公开(公告)号：US20070199891A1

公开(公告)日：2007-08-30

申请号：US10599128

申请日：2005-03-18

申请人： Kimihiro Mabuchi ,  Hideyuki Yokota ,  Katsuaki Kuze ,  Noriyuki Tamamura ,  Makoto Ono ,  Noriko Monden ,  Noriaki Kato ,  Hiroshi Shibano ,  Katsuhiko Nose

发明人： Kimihiro Mabuchi ,  Hideyuki Yokota ,  Katsuaki Kuze ,  Noriyuki Tamamura ,  Makoto Ono ,  Noriko Monden ,  Noriaki Kato ,  Hiroshi Shibano ,  Katsuhiko Nose

IPC分类号： B01D69/00 ,  B01D71/28

CPC分类号： B01D69/08 ,  B01D67/0011 ,  B01D67/0013 ,  B01D69/085 ,  B01D69/087 ,  B01D71/68 ,  B01D2323/02 ,  B01D2323/12 ,  B01D2325/20 ,  B01D2325/28 ,  D01D5/24 ,  D01F6/94

摘要： The present invention relates to a permselective separation membrane that can be used in blood purifying treatment. More particularly, the present invention relates to a polysulfone-based permselective separation membrane which has well-balanced separation properties, highly stable safety and performance, and also can be smoothly assembled into a module, and a method for producing the same.

摘要翻译： 本发明涉及可用于血液净化处理的选择性选择性分离膜。 更具体地说，本发明涉及具有良好平衡的分离性能，高度稳定的安全性和性能的聚砜类选择性分离膜，并且也可以顺利地组装到模块中，及其制造方法。

公开(公告)号：US09492794B2

公开(公告)日：2016-11-15

申请号：US13578416

申请日：2011-03-08

申请人： Hideyuki Yokota ,  Toru Uenishi ,  Hirofumi Ogawa ,  Satoru Ashitaka ,  Noriko Monden

发明人： Hideyuki Yokota ,  Toru Uenishi ,  Hirofumi Ogawa ,  Satoru Ashitaka ,  Noriko Monden

IPC分类号： B01D69/02 ,  B01D69/08 ,  B01D71/44 ,  B01D71/68

CPC分类号： B01D69/02 ,  B01D69/08 ,  B01D69/087 ,  B01D71/44 ,  B01D71/68 ,  B01D2325/026 ,  B01D2325/20 ,  B01D2325/28 ,  B01D2325/36

摘要： An object of the present invention is to provide a porous hollow fiber membrane for the treatment of a protein-containing liquid where the substances to be removed such as small-sized virus contained in a solution can be efficiently separated and removed and, at the same time, useful substances to be recovered such as protein can be efficiently permeated and the decrease in the permeation characteristics thereof with elapse of time is small. The porous hollow fiber membrane for the treatment of a protein-containing liquid of the present invention is characterized in that the membrane comprises a hydrophobic polymer and a hydrophilic polymer, its permeability for pure water is 10 to 300 L/(h·m2·bar) and, when a 0.5% immunoglobulin solution is subjected to filtration at a constant pressure of 1.0 bar for 60 minutes in dead-end filtration mode, its filtration time and accumulated amount of recovered filtrate are substantially in a linear relation.

摘要翻译： 本发明的目的是提供一种用于处理含蛋白质液体的多孔中空纤维膜，其中可以有效地分离和除去溶液中所含的小尺寸病毒等待除去的物质，同时 可以有效地渗透有效回收的物质如蛋白质，并且随着时间的流逝，其渗透特性的降低也很小。 用于处理本发明的含蛋白质的液体的多孔中空纤维膜的特征在于，所述膜包含疏水性聚合物和亲水性聚合物，其纯水的渗透性为10〜300L /（h·m········· ），并且当在死端过滤模式中将0.5％免疫球蛋白溶液在1.0巴的恒定压力下过滤60分钟时，其过滤时间和回收滤液的累积量基本上呈线性关系。

公开(公告)号：US5541305A

公开(公告)日：1996-07-30

申请号：US412513

申请日：1995-03-29

申请人： Hideyuki Yokota ,  Masakazu Tanaka

发明人： Hideyuki Yokota ,  Masakazu Tanaka

IPC分类号： A61L33/00 ,  A61K31/725 ,  C08B37/10

CPC分类号： A61L33/0023

摘要： A material compatible with blood obtained by heparinizing a polymer having quarternary ammonium groups with an alkali metal salt or an alkaline earth metal salt of heparin or the analog by ion exchange is provided. The equivalent ratio (M/S) of alkali metal atoms or alkaline earth metal atoms (M) in the heparin or the analog bonded to the polymer to sulfur atoms (S) in heparin or the analog bonded to the polymer is 0.4 or less.

