公开(公告)号：US06423741B1

公开(公告)日：2002-07-23

申请号：US09538439

申请日：2000-03-29

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Ajit Kumar Shasany ,  Dharam Chand Jain ,  Mahendra Pandurang Darokar ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Ajit Kumar Shasany ,  Dharam Chand Jain ,  Mahendra Pandurang Darokar ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： A61K31335

CPC分类号： A61K31/352

摘要： This invention is related to the development of strategic and novel composition comprising &agr; arteether and nalidixic acid or quinolone drugs, said composition useful as an advanced generation drug to counter the resistance development itself and having a potential to be used in treating infectious diseases and in inhibiting the resistance developed due to mutation in the gyr A gene of bacteria, particularly in those cases where drug resistant strains are known to appear very frequently.

摘要翻译： 本发明涉及包含α-萜烯和萘啶酸或喹诺酮类药物的战略和新型组合物的发展，所述组合物可用作抗逆转发展本身并具有用于治疗感染性疾病和抑制作用的潜力 由于细菌的gyr A基因突变而产生的抗性，特别是在已知耐药菌株出现频繁的情况下。

公开(公告)号：US06420174B1

公开(公告)日：2002-07-16

申请号：US09536379

申请日：2000-03-28

申请人： Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Sunita Dhawan ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Sunita Dhawan ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： C12N500

CPC分类号： A01H4/005 ,  A01H4/008 ,  C12N5/04

摘要： The present invention is related to a method of producing organogenetic tissues from a plant of the genus Mentha, said method comprising the steps of culturing an explant from a plant of genus Mentha on an initiation medium in the presence of 400 to 600 lux light at a temperature of 23-27° C., with 16 hours of photoperiod, to obtain calli, transferring the calli to a basal medium comprising minerals and vitamins to ensure development of shoots, and culturing the shoots in a medium substantially free of growth hormones and containing menthol in a concentration of about 80 &mgr;g ml−1 to ensure root formation.

摘要翻译： 本发明涉及一种从薄荷属植物生产有机发育组织的方法，所述方法包括以下步骤：在400至600勒克斯光的存在下，在起始培养基上培养来自芒特属植物的外植体， 温度为23-27℃，光周期为16小时，以获得愈伤组织，将愈伤组织转移到包含矿物质和维生素的基础培养基中，以确保芽的发育，并在基本上不含生长激素的培养基中培养芽，并含有 浓缩约80毫升ml-1的薄荷醇以确保根形成。

公开(公告)号：US07235262B2

公开(公告)日：2007-06-26

申请号：US10822790

申请日：2004-04-13

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06979471B1

公开(公告)日：2005-12-27

申请号：US09655710

申请日：2000-09-05

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq Ur Rahman

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq Ur Rahman

IPC分类号： A61K36/484 ,  A61K45/06 ,  A61K35/78

CPC分类号： A61K45/06 ,  A61K36/484 ,  A61K2300/00

摘要： The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

摘要翻译： 本发明涉及作为植物来源的糖苷“甘草甜素”的非生物碱化合物作为抗生素和其它药物（包括抗感染和抗癌剂）的活性和可获得性的高效生物增强剂的新用途。 本发明的分子有助于植物和动物细胞以及革兰氏阳性和革兰氏阴性菌在细胞膜上吸收/吸收抗生素和其他分子，因此可用作促进剂或生物增殖剂分子以增加感染性 的药物和营养药物。 本身没有抗微生物或细胞毒活性的化合物是减少药物用量以避免耐药性和抗感染和抗癌疗法中的其他副作用的安全候选物。

公开(公告)号：US20060057234A1

公开(公告)日：2006-03-16

申请号：US11269594

申请日：2005-11-09

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq-Ur Rahman

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq-Ur Rahman

IPC分类号： A61K36/484 ,  A61K31/496 ,  A61K31/4709

CPC分类号： A61K45/06 ,  A61K36/484 ,  A61K2300/00

摘要： The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

摘要翻译： 本发明涉及作为植物来源的糖苷“甘草甜素”的非生物碱化合物作为抗生素和其它药物（包括抗感染和抗癌剂）的活性和可获得性的高效生物增强剂的新用途。 本发明的分子有助于植物和动物细胞以及革兰氏阳性和革兰氏阴性菌在细胞膜上吸收/吸收抗生素和其他分子，因此可用作促进剂或生物增殖剂分子以增加感染性 的药物和营养药物。 本身没有抗微生物或细胞毒活性的化合物是减少药物用量以避免耐药性和抗感染和抗癌疗法中的其他副作用的安全候选物。

