公开(公告)号：US20170112973A1

公开(公告)日：2017-04-27

申请号：US15385112

申请日：2016-12-20

Applicant: Surmodics, Inc.

Inventor： Joram Slager ,  Toni M. Heyer ,  David E. Babcock

IPC: A61L29/16 ,  C12N15/113 ,  A61M25/10 ,  A61K31/713 ,  A61K47/34 ,  A61L29/08 ,  A61K31/337

CPC classification number: A61L29/085 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/713 ,  A61K47/34 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/62 ,  A61L2300/802 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C08L39/06 ,  C08L33/26

Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

公开(公告)号：US20150140107A1

公开(公告)日：2015-05-21

申请号：US14609270

申请日：2015-01-29

Applicant: SurModics, Inc.

Inventor： Joram Slager ,  Toni M. Heyer ,  David E. Babcock

IPC: A61L29/08 ,  A61L29/16

CPC classification number: A61L29/085 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/713 ,  A61K47/34 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/62 ,  A61L2300/802 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C08L39/06 ,  C08L33/26

Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括药物递送涂层和包括其的装置。 在一个实施方案中，本发明包括包含聚合物层的药物递送涂层。 聚合物层可包括亲水性外表面。 涂层还可以包括接触亲水性外表面的基体。 基质可以包括颗粒疏水性治疗剂和阳离子剂。 聚合物层还可以包括具有侧基光反应性基团的亲水聚合物和包含两个芳基酮官能团的光交联剂。 本文还包括其它实施例。