摘要翻译： 提供了与通过用碱金属盐或肝素的碱土金属盐或通过离子交换的类似物将具有季铵基的聚合物肝素化获得的血液相容的材料。 肝素中的碱金属原子或碱土金属原子（M）或与聚合物中与硫原子（S）键合的类似物的等价比（M / S）为0.4以下。

公开(公告)号：US09795932B2

公开(公告)日：2017-10-24

申请号：US13142125

申请日：2009-12-24

申请人： Hideyuki Yokota ,  Noriaki Kato ,  Hirofumi Ogawa ,  Junsuke Morita

发明人： Hideyuki Yokota ,  Noriaki Kato ,  Hirofumi Ogawa ,  Junsuke Morita

IPC分类号： B01D69/08 ,  B01D71/68 ,  B01D69/02

CPC分类号： B01D71/68 ,  B01D69/02 ,  B01D69/08 ,  B01D69/081 ,  B01D69/087 ,  B01D2239/1233 ,  B01D2239/1258 ,  B01D2325/02 ,  B01D2325/021 ,  B01D2325/022 ,  B01D2325/023 ,  B01D2325/20

摘要： The purpose of the present invention is to provide a porous hollow fiber membrane that can efficiently separate and remove the substances to be removed such as small-particle virus contained in a solution and, at the same time, useful recovering substances such as protein can be efficiently permeated and the decrease of its transmission rate with elapse of time is small. The porous hollow fiber membrane of the present invention is characterized in that the filtration downstream surface thereof has dot-shaped or slit-shaped pores, the filtration upstream surface thereof is a network structure or a fine particle aggregate structure, the central region of the membrane is composed of a substantially homogeneous structure, the membrane wall is composed of a structure having substantially no macrovoids, the permeability for pure water is 10 to 300 L/(h·m2·bar) and the permeability for a 0.1% by weight solution of bovine γ-globulin is 30 to 100% of the permeability for pure water. Also, the hollow fiber membrane is characterized in that the permeability for a 0.1% by weight solution of bovine γ-globulin in a 20 mmol/L phosphate buffer is 30 to 100% of the permeability for a 0.1% by weight solution of bovine γ-globulin in a 20 mmol/L phosphate-buffered physiological saline solution.

公开(公告)号：US08881915B2

公开(公告)日：2014-11-11

申请号：US12298456

申请日：2007-04-25

申请人： Hideyuki Yokota ,  Noriaki Kato ,  Hirofumi Ogawa ,  Junsuke Morita

发明人： Hideyuki Yokota ,  Noriaki Kato ,  Hirofumi Ogawa ,  Junsuke Morita

IPC分类号： B01D39/16 ,  B01D63/02 ,  B01D63/06 ,  B01D69/08 ,  D01F1/08 ,  B32B3/12 ,  B01D71/68 ,  B01D71/44 ,  B01D69/02

CPC分类号： B01D69/087 ,  B01D69/02 ,  B01D69/08 ,  B01D71/44 ,  B01D71/68 ,  B01D2325/022 ,  B01D2325/36 ,  B01D2325/38 ,  Y10T428/249921 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/24998 ,  Y10T428/2975

