公开(公告)号：US20150144489A1

公开(公告)日：2015-05-28

申请号：US14402717

申请日：2014-01-06

Applicant: TECAN TRADING AG

Inventor： Daniel Hoffmeyer ,  Tiffany Lay ,  Travis Lee ,  Marc N. Feiglin ,  Werner Halg ,  Anne R. Kopf-Sill

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/044 ,  B01L2300/123 ,  B01L2400/0427 ,  B81B1/00 ,  G01N27/44756

Abstract: A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

Abstract translation: 在数字微流体系统中使用的一次性盒具有具有第一疏水表面的底层，具有第二疏水表面的刚性盖板及其间的间隙。 底层是在系统的盒容纳位置的最上表面上的柔性膜，通过负压吸引并分布在最上表面上。 板的下表面和柔性底层彼此密封。 将组装的墨盒从墨盒容纳部位一体地取出，并且可能包括样品和处理流体。 该系统具有基本单元和具有单独电极的电极阵列的中心控制单元和用于控制各个电极的选择的中心控制单元和用于通过电润湿来操纵间隙内的液滴的单独电压脉冲的中心控制单元。

公开(公告)号：US20130134040A1

公开(公告)日：2013-05-30

申请号：US13737656

申请日：2013-01-09

Applicant: TECAN TRADING AG

Inventor： Travis Lee ,  Tiffany Lay ,  Bruce Richardson ,  S. Nicholas Reimitz

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/505 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/089 ,  B01L2300/123 ,  B01L2400/0427

Abstract: A disposable cartridge had body, bottom layer with first hydrophobic surface, top layer with a second hydrophobic surface, and gap between. The bottom layer is a flexible film sealingly attached at its circumference to the top layer. No spacer is between the layers. The top layer has loading sites for transferring processing liquids into the gap. In use, the bottom layer is a working film for manipulating samples in liquid droplets and is placed on an electrode array of a digital microfluidics system having base unit with cartridge accommodation site and electrode array at the site. The electrode array is supported by a bottom substrate that extends in a first plane and has individual electrodes. The system also includes a central control unit for controlling selection of the electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting.

Abstract translation: 一次性药筒具有主体，底层具有第一疏水性表面，顶层具有第二疏水性表面，并且之间具有间隙。 底层是在其周围密封地附接到顶层的柔性膜。 层之间没有间隔物。 顶层具有用于将处理液体转移到间隙中的装载位置。 在使用中，底层是用于操作液滴中的样品的工作薄膜，并且放置在具有基座单元的数字微流体系统的电极阵列上，该基座具有筒位置和位置处的电极阵列。 电极阵列由在第一平面中延伸并具有单独电极的底部基底支撑。 该系统还包括一个中央控制单元，用于控制电极的选择，并为这些电极提供单独的电压脉冲，用于通过电润湿来操纵间隙内的液滴。