公开(公告)号：US06896907B2

公开(公告)日：2005-05-24

申请号：US10135763

申请日：2002-05-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  A61K35/24 ,  A61K35/23

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06410059B1

公开(公告)日：2002-06-25

申请号：US09726307

申请日：2000-12-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K3522

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： A pharmaceutical composition comprising an antibiotic and cow urine distillate in an amount effective to enhance antimicrobial effect of the antibiotic is disclosed. The antibiotic can be an antifungal agent. The antibiotic can be a quinolone or a fluoroquinolone. The antifungal agent can be azoles, clotrimazole, mystatin or amphotericin.

摘要翻译： 公开了一种药物组合物，其包含抗生素和牛尿液馏出物，其量有效提高抗生素的抗微生物作用。 抗生素可以是抗真菌剂。 抗生素可以是喹诺酮或氟喹诺酮类。 抗真菌剂可以是唑类，克霉唑，丝裂霉素或两性霉素。

公开(公告)号：US06514541B2

公开(公告)日：2003-02-04

申请号：US09536124

申请日：2000-03-28

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： A61K3578

CPC分类号： A61K36/23 ,  A61K36/534 ,  Y10S514/924 ,  A61K2300/00

摘要： A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.

摘要翻译： 一种可用于治疗耐药性细菌感染的制剂，其包含从植物Trachyspermum ammi获得的有效量的百里酚，含有从Mentha spicata和Mentha arvensis的杂种获得的适量的单萜和常规添加剂的薄荷油。 通过施用治疗有效量的制剂，通过混合上述成分和用于治疗患者耐药性的方法来制备制剂的方法。

公开(公告)号：US06824795B2

公开(公告)日：2004-11-30

申请号：US10322731

申请日：2002-12-19

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Ajit Kumar Shasney ,  Mahendra Pandurang Darokar ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Krishna Kumar Agarwal ,  Ateeque Ahmed ,  Nirmal Kumar Patra ,  Prachi Sinha ,  Sunita Dhawan ,  Dharmendra Saikia ,  Sushil Kumar

IPC分类号： A61K3578

CPC分类号： A61K36/23 ,  A61K36/534 ,  A61K2300/00

摘要： A formulation useful in the treatment of drug resistant bacterial infections comprising an effective amount of thymol obtained from the plant Trachyspermum ammi, mint oil containing an appropriate amount of monoterpenes obtained from a hybrid of Mentha spicata and Mentha arvensis, and conventional additives. A method for producing the formulation by mixing the above ingredients and a method for the treatment of drug resistance in a patient by administration of a therapeutically effective amount of the formulation.

摘要翻译： 一种可用于治疗耐药性细菌感染的制剂，其包含从植物Trachyspermum ammi获得的有效量的百里酚，含有从Mentha spicata和Mentha arvensis的杂种获得的适量的单萜和常规添加剂的薄荷油。 通过施用治疗有效量的制剂，通过混合上述成分和用于治疗患者耐药性的方法来制备制剂的方法。

公开(公告)号：USPP13110P2

公开(公告)日：2002-10-22

申请号：US09538341

申请日：2000-03-29

申请人： Sushil Kumar ,  Janak Raj Bahl ,  Ravi Prakash Bansal ,  Shri Niwas Garg ,  Arif Ali Naqvi ,  Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Vikram Singh ,  Sweta Sinha

发明人： Sushil Kumar ,  Janak Raj Bahl ,  Ravi Prakash Bansal ,  Shri Niwas Garg ,  Arif Ali Naqvi ,  Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Vikram Singh ,  Sweta Sinha

IPC分类号： A01H500

CPC分类号： A01H5/02

摘要： A new and distinct mutant plant of Lippia alba called ‘Bhurakshak,’ characterized by novel aroma of the oil constituting 7.2% 1, 8 cineole, 42.3% linalool, 12.9% citral (b) and 14.2% citral (a) as a major terpenoids, and having a unique RAPD profile as shown in FIG. 1 of the drawings.

摘要翻译： 一种新的和不同的Lippia alba的突变植物称为“Bhurakshak”，其特征在于油的新颖香气构成主要萜类化合物的7.2％1,8Cineole，42.3％芳樟醇，12.9％柠檬醛（b）和14.2％柠檬醛（a） 并且具有如图1所示的唯一RAPD轮廓。