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公开(公告)号：US08841111B2
公开(公告)日：2014-09-23
申请号：US13846364
申请日：2013-03-18
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US08697414B2
公开(公告)日：2014-04-15
申请号：US13969174
申请日：2013-08-16
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US08697413B2
公开(公告)日：2014-04-15
申请号：US13969148
申请日：2013-08-16
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
Abstract translation: 本说明书公开了包含灭活切割位点的梭菌毒素或梭菌毒素嵌合体，编码这种毒素或嵌合体的多核苷酸分子，包含这种毒素或嵌合体的组合物，以及产生此类毒素或嵌合体的方法。
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公开(公告)号：US08685693B2
公开(公告)日：2014-04-01
申请号：US13846338
申请日：2013-03-18
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US20130345413A1
公开(公告)日：2013-12-26
申请号：US13970766
申请日：2013-08-20
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li
IPC: C12N9/52
CPC classification number: C12N9/52 , A61K38/00 , C07K14/33 , C07K2319/01 , C12N9/96
Abstract: The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an enhanced targeting domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.
Abstract translation: 该说明书公开了修饰的梭菌毒素，其包含梭菌毒素酶促结构域，梭菌毒素易位结构域，易位域和增强的靶向结构域; 编码这种经修饰的梭菌毒素的多核苷酸分子; 以及生产这种经修饰的梭菌毒素的方法。
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Patent Agency Ranking
公开(公告)号：US20130196414A1
公开(公告)日：2013-08-01
申请号：US13846338
申请日：2013-03-18
Applicant: ALLERGAN, INC.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
IPC: C12N9/52
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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17.发明申请METHODS OF TREATING UROGENITAL-NEUROLOGICAL DISORDERS USING INTERLEUKIN RETARGETED ENDOPEPIDASES 审中-公开使用INTERLEUKIN RETARGETED ENDOPEPIDAS治疗尿路神经病的方法公开(公告)号：US20130121962A1
公开(公告)日：2013-05-16
申请号：US13721621
申请日：2012-12-20
Applicant: ALLERGAN, INC.
Inventor： Joseph Francis , Dean G. Stathakis
IPC: C07K14/54 , C12N9/52 , C07K14/33 , C07K14/475 , C07K14/485
CPC classification number: C07K14/54 , A61K38/4893 , A61K47/6415 , C07K14/33 , C07K14/475 , C07K14/485 , C12N9/52
Abstract: The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such TVEMPs and compositions.
Abstract translation: 本说明书公开了TVEMP，包含这些毒素的组合物和使用这种TVEMP和组合物治疗哺乳动物的泌尿生殖神经障碍的方法。
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公开(公告)号：US10527620B2
公开(公告)日：2020-01-07
申请号：US14792795
申请日：2015-07-07
Applicant: Allergan, Inc.
Inventor： Ron S. Broide , Brian Cai , Ester Fernandez-Salas , Joseph Francis , Catherine Rheaume
IPC: G01N33/573 , C07K16/18
Abstract: Methods and compositions for detecting BoNT/A enzymatic activity in tissues or a tissue sample are described herein. The invention encompasses antibodies that bind preferentially to BoNT/A cleaved SNAP25 and is able to preferentially detect BoNT/A cleaved SNAP25, as compared to intact (non-cleaved) SNAP25, in a tissue sample.
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公开(公告)号：US20190022195A1
公开(公告)日：2019-01-24
申请号：US15953725
申请日：2018-04-16
Applicant: Allergan, Inc.
Inventor： Eric A. Forssen , Patrick M. Hughes , David C. Rupp , Terrence Hunt , Gary Shimizu , Joseph Francis , Ron S. Broide , Ester Fernandez-Salas
Abstract: Pharmaceutical formulations comprising a clostridial derivative and a permeabilizing agent for intravesical instillation are disclosed.
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公开(公告)号：US09850476B2
公开(公告)日：2017-12-26
申请号：US15082635
申请日：2016-03-28
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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