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19 条记录 (耗时 0.041 秒)

    BLOOD PURIFIER
    4.
    发明申请
    BLOOD PURIFIER 审中-公开
    血液净化器

    公开(公告)号：US20090272686A1

    公开(公告)日：2009-11-05

    申请号：US11910627

    申请日：2006-04-03

    申请人： Kimihiro Mabuchi ,  Hideyuki Yokota ,  Katsuaki Kuze ,  Noriko Monden ,  Noriaki Kato ,  Makoto Ohno ,  Mitsuru Suzuki

    发明人： Kimihiro Mabuchi ,  Hideyuki Yokota ,  Katsuaki Kuze ,  Noriko Monden ,  Noriaki Kato ,  Makoto Ohno ,  Mitsuru Suzuki

    IPC分类号： B01D69/08

    CPC分类号： B01D69/02 ,  A61M1/16 ,  A61M2209/06 ,  B01D67/0011 ,  B01D67/009 ,  B01D69/08 ,  B01D71/44 ,  B01D71/68 ,  B01D2325/20 ,  B01D2325/28 ,  C02F1/44 ,  C02F2103/026

    摘要： [Purpose] To provide a blood purifier which has high levels of blood compatibility, performance-retaining property when in contact with blood, and safety, and which shows an excellent water permeability-exhibiting rate after a priming treatment and has high reliability in long-term storage.[Solution] A blood purifier assembled using a polyvinyl pyrrolidone-containing polysulfone-based permselective hollow fiber membrane bundle, characterized in that the amount of polyvinyl pyrrolidone which elutes from the hollow fiber membrane bundle is 10 ppm or less, the amounts of hydrogen peroxide which elute from extracts from all the sites of the hollow fiber membrane bundle are 5 ppm or less, when the hollow fiber membrane bundle is divided into 10 portions in the lengthwise direction to test the sites of all the 10 portions according to the method regulated in the Approval Standard for Dialysis-Type Artificial Kidney Apparatus, and the water permeability of the blood purifier found at a point of time when 10 minutes has passed since the priming treatment of the blood purifier is 90% or more of the water permeability of the same found at a point of time when 24 hours has passed since the priming treatment thereof.

    摘要翻译： [目的]提供一种具有高血液相容性，与血液接触时的性能保持性和安全性的血液净化器，并且在预处理后显示出优异的透水性，并且在长期使用中具有高可靠性， 长期存储。 [解决方案]使用含聚乙烯吡咯烷酮的聚砜系渗透性中空纤维膜束组装的血液净化器，其特征在于，从中空纤维膜束洗出的聚乙烯吡咯烷酮的量为10ppm以下，过氧化氢的量 从中空纤维膜束的所有位置的提取物中洗脱出的浓度为5ppm以下，将中空纤维膜束沿长度方向分割成10份，按照本发明的方法 透析型人造肾器的认可标准和自血液净化器起动处理10分钟后发现的血液净化器的透水性为同一发现的透水性的90％以上 在自启动处理24小时后的时间点。

    Biocompatible polymers
    9.
    发明授权
    Biocompatible polymers 有权
    生物相容性聚合物

    公开(公告)号：US6040415A

    公开(公告)日：2000-03-21

    申请号：US147392

    申请日：1998-12-15

    申请人： Susumu Arimori ,  Masahiro Seko ,  Masakazu Tanaka ,  Noriko Monden ,  Hideyuki Yokota

    发明人： Susumu Arimori ,  Masahiro Seko ,  Masakazu Tanaka ,  Noriko Monden ,  Hideyuki Yokota

    IPC分类号： A61L33/06 ,  C08G18/38 ,  C08G18/32 ,  A61K31/765 ,  A61K31/785 ,  A61K31/80

    CPC分类号： C08G18/3889 ,  A61L33/068

    摘要： Tpresent invention provide a biocompatible polyurethane or oplyurethane urea containing, in the side chain, phosphorylcholine structure represented by the formula (1) ##STR1## wherein R.sup.1 is C.sub.1-20 alkyl, C.sub.6-12 aryl, C.sub.7-20 aralkyl or a group of the formula:R.sup.4 -(A).sub.n -(wherein A is C.sub.2-10 oxyalkylene, and (A).sub.n may be constituted of one kind of oxyalkylene groups or of two or more kinds of oxyalkylene groups linked together in blocks or at random; n is an integer of 1 to 30; and R.sup.4 is C.sub.1-20 alkyl, C.sub.6-12 aryl or C.sub.7-20 aralkyl); and R.sup.2 and R.sup.3 each represent C.sub.1-20 alkyl, C.sub.6-12 aryl or C.sub.7-20 aralkyl and may be the same or different; and an antithrombogenic medical product prepared using the polyurethane or polyurethane urea.

