation, the spectra of the experimentally synthesized material is compared to the spectra of the defected structures obtained via simulation, and if the spectra of the experimentally synthesized material is substantially equal to the spectra of the defected structures obtained via simulation then the defects in the experimentally synthesized material are quantified according to the defects in the defected structures.

    摘要翻译： 提供了用于量化用于电池的实验合成材料中的缺陷的方法和计算机程序。 一种方法包括获得实验合成材料的光谱的操作。 此外，通过模拟产生晶体结构的缺陷结构，并且通过模拟获得缺陷结构的光谱。 在另一种方法操作中，将实验合成材料的光谱与通过模拟获得的缺陷结构的光谱进行比较，并且如果实验合成材料的光谱基本上等于通过模拟获得的缺陷结构的光谱，则缺陷 在实验合成材料中根据缺陷结构的缺陷量化。