摘要： PURPOSE: To provide a polymeric porous hollow fiber membrane which exhibits excellent fractionation performance and excellent permeability in treatment of a variety of aqueous fluids and also shows sufficient strength when incorporated into a module or used to treat a fluid, and which is excellent in aging stability in these performances and characteristics and is also excellent in membrane performance recoverability by washing, and which is especially suitable for treatment of a polyphenol-containing beverage and is expected to effectively harmonize the flavor of such a beverage.SOLUTION: A polymeric porous hollow fiber membrane of the present invention is characterized in that (a) the hollow fiber membrane has skin layers on its inner and outer surfaces; (b) the diameters of the pores in the inner surface are smaller than the diameters of the pores in the outer surface; (c) the porosity tends to increase from the inner surface toward the outer surface, and then tends to decrease from at least one portion having a maximum porosity, of the wall section of the membrane, toward the outer surface; and (d) the hollow fiber membrane satisfies a relationship of 2 [%]≦DR≦20 [%], wherein the critical diameter of a fine particle to be removed, found by a fine particle-passing test, is φmax [μm]; the diameter of the pores in the inner surface is dIS [μm]; and the proportion of the pores with dIS exceeding φmax is DR [%]. This polymeric porous hollow fiber membrane is also characterized in that the adsorption of polyphenol per a surface area of 1 m2 defined by the inner and outer surfaces of the membrane is from 50 to 500 mg.

摘要翻译： 目的：提供一种聚合多孔中空纤维膜，其在各种水性流体的处理中表现出优异的分级性能和优异的渗透性，并且当结合到模块中或用于处理流体时也显示出足够的强度，并且其老化稳定性优异 在这些性能和特性中，通过洗涤也具有优异的膜性能可回收性，并且其特别适用于处理含多酚饮料，并且预期能有效地协调这种饮料的风味。 解决方案：本发明的聚合物多孔中空纤维膜的特征在于：（a）中空纤维膜在其内表面和外表面上具有表皮层; （b）内表面的孔的直径小于外表面的孔的直径; （c）孔隙率从内表面朝向外表面增加，然后趋向于从膜的壁部的最大孔隙率的至少一部分朝向外表面减小; 和（d）中空纤维膜满足2 [％]＆nlE; DR＆nlE; 20 [％]的关系，其中通过细粒通过试验发现的要除去的微粒的临界直径为最大 [μm]; 内表面孔的直径为dIS [μm]。 dIS超过最大孔的比例为DR [％]。 该聚合物多孔中空纤维膜的特征还在于，由膜的内表面和外表面限定的1m 2表面积的多酚的吸附量为50〜500mg。

公开(公告)号：US20110259816A1

公开(公告)日：2011-10-27

申请号：US13142125

申请日：2009-12-24

申请人： Hideyuki Yokota ,  Noriaki Kato ,  Hirofumi Ogawa ,  Junsuke Morita

发明人： Hideyuki Yokota ,  Noriaki Kato ,  Hirofumi Ogawa ,  Junsuke Morita

IPC分类号： B01D69/08

CPC分类号： B01D71/68 ,  B01D69/02 ,  B01D69/08 ,  B01D69/081 ,  B01D69/087 ,  B01D2239/1233 ,  B01D2239/1258 ,  B01D2325/02 ,  B01D2325/021 ,  B01D2325/022 ,  B01D2325/023 ,  B01D2325/20

摘要： The purpose of the present invention is to provide a porous hollow fiber membrane that can efficiently separate and remove the substances to be removed such as small-particle virus contained in a solution and, at the same time, useful recovering substances such as protein can be efficiently permeated and the decrease of its transmission rate with elapse of time is small. The porous hollow fiber membrane of the present invention is characterized in that the filtration downstream surface thereof has dot-shaped or slit-shaped pores, the filtration upstream surface thereof is a network structure or a fine particle aggregate structure, the central region of the membrane is composed of a substantially homogeneous structure, the membrane wall is composed of a structure having substantially no macrovoids, the permeability for pure water is 10 to 300 L/(h·m2·bar) and the permeability for a 0.1% by weight solution of bovine γ-globulin is 30 to 100% of the permeability for pure water. Also, the hollow fiber membrane is characterized in that the permeability for a 0.1% by weight solution of bovine γ-globulin in a 20 mmol/L phosphate buffer is 30 to 100% of the permeability for a 0.1% by weight solution of bovine γ-globulin in a 20 mmol/L phosphate-buffered physiological saline solution.