    摘要翻译： PCT No.PCT / JP98 / 01702 Sec。 371 1998年12月15日第 102（e）1998年12月15日日期PCT提交1998年4月13日PCT公布。 公开号WO98 / 46659 日本特开1998年10月22日本发明提供一种生物相容性聚氨酯或聚氨酯脲，其在侧链中含有式（1）所示的磷酸胆碱结构，其中R1为C1-20烷基，C6-12芳基，C7-20芳烷基或基团 （A）n-（其中A是C2-10氧化烯，和（A）n可以由一种氧化烯基团或两种或多种氧化烯基团在块中或随机连接而构成 ; n为1〜30的整数，R4为C1-20烷基，C6-12芳基或C7-20芳烷基）; 并且R 2和R 3各自表示C 1-20烷基，C 6-12芳基或C 7-20芳烷基，并且可以相同或不同; 和使用聚氨酯或聚氨酯脲制备的抗血栓形成的医药产品。

    POROUS HOLLOW FIBER MEMBRANE FOR TREATMENT OF PROTEIN-CONTAINING LIQUID
    10.
    发明申请
    POROUS HOLLOW FIBER MEMBRANE FOR TREATMENT OF PROTEIN-CONTAINING LIQUID 有权
    用于处理含蛋白质液体的多孔中空纤维膜

    公开(公告)号：US20120305472A1

    公开(公告)日：2012-12-06

    申请号：US13578416

    申请日：2011-03-08

    申请人： Hideyuki Yokota ,  Toru Uenishi ,  Hirofumi Ogawa ,  Satoru Ashitaka ,  Noriko Monden

    发明人： Hideyuki Yokota ,  Toru Uenishi ,  Hirofumi Ogawa ,  Satoru Ashitaka ,  Noriko Monden

    IPC分类号： B01D71/68 ,  B01D63/02

    CPC分类号： B01D69/02 ,  B01D69/08 ,  B01D69/087 ,  B01D71/44 ,  B01D71/68 ,  B01D2325/026 ,  B01D2325/20 ,  B01D2325/28 ,  B01D2325/36

    摘要： An object of the present invention is to provide a porous hollow fiber membrane for the treatment of a protein-containing liquid where the substances to be removed such as small-sized virus contained in a solution can be efficiently separated and removed and, at the same time, useful substances to be recovered such as protein can be efficiently permeated and the decrease in the permeation characteristics thereof with elapse of time is small. The porous hollow fiber membrane for the treatment of a protein-containing liquid of the present invention is characterized in that the membrane comprises a hydrophobic polymer and a hydrophilic polymer, its permeability for pure water is 10 to 300 L/(h·m2·bar) and, when a 0.5% immunoglobulin solution is subjected to filtration at a constant pressure of 1.0 bar for 60 minutes in dead-end filtration mode, its filtration time and accumulated amount of recovered filtrate are substantially in a linear relation.

    摘要翻译： 本发明的目的是提供一种用于处理含蛋白质液体的多孔中空纤维膜，其中可以有效地分离和除去溶液中所含的小尺寸病毒等待除去的物质，同时 可以有效地渗透有效回收的物质如蛋白质，并且随着时间的流逝，其渗透特性的降低也很小。 用于处理本发明的含蛋白质的液体的多孔中空纤维膜的特征在于，所述膜包含疏水性聚合物和亲水性聚合物，其纯水的渗透性为10〜300L /（h·m········· ），并且当在死端过滤模式中将0.5％免疫球蛋白溶液在1.0巴的恒定压力下过滤60分钟时，其过滤时间和回收滤液的累积量基本上呈线性关系。