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    ARTICLE COATINGS INCLUDING OLIGOMERIZED POLYPHENOL LAYER AND BIOLOGICAL METHODS OF USE
    5.
    发明申请
    ARTICLE COATINGS INCLUDING OLIGOMERIZED POLYPHENOL LAYER AND BIOLOGICAL METHODS OF USE 审中-公开

    公开(公告)号：US20190275209A1

    公开(公告)日：2019-09-12

    申请号：US16272808

    申请日：2019-02-11

    Applicant: Surmodics, Inc.

    Inventor： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

    IPC: A61L29/08 ,  A61L27/34 ,  A61L29/06 ,  A61K31/7024 ,  G01N33/543 ,  A61L29/16

    Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

    LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES
    6.
    发明申请
    LUBRICIOUS MEDICAL DEVICE COATING WITH LOW PARTICULATES 审中-公开

    公开(公告)号：US20170304506A1

    公开(公告)日：2017-10-26

    申请号：US15643564

    申请日：2017-07-07

    Applicant: Surmodics, Inc.

    Inventor： David E. Babcock

    IPC: A61L29/08 ,  A61L31/10 ,  A61L27/34 ,  A61L29/14

    Abstract: Embodiments of the invention include lubricious medical device coatings. In an embodiment the invention includes a coating for a medical device including a first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; and a first cross-linking agent comprising at least two photoreactive groups; a second layer disposed on the first layer comprising polyvinylpyrrolidone derivatized with a photoreactive group; a second cross-linking agent comprising at least two photoreactive groups; and a polymer comprising polyacrylamide, the polymer derivatized with at least one photoreactive group. Other embodiments are included herein.

    Lubricious coatings with surface salt groups
    9.
    发明授权
    Lubricious coatings with surface salt groups 有权

    公开(公告)号：US10342898B2

    公开(公告)日：2019-07-09

    申请号：US15375442

    申请日：2016-12-12

    Applicant: Surmodics, Inc.

    Inventor： David E. Babcock ,  Joram Slager ,  Robert W. Hergenrother

    IPC: B05D7/02 ,  B05D5/08 ,  B05D1/18 ,  A61L29/14 ,  A61L29/08 ,  B05D3/00 ,  B05D3/06 ,  B05D7/00

    Abstract: Embodiments herein include coated medical devices and coatings with salt groups. In an embodiment, a coated medical device is included, the coated medical device including a substrate and a polymeric layer disposed over the substrate. The polymeric layer includes a polymer and has an exterior surface. The coated medical device further includes a plurality of salt groups bonded to the polymer of the polymeric layer and disposed on the exterior surface of the polymeric layer. The salt groups can be the reaction product of a reactive group with an acid or base. In an embodiment, a method of making a medical device is included. Other embodiments are also included herein.

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