公开(公告)号：US20170281907A1

公开(公告)日：2017-10-05

申请号：US15467554

申请日：2017-03-23

Applicant: Surmodics, Inc.

Inventor： Bruce M. Jelle ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Nathan A. Lockwood

IPC: A61M25/06 ,  A61M25/00

Abstract: Embodiments herein include an insertion tool for inserting a medical device into another medical device, such as a hemostasis sealing valve, and related methods. In an embodiment, an insertion tool includes a guide sheath and a protection tube. The guide sheath can include a flared proximal end. The guide sheath can further include a central lumen. The guide sheath can further include a locking notch disposed on the inner surface between the proximal end and the distal end. The protection tube can include a flared proximal end. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube can be sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

公开(公告)号：US09555119B2

公开(公告)日：2017-01-31

申请号：US14072520

申请日：2013-11-05

Applicant: SurModics, Inc.

Inventor： Joseph Ventura ,  Shannon Wadman ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

IPC: A61K31/337 ,  A61K47/34 ,  A61L27/18 ,  A61L27/54 ,  A61K9/00

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在更具体的实施方案中，阳离子递送剂包括支链PEI。 还公开了制备递送组合物的方法，以及试剂盒和使用方法。

公开(公告)号：US20160089480A1

公开(公告)日：2016-03-31

申请号：US14860128

申请日：2015-09-21

Applicant: SurModics, Inc.

Inventor： Ralph A. Chappa ,  Nathan A. Lockwood ,  Joseph Schmidt McGonigle

IPC: A61L29/14 ,  A61L29/04 ,  C08J3/20 ,  A61L29/08

CPC classification number: A61L29/14 ,  A61L29/049 ,  A61L29/085 ,  A61L31/041 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/06 ,  C08J3/203 ,  C08J2375/04 ,  C08J2429/10 ,  C08J2437/00 ,  C08L73/02 ,  C08L75/04

Abstract: Embodiments of the invention include medical device elements formed from polymers with lubricious properties. In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括由具有光滑性质的聚合物形成的医疗装置元件。 在一个实施例中，包括形成医疗装置元件的方法。 该方法可以包括混合第一聚合物组分和第二聚合物组分以形成聚合物混合物。 该方法还可以包括将聚合物混合物形成到医疗装置元件中。 该方法还可以包括用酸或碱中的至少一种处理聚合物混合物。 在一个实施例中，包括医疗装置。 医疗装置可以包括润滑元件，润滑元件包括第一聚合物组分和第二聚合物组分的混合物。 第二聚合物组分可以包括在形成元素之后用至少一种酸或碱处理的聚合物。 本文还包括其它实施例。