摘要翻译： 本发明的目的是提供一种多孔中空纤维膜，其能够有效地分离除去溶解物中所含的小粒子病毒等被除去物质，并且同时可用于回收物质如蛋白质可以是 有效渗透，随着时间的流逝，传播速率的下降也很小。 本发明的多孔中空纤维膜的特征在于，其过滤下游表面具有点状或狭缝状的孔，其过滤上游面为网状结构或细颗粒聚集体结构，膜的中心区域 由基本上均匀的结构构成，膜壁由基本上没有大孔的结构构成，纯水的渗透性为10〜300L /（h·m 2·bar），并且0.1重量％的 牛γ-球蛋白是纯水的渗透性的30〜100％。 此外，中空纤维膜的特征在于，0.1％重量的牛γ-球蛋白溶液在20mmol / L磷酸盐缓冲液中的渗透性为0.1％（重量）牛γ溶液的渗透性的30〜100％ - 球蛋白在20 mmol / L磷酸盐缓冲生理盐水溶液中。

公开(公告)号：US08225941B2

公开(公告)日：2012-07-24

申请号：US12682814

申请日：2008-10-16

申请人： Hirofumi Ogawa ,  Noriaki Kato ,  Hideyuki Yokota ,  Junsuke Morita

发明人： Hirofumi Ogawa ,  Noriaki Kato ,  Hideyuki Yokota ,  Junsuke Morita

IPC分类号： B01D33/21 ,  B01D39/00 ,  B01D39/14 ,  B01D70/28

CPC分类号： C02F1/444 ,  B01D69/02 ,  B01D69/081 ,  B01D2325/022 ,  B01D2325/04

摘要： The present invention provides a hollow fiber membrane for treating liquids. When used for a hollow fiber membrane module for refining a fermented liquid such as beer or wine, the hollow fiber membrane exhibits a high filtration performance per unit area thereof, with reduced clogging of the membrane. The membrane performance is sufficiently recovered by washing.The present invention is a hollow fiber membrane for treating liquids, wherein a ratio of Flux 120 to Flux 30 is 0.45 or higher when filtration is performed by supplying a solution having a turbidity of 20 NTU into a hollow fiber membrane having an internal diameter of 500 to 1500 μm and a membrane thickness of 100 to 500 μm with a transmembrane pressure of 1.5 bar, the Flux 30 being flux 30 minutes after the start of the filtration, the Flux 120 being flux 120 minutes after the start of the filtration.

摘要翻译： 本发明提供一种用于处理液体的中空纤维膜。 当用于中空纤维膜组件用于精炼啤酒或葡萄酒等发酵液时，中空纤维膜的单位面积显示出高的过滤性能，同时膜的堵塞减少。 通过洗涤充分回收膜性能。 本发明是用于处理液体的中空纤维膜，其中当通过将具有20NTU的浊度的溶液供应到内径为500的中空纤维膜中时，通量120与通量30的比例为0.45或更高 至1500微米，膜厚为100至500微米，跨膜压力为1.5巴，Flux 30在开始过滤后30分钟通入，Flux 120在开始过滤120分钟后通入。

公开(公告)号：US20100219122A1

公开(公告)日：2010-09-02

申请号：US12682814

申请日：2008-10-16

申请人： Hirofumi Ogawa ,  Noriaki Kato ,  Hideyuki Yokota ,  Junsuke Morita

发明人： Hirofumi Ogawa ,  Noriaki Kato ,  Hideyuki Yokota ,  Junsuke Morita

IPC分类号： B01D69/08

CPC分类号： C02F1/444 ,  B01D69/02 ,  B01D69/081 ,  B01D2325/022 ,  B01D2325/04

摘要： The present invention provides a hollow fiber membrane for treating liquids. When used for a hollow fiber membrane module for refining a fermented liquid such as beer or wine, the hollow fiber membrane exhibits a high filtration performance per unit area thereof, with reduced clogging of the membrane. The membrane performance is sufficiently recovered by washing.The present invention is a hollow fiber membrane for treating liquids, wherein a ratio of Flux 120 to Flux 30 is 0.45 or higher when filtration is performed by supplying a solution having a turbidity of 20 NTU into a hollow fiber membrane having an internal diameter of 500 to 1500 μm and a membrane thickness of 100 to 500 μm with a transmembrane pressure of 1.5 bar, the Flux 30 being flux 30 minutes after the start of the filtration, the Flux 120 being flux 120 minutes after the start of the filtration.

