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    Two-part insertion tool and methods
    2.
    发明授权
    Two-part insertion tool and methods 有权

    公开(公告)号：US10806904B2

    公开(公告)日：2020-10-20

    申请号：US15467554

    申请日：2017-03-23

    申请人： Surmodics, Inc.

    发明人： Bruce M. Jelle ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Nathan A. Lockwood

    IPC分类号： A61M25/06 ,  A61M25/00 ,  A61M39/06

    摘要： Embodiments herein include an insertion tool for inserting a medical device into another medical device, such as a hemostasis sealing valve, and related methods. In an embodiment, an insertion tool includes a guide sheath and a protection tube. The guide sheath can include a flared proximal end. The guide sheath can further include a central lumen. The guide sheath can further include a locking notch disposed on the inner surface between the proximal end and the distal end. The protection tube can include a flared proximal end. A portion of the protection tube can be situated within the central lumen of the guide sheath. The flared proximal end of the protection tube can be sized to fit within the locking notch and can have an outer diameter larger than portions of the inner surface immediately adjacent to the locking notch. Other embodiments are also included herein.

    Lubricious medical device elements
    3.
    发明授权
    Lubricious medical device elements 有权

    公开(公告)号：US10124088B2

    公开(公告)日：2018-11-13

    申请号：US14860128

    申请日：2015-09-21

    申请人： SurModics, Inc.

    发明人： Ralph A. Chappa ,  Nathan A. Lockwood ,  Joseph Schmidt McGonigle

    IPC分类号： A61L29/14 ,  A61L29/08 ,  A61L29/04 ,  C08J3/20 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14

    摘要： Embodiments of the invention include medical device elements formed from polymers with lubricious properties. In an embodiment, a method of forming a medical device element is included. The method can include mixing a first polymeric component and a second polymeric component to form a polymer mixture. The method can further include forming the polymer mixture into the medical device element. The method can also include treating the polymer mixture with at least one of an acid or a base. In an embodiment, a medical device is included. The medical device can include a lubricious element, the lubricious element comprising a mixture of a first polymeric component and a second polymeric component. The second polymeric component can include a polymer that is treated with at least one of an acid or a base after formation of the element. Other embodiments are also included herein.

    COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS
    6.
    发明申请
    COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS 有权
    用于输送疏水活性剂的组合物和方法

    公开(公告)号：US20170072057A1

    公开(公告)日：2017-03-16

    申请号：US15357496

    申请日：2016-11-21

    申请人： Surmodics, Inc.

    发明人： Joseph Ventura ,  Shannon Wadman ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

    IPC分类号： A61K47/34 ,  A61K9/08 ,  A61K31/337

    CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

    摘要： Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

    摘要翻译： 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在更具体的实施方案中，阳离子递送剂包括支链PEI。 还公开了制备递送组合物的方法，以及试剂盒和使用方法。

    COMPOSITIONS AND METHODS FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS
    8.
    发明申请
    COMPOSITIONS AND METHODS FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS 审中-公开
    用于输送疏水活性剂的组合物和方法

    公开(公告)号：US20140336571A1

    公开(公告)日：2014-11-13

    申请号：US14280170

    申请日：2014-05-16

    申请人： SurModics, Inc.

    发明人： Joram Slager ,  Dale G. Swan ,  Darin DuMez ,  Joseph Ventura ,  Shannon Wadman ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

    IPC分类号： A61K47/32 ,  A61K31/436 ,  A61L29/04 ,  A61M25/10 ,  A61L29/08 ,  A61L29/16 ,  A61K31/337 ,  A61K9/14

    CPC分类号： A61L29/041 ,  A61K9/0019 ,  A61K31/337 ,  A61K31/436 ,  A61K47/34 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/62 ,  A61L2300/63 ,  A61L2400/06 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  C08L79/02

    摘要： Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.

    摘要翻译： 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在一个实施方案中，本发明包括药物递送装置，其包括基底; 以及设置在基材上的被覆治疗剂颗粒，所述涂敷的治疗剂颗粒包含颗粒状疏水性治疗剂; 和乙烯基胺聚合物。 制备递送组合物的方法以及试剂盒和使用方法也包括在本文中。

    COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS
    9.
    发明申请
    COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS 有权
    用于输送疏水活性剂的组合物和方法

    公开(公告)号：US20140142166A1

    公开(公告)日：2014-05-22

    申请号：US14072520

    申请日：2013-11-05

    申请人： SurModics, Inc.

    发明人： Joseph Ventura ,  Shannon Wadman ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

    IPC分类号： A61K47/34 ,  A61K31/337

    CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

    摘要： Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

    摘要翻译： 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在更具体的实施方案中，阳离子递送剂包括支链PEI。 还公开了制备递送组合物的方法，以及试剂盒和使用方法。