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公开(公告)号：US20220144925A1
公开(公告)日：2022-05-12
申请号：US17573096
申请日：2022-01-11
Applicant: Allergan, Inc.
Inventor： Ester Fernandez-Salas , Joanne Wang , Patton E. Garay , Lina Wong , D. Dianne Hodges , Kei Roger Aoki
IPC: C07K16/12 , G01N33/68 , G01N33/566 , C12Q1/37 , G01N33/50 , G01N33/569
Abstract: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
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公开(公告)号：US20210340229A1
公开(公告)日：2021-11-04
申请号：US17376416
申请日：2021-07-15
Applicant: Allergan, Inc.
Inventor： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Diane Hodges , Kei Roger Aoki
IPC: C07K16/12 , G01N33/569 , C12Q1/37
Abstract: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
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公开(公告)号：US20210171614A1
公开(公告)日：2021-06-10
申请号：US17124747
申请日：2020-12-17
Applicant: Allergan, Inc.
Inventor： Ester Fernandez-Salas , Joanne Wang , Patton Garay , Lina S. Wong , D. Diane Hodges , Kei Roger Aoki
IPC: C07K16/12 , G01N33/569 , C12Q1/37
Abstract: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
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公开(公告)号：US11261240B2
公开(公告)日：2022-03-01
申请号：US17124747
申请日：2020-12-17
Applicant: Allergan, Inc.
Inventor： Ester Fernandez-Salas , Joanne Wang , Patton E. Garay , Lina Wong , D. Diane Hodges , Kei Roger Aoki
IPC: C07K16/12 , G01N33/569 , C12Q1/37
Abstract: The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutralizing α-BoNT/A antibodies.
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公开(公告)号：US20180119126A1
公开(公告)日：2018-05-03
申请号：US15845572
申请日：2017-12-18
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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Patent Agency Ranking
公开(公告)号：US09474807B2
公开(公告)日：2016-10-25
申请号：US14300746
申请日：2014-06-10
Applicant: IPSEN BIOINNOVATION LTD. , Allergan Inc.
Inventor： Keith Foster , John Chaddock , Charles Penn , Kei Roger Aoki , Joseph Francis , Lance Steward
IPC: A61K47/48 , A61K38/48 , C12N15/62 , C07K14/665 , A61K38/22
CPC classification number: C12N9/6432 , A61K38/00 , A61K38/22 , A61K38/48 , A61K47/48246 , A61K47/48338 , A61K47/48361 , A61K47/64 , A61K47/65 , A61K47/67 , C07K14/665 , C07K2319/00 , C07K2319/01 , C07K2319/21 , C07K2319/55 , C12N9/96 , C12N15/62 , C12Y304/00 , C12Y304/21006
Abstract: The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a Targeting Moiety (TM), wherein the TM is an agonist of a receptor present on a nociceptive sensory afferent cell, and wherein the receptor undergoes endocytosis to be incorporated into an endosome within the nociceptive sensory afferent cell; (ii) a non-cytotoxic protease or a fragment thereof, wherein the protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of the nociceptive sensory afferent cell; and (iii) a Translocation Domain, wherein the Translocation Domain translocates the protease or protease fragment from within the endosome, across the endosomal membrane, and into the cytosol of the nociceptive sensory afferent cell wherein the Targeting Moiety is selected from the group consisting of BAM, β-endorphin, bradykinin, substance P, dynorphin and/or nociceptin.
Abstract translation: 本发明涉及用于抑制或减少伤害性感觉传入细胞中的胞外融合的非细胞毒性蛋白质缀合物。 所述蛋白质缀合物包含：（i）靶向部分（TM），其中所述TM是存在于伤害性感觉传入细胞上的受体的激动剂，并且其中所述受体经受内吞作用以掺入伤害性感觉传入细胞内的内体 ; （ii）非细胞毒性蛋白酶或其片段，其中所述蛋白酶或蛋白酶片段能够切割伤害性感觉传入细胞的胞外融合装置的蛋白质; 易位结构域，其中易位域将内体内的蛋白酶或蛋白酶片段转移穿过内体膜，并转移到伤害性感觉传入细胞的胞质溶胶中，其中靶向部分选自BAM ，β-内啡肽，缓激肽，物质P，强啡肽和/或伤害感受肽。
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公开(公告)号：US08841111B2
公开(公告)日：2014-09-23
申请号：US13846364
申请日：2013-03-18
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US08697414B2
公开(公告)日：2014-04-15
申请号：US13969174
申请日：2013-08-16
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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公开(公告)号：US08697413B2
公开(公告)日：2014-04-15
申请号：US13969148
申请日：2013-08-16
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
Abstract translation: 本说明书公开了包含灭活切割位点的梭菌毒素或梭菌毒素嵌合体，编码这种毒素或嵌合体的多核苷酸分子，包含这种毒素或嵌合体的组合物，以及产生此类毒素或嵌合体的方法。
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公开(公告)号：US08685693B2
公开(公告)日：2014-04-01
申请号：US13846338
申请日：2013-03-18
Applicant: Allergan, Inc.
Inventor： Lance E. Steward , Sanjiv Ghanshani , Ester Fernandez-Salas , Marcella A. Gilmore , Joseph Francis , Kei Roger Aoki
CPC classification number: C12N9/52 , A61K38/4893 , C07K14/33 , C12Y304/24069
Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.
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