摘要翻译： 本发明提供一种用于处理液体的中空纤维膜。 当用于中空纤维膜组件用于精炼啤酒或葡萄酒等发酵液时，中空纤维膜的单位面积显示出高的过滤性能，同时膜的堵塞减少。 通过洗涤充分回收膜性能。 本发明是用于处理液体的中空纤维膜，其中当通过将具有20NTU的浊度的溶液供应到内径为500的中空纤维膜中时，通量120与通量30的比例为0.45或更高 至1500微米，膜厚为100至500微米，跨膜压力为1.5巴，Flux 30在开始过滤后30分钟通入，Flux 120在开始过滤120分钟后通入。

公开(公告)号：US20090110900A1

公开(公告)日：2009-04-30

申请号：US12298456

申请日：2007-04-25

申请人： Hideyuki Yokota ,  Noriaki Kato ,  Hirofumi Ogawa ,  Junsuke Morita

发明人： Hideyuki Yokota ,  Noriaki Kato ,  Hirofumi Ogawa ,  Junsuke Morita

IPC分类号： B32B3/26 ,  B32B5/24

CPC分类号： B01D69/087 ,  B01D69/02 ,  B01D69/08 ,  B01D71/44 ,  B01D71/68 ,  B01D2325/022 ,  B01D2325/36 ,  B01D2325/38 ,  Y10T428/249921 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/24998 ,  Y10T428/2975

摘要： Purpose: To provide a polymeric porous hollow fiber membrane which exhibits excellent fractionation performance and excellent permeability in treatment of a variety of aqueous fluids and also shows sufficient strength when incorporated into a module or used to treat a fluid, and which is excellent in aging stability in these performances and characteristics and is also excellent in membrane performance recoverability by washing, and which is especially suitable for treatment of a polyphenol-containing beverage and is expected to effectively harmonize the flavor of such a beverage. Solution: A polymeric porous hollow fiber membrane of the present invention is characterized in that (a) the hollow fiber membrane has skin layers on its inner and outer surfaces; (b) the diameters of the pores in the inner surface are smaller than the diameters of the pores in the outer surface; (c) the porosity tends to increase from the inner surface toward the outer surface, and then tends to decrease from at least one portion having a maximum porosity, of the wall section of the membrane, toward the outer surface; and (d) the hollow fiber membrane satisfies a relationship of 2 [%]≦DR≦20 [%], wherein the critical diameter of a fine particle to be removed, found by a fine particle-passing test, is φmax [μm]; the diameter of the pores in the inner surface is dIS [μm]; and the proportion of the pores with dIS exceeding φmax is DR [%] This polymeric porous hollow fiber membrane is also characterized in that the adsorption of polyphenol per a surface area of 1 m2 defined by the inner and outer surfaces of the membrane is from 50 to 500 mg.

摘要翻译： 目的：提供一种聚合多孔中空纤维膜，其在各种水性流体的处理中表现出优异的分级性能和优异的渗透性，并且当结合到模块中或用于处理流体时也显示出足够的强度，并且其老化稳定性优异 在这些性能和特性中，通过洗涤也具有优异的膜性能可回收性，并且其特别适用于处理含多酚饮料，并且预期能有效地协调这种饮料的风味。 解决方案：本发明的聚合物多孔中空纤维膜的特征在于，（a）中空纤维膜在其内表面和外表面上具有表皮层; （b）内表面的孔的直径小于外表面的孔的直径; （c）孔隙率从内表面朝向外表面增加，然后趋向于从膜的壁部的最大孔隙率的至少一部分朝向外表面减小; 和（d）中空纤维膜满足2 [％] <= DR <= 20 [％]的关系，其中通过微粒通过试验发现的要除去的微粒的临界直径为p​​himax [ 妈妈] 内表面的孔的直径为dIS [mum]; 并且dIS超过phimax的孔的比例为DR [％]。该聚合物多孔中空纤维膜的特征还在于，由膜的内表面和外表面限定的表面积为1m 2的多酚的吸附量为50 